Results 181 to 190 of about 63,359 (335)

Braided quantum SU(2) groups

, 2015
We construct a family of q-deformations of SU(2) for complex parameters q not equal to 0. For real q, the deformation coincides with Woronowicz' compact quantum SU_q(2) group.
Kasprzak, Paweł, Meyer, Ralf, Roy, Sutanu, Woronowicz, Stanisław Lech   +3 more
core   +1 more source

Value and Limitations of Immunohistochemistry and Gene Sequencing for Detection of theIDH1-R132HMutation in Diffuse Glioma Biopsy Specimens [PDF]

, 2011
Matthias Preusser, Adelheid Wöhrer, Susanne Stary, Romana Höftberger, Berthold Streubel, Johannes A. Hainfellner   +5 more
openalex   +1 more source

Measurable residual disease (MRD) as a surrogate end point for clinical drug approval in acute myeloid leukemia (AML): Perspectives from the MRD Partnership and Alliance in AML Clinical Treatment Consortium

Cancer, Volume 131, Issue 13, 1 July 2025.
Abstract Despite advances in acute myeloid leukemia (AML) treatment, significant unmet medical needs remain. Surrogate end points for overall survival can accelerate the approval of novel therapies. Measurable residual disease (MRD) is a promising surrogate end point candidate, providing a sensitive and quantitative assessment of disease burden ...
Michael Boyiadzis, Andrew H. Wei, Bruno Paiva, Sylvie D. Freeman, Gertjan Kaspers, Brenda Chyla, Sarah Hersey, Reshma Patel, Brian Maloney, Marie‐Helene Blanchet Zumofen, Marlies Van Hoef, Beate Wulff, Vanessa Obourn, Shalaka Patel, Daniel Lopes de Menezes, Qian Shi, Bourras‐Rezki Bengoudifa, Natalie Dimier, Thomas J. Prior, Gail J. Roboz, Thomas Prebet   +20 more
wiley   +1 more source

Valor de la expresión del ARN mensajero de la isocitrato deshidrogenasa (IDH1) como predictor de agresividad en gliomas [PDF]

, 2012
Los gliomas son el tipo más común de tumor cerebral primario. En humanos, cinco genes codifican para la isocitrato deshidrogenasa: IDH1/2/3A/3B/3G. Mutaciones somáticas puntuales en el gen IDH1 son frecuentes en gliomas, la mayoría transiciones de una ...
Brell Doval, Marta, Couce Matovelle, Marta, Guevara de Bonis, Rocio, Ibáñez Domínguez, Javier, Sampol López, M.   +4 more
core  

TP53‐Mutated Acute Myeloid Leukemia: Unanswered Questions

Hematological Oncology, Volume 43, Issue 4, July 2025.
ABSTRACT TP53‐mutated acute myeloid leukemia (AML) remains one of the most treatment‐resistant hematologic malignancies, with poor overall survival despite advancements in therapeutic strategies. The loss of functional p53 compromises DNA repair, apoptosis, and genomic stability, rendering both conventional and novel therapies largely ineffective. This
Antonella Bruzzese, Ernesto Vigna, Enrica Antonia Martino, Caterina Labanca, Giulio Caridà, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Noemi Puccio, Antonino Neri, Fortunato Morabito, Massimo Gentile   +11 more
wiley   +1 more source

2‐Hydroxyglutarate concentration in serum from patients with gliomas does not correlate with IDH1/2 mutation status or tumor size [PDF]

, 2011
David Capper, Matthias Simon, Claus‐Dieter Langhans, Jürgen G. Okun, Jörg C. Tonn, Michael Weller, Andreas von Deimling, Christian Hartmann   +7 more
openalex   +1 more source

Ivosidenib and Azacitidine in IDH1 -Mutated AML

New England Journal of Medicine, 2022
Goodman, Aaron M, Mohyuddin, Ghulam Rehman, Prasad, Vinay   +2 more
openaire   +6 more sources

Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar, Sana Khurshid Baba, Inamu Rashid Khan, Mohd Shahnawaz Khan, Fohad Mabood Husain, Saheem Ahmad, Mohammad Haris, Mayank Singh, Ammira S. Al‐Shabeeb Akil, Muzafar A. Macha, Ajaz A. Bhat   +10 more
wiley   +1 more source

The hypermethylation of the O⁶‐methylguanine‐DNA methyltransferase gene promoter in gliomas—correlation with array comparative genome hybridization results and IDH1 mutation [PDF]

, 2011
Katja Tuononen, Olli Tynninen, Virinder Kaur Sarhadi, A. Tyybäkinoja, Mikael Lindlöf, Miia Antikainen, Juha Näpänkangas, Ari Hirvonen, Hanna Mäenpää, Anders Paetau, Sakari Knuutila   +10 more
openalex   +1 more source

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.

Cancer Cell, 2010
R. Verhaak, K. Hoadley, E. Purdom, V. Wang, Y. Qi, M. Wilkerson, C. Miller, L. Ding, Todd Golub, J. Mesirov, Gabriele Alexe, M. Lawrence, Michael J. T. O’Kelly, P. Tamayo, B. Weir, S. Gabriel, W. Winckler, Supriya Gupta, L. Jakkula, H. Feiler, J. Hodgson, C. James, J. Sarkaria, C. Brennan, A. Kahn, P. Spellman, R. Wilson, T. Speed, J. Gray, M. Meyerson, G. Getz, C. Perou, D. Hayes   +32 more
semanticscholar   +1 more source