Results 11 to 20 of about 58,205 (308)
Wild-Type IDH1 and Mutant IDH1 Opposingly Regulate Podoplanin Expression in Glioma
Translational Oncology, 2020 Isocitrate dehydrogenase (IDH) mutations occur frequently in lower-grade gliomas, which result in genome-wide epigenetic alterations. The wild-type IDH1 is reported to participate in lipid biosynthesis and amino acid metabolism, but its role in ...
Chao Sun +21 more
doaj +3 more sources
IDH1: Linking Metabolism and Epigenetics [PDF]
Frontiers in Genetics, 2018 Mutations in genes encoding enzymes of the tricarboxylic acid cycle often contribute to cancer development and progression by disrupting cell metabolism and altering the epigenetic landscape. This is exemplified by the isoforms of isocitrate dehydrogenase (IDH1/2), which metabolize isocitrate to α-Ketoglutarate (α-KG).
Silvia Raineri +3 more
openaire +4 more sources
T $$ {}_{1\rho } $$ as a Biomarker for IDH1 Mutation Status in a Glioma Mouse Model. [PDF]
NMR BiomedMice bearing IDH1‐mutant and ‐wild‐type glioma underwent quantitative T1ρ$$ {T}_{1\rho } $$ imaging over the course of tumour development. It was found that while IDH1‐wild‐type tumours present similar T1ρ$$ {T}_{1\rho } $$ values as the brain, IDH1‐mutant tumours exhibit significantly higher T1ρ$$ {T}_{1\rho } $$ values compared with the brain. T1ρ$$ {
Ehler HJS +4 more
europepmc +2 more sources
Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source
Genetic alterations in gliosarcoma and giant cell glioblastoma [PDF]
, 2015 The majority of glioblastomas develop rapidly with a short clinical history (primary glioblastoma IDH wild-type), whereas secondary glioblastomas progress from diffuse astrocytoma or anaplastic astrocytoma.
ANTONELLI, MANILA +13 more
core +1 more source
Epigenetics, 2020 Mutations in the enzyme isocitrate dehydrogenase 1 (IDH1) lead to metabolic alterations and a sustained formation of 2-hydroxyglutarate (2-HG). 2-HG is an oncometabolite as it inhibits the activity of α-ketoglutarate-dependent dioxygenases such as ten ...
Christian Gerecke +4 more
doaj +1 more source
The Frequency and clinical significance of IDH1 mutations in Chinese acute myeloid leukemia patients. [PDF]
PLoS ONE, 2013 OBJECTIVE: Mutations in the gene encoding isocitrate dehydrogenease 1 (IDH1) occur in various hematopoietic tumors including acute myeloid leukemia (AML), myeloproliferative neoplasms and myelodysplastic syndromes.
Lixun Guan +6 more
doaj +1 more source
Mutant IDH1 is required for IDH1 mutated tumor cell growth
Oncotarget, 2012 Frequent somatic hotspot mutations in isocitrate dehydrogenase 1 (IDH1) have been identified in gliomas, acute myeloid leukemias, chondrosarcomas, and other cancers, providing a likely avenue for targeted cancer therapy. However, whether mutant IDH1 protein is required for maintaining IDH1 mutated tumor cell growth remains unknown.
Jin, Genglin +9 more
openaire +3 more sources
Mutation analysis of IDH1 in paired gliomas revealed IDH1 mutation was not associated with malignant progression but predicted longer survival. [PDF]
PLoS ONE, 2013 Recurrence and progression to higher grade lesions are characteristic behaviors of gliomas. Though IDH1 mutation frequently occurs and is considered as an early event in gliomagenesis, little is known about its role in the recurrence and progression of ...
Yu Yao +10 more
doaj +1 more source