Results 11 to 20 of about 35,587 (246)

IDH1 mutation promotes lung cancer cell proliferation through methylation of Fibulin-5 [PDF]

Open Biology, 2018
Mutation in isocitrate dehydrogenase (IDH) leads to an aberrant function of the enzyme, leading to the production of hydroxyglutarate, as well as changes in cellular metabolism, DNA methylation and histone modification.
Bingdi Yan, Yanbing Hu, Tiangang Ma, Yanjun Wang   +3 more
doaj   +1 more source

Identification of Mutations in IDH1/2, DNMT3A, ASXL1 Genes of Genome Epigenetic Regulation and Their Co-Occurrence with FLT3, NPM1, RUNX1 Mutations in Acute Myeloid Leukemia

Клиническая онкогематология, 2021
Aim. To identify mutations in IDH1/IDH2, DNMT3A, and ASXL1 genes responsible for genome epigenetic regulation and their co-occurrence with FLT3, NPM1, and RUNX1 mutations in newly diagnosed adult acute myeloid leukemias (AML). Materials & Methods. The
Ekaterina Vasilevna Belotserkovskaya, E. K. Zaikova, A. V. Petukhov, O. N. Demidov, K. A. Levchuk, I. G. Budaeva, D. V. Zaitsev, Yu. D. Rogovaya, A. A. Shatilova, K. V. Bogdanov, Yu. V. Mirolyubova, T. S. Nikulina, A. Yu. Zaritskey, L. L. Girshova   +13 more
doaj   +1 more source

IDH1: Linking Metabolism and Epigenetics [PDF]

Frontiers in Genetics, 2018
Mutations in genes encoding enzymes of the tricarboxylic acid cycle often contribute to cancer development and progression by disrupting cell metabolism and altering the epigenetic landscape. This is exemplified by the isoforms of isocitrate dehydrogenase (IDH1/2), which metabolize isocitrate to α-Ketoglutarate (α-KG).
Silvia Raineri, Silvia Raineri, Jane Mellor, Jane Mellor   +3 more
openaire   +4 more sources

Mutant IDH1 and thrombosis in gliomas [PDF]

Acta Neuropathologica, 2016
Mutant isocitrate dehydrogenase 1 (IDH1) is common in gliomas, and produces D-2-hydroxyglutarate (D-2-HG). The full effects of IDH1 mutations on glioma biology and tumor microenvironment are unknown. We analyzed a discovery cohort of 169 World Health Organization (WHO) grade II-IV gliomas, followed by a validation cohort of 148 cases, for IDH1 ...
Dusten Unruh, Steven R. Schwarze, Laith Khoury, Cheddhi Thomas, Meijing Wu, Li Chen, Rui Chen, Yinxing Liu, Margaret A. Schwartz, Christina Amidei, Priya Kumthekar, Carolina G. Benjamin, Kristine Song, Caleb Dawson, Joanne M. Rispoli, Girish Fatterpekar, John G. Golfinos, Douglas Kondziolka, Matthias Karajannis, Donato Pacione, David Zagzag, Thomas McIntyre, Matija Snuderl, Craig Horbinski   +23 more
openaire   +2 more sources

IDH1 and IDH2 Mutations in Gliomas [PDF]

Current Neurology and Neuroscience Reports, 2013
Mutations in isocitrate dehydrogenase (IDH) 1 and 2, originally discovered in 2008, occur in the vast majority of low-grade gliomas and secondary high-grade gliomas. These mutations, which occur early in gliomagenesis, change the function of the enzymes, causing them to produce 2-hydroxyglutarate, a possible oncometabolite, and to not produce NADPH ...
Adam L, Cohen, Sheri L, Holmen, Howard, Colman   +2 more
openaire   +2 more sources

Isocitrate dehydrogenase 1 mutation in cholangiocarcinoma impairs tumor progression by sensitizing cells to ferroptosis

Open Medicine, 2022
The present study intends to clarify the hypothesis that isocitrate dehydrogenase 1 (IDH1) mutation in cholangiocarcinoma impairs tumor progression by sensitizing cells to ferroptosis through the in vitro and in vivo experiments.
Su Li, Huang Yi, Zheng Lei, Zhu Zhifa, Wu Yue, Li Ping   +5 more
doaj   +1 more source

Retrospective and Randomized Analysis of Influence and Correlation of Clinical and Molecular Prognostic Factors in a Mono-Operative Series of 122 Patients with Glioblastoma Treated with STR or GTR

Brain Sciences, 2020
Glioblastoma is a solid, infiltrating, and the most frequent highly malignant primary brain tumor. Our aim was to find the correlation between sex, age, preoperative Karnofsky performance status (KPS), presenting with seizures, and extent of resection ...
Maurizio Salvati, Placido Bruzzaniti, Michela Relucenti, Mariagrazia Nizzola, Pietro Familiari, Marco Giugliano, Anthony Kevin Scafa, Santi Galletta, Xiaobo Li, Rui Chen, Claudio Barbaranelli, Alessandro Frati, Antonio Santoro   +12 more
doaj   +1 more source

Metabolism, Gliomas, andIDH1 [PDF]

New England Journal of Medicine, 2010
A mutation in IDH1, which encodes an isocitrate dehydrogenase, is associated with susceptibility to glioma. This mutation results in an acquired enzyme activity that points to a potential biomarker of the mutant tumor.
Smeitink, J.A.M., Smeitink, J.A.M.
openaire   +3 more sources

Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity [PDF]

Structure, 2017
Oncogenic IDH1 and IDH2 mutations contribute to cancer via production of R-2-hydroxyglutarate (2-HG). Here, we characterize two structurally distinct mutant- and isoform-selective IDH1 inhibitors that inhibit 2-HG production. Both bind to an allosteric pocket on IDH1, yet shape it differently, highlighting the plasticity of this site.
Xiaoling, Xie, Daniel, Baird, Kimberly, Bowen, Vladimir, Capka, Jinyun, Chen, Gregg, Chenail, YoungShin, Cho, Julia, Dooley, Ali, Farsidjani, Pascal, Fortin, Darcy, Kohls, Raviraj, Kulathila, Fallon, Lin, Daniel, McKay, Lindsey, Rodrigues, David, Sage, B Barry, Touré, Simon, van der Plas, Kirk, Wright, Ming, Xu, Hong, Yin, Julian, Levell, Raymond A, Pagliarini   +22 more
openaire   +2 more sources

Non-IDH1-R132H IDH1/2 mutations are associated with increased DNA methylation and improved survival in astrocytomas, compared to IDH1-R132H mutations [PDF]

Acta Neuropathologica, 2021
AbstractSomatic mutations in the isocitrate dehydrogenase genesIDH1andIDH2occur at high frequency in several tumour types. Even though these mutations are confined to distinct hotspots, we show that gliomas are the only tumour type with an exceptionally high percentage of IDH1R132Hmutations.
Tesileanu, C. Mircea S., Vallentgoed, Wies R., Sanson, Marc, Taal, Walter, Clement, Paul M., Wick, Wolfgang, Brandes, Alba Ariela, Baurain, Jean Francais, Chinot, Olivier L., Wheeler, Helen, Gill, Sanjeev, Griffin, Matthew, Rogers, Leland, Ruda, Roberta, Weller, Michael, McBain, Catherine, Reijneveld, Jaap, Enting, Roelien H., Caparrotti, Francesca, Lesimple, Thierry, Clenton, Susan, Gijtenbeek, Anja, Lim, Elizabeth, de Vos, Filip, Mulholland, Paul J., Taphoorn, Martin J.B., de Heer, Iris, Hoogstrate, Youri, de Wit, Maurice, Boggiani, Lorenzo, Venneker, Sanne, Oosting, Jan, Bovee, Judith V.MG., Erridge, Sara, Vogelbaum, Michael A., Nowak, Anna K., Mason, Warren P., Kros, Johan M., Wesseling, Pieter, Aldape, Ken, Jenkins, Robert B., Dubbink, Hendrikus J., Baumert, Brigitta, Golfinopoulos, Vassilis, Gorlia, Thierry, van den Bent, Martin, French, Pim J.   +46 more
openaire   +12 more sources