Results 201 to 210 of about 63,359 (335)

Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
Cyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Vik S. Bebarta, Anjali K. Nath
wiley   +1 more source

IDH1/2 mutations in WHO grade II astrocytomas associated with localization and seizure as the initial symptom [PDF]

, 2012
Florian Stockhammer, Martin Misch, Hans-Joachim Helms, Ulrike Lengler, Friedrich Prall, Andreas von Deimling, Christian Hartmann   +6 more
openalex   +1 more source

IDH1 p.R132H ctDNA and D-2-hydroxyglutarate as CSF biomarkers in patients with IDH-mutant gliomas

Journal of Neuro-Oncology, 2022
Y. Fujita, Luis Nunez-Rubiano, A. Dono, A. Bellman, Mauli Shah, J. C. Rodriguez, V. Putluri, A. Kamal, N. Putluri, R. Riascos, Jay-Jiguang Zhu, Y. Esquenazi, L. Ballester   +12 more
semanticscholar   +1 more source

Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives

American Journal of Hematology, Volume 100, Issue S4, Page 30-50, June 2025.
ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley   +1 more source

Faculty Opinions recommendation of Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.

, 2009
Nephi Stella
openalex   +2 more sources

Allogeneic Stem Cell Transplant for Myelofibrosis and Myelodysplastic Syndromes: A Contemporary Review

American Journal of Hematology, Volume 100, Issue S4, Page 16-29, June 2025.
ABSTRACT Allogeneic hematopoietic stem‐cell transplantation (HCT) remains the only potentially curative therapy for patients with myelodysplastic neoplasms (MDS) and myelofibrosis (MF) and is the standard care for eligible patients with higher‐risk disease. Despite significant advancements, both diseases pose unique challenges due to their clinical and
Nico Gagelmann, Nicolaus Kröger
wiley   +1 more source

MRI detection of 2-hydroxyglutarate (2HG) to diagnosis and monitor isocitrate dehydrogenase 1 ( IDH1 )-mutant gliomal tumors [PDF]

, 2012

openalex   +1 more source

Integration of Optical Genome Mapping in the Cytogenomic and Molecular Work‐Up of Hematological Malignancies: Expert Recommendations From the International Consortium for Optical Genome Mapping

American Journal of Hematology, Volume 100, Issue 6, Page 1029-1048, June 2025.
ABSTRACT The latest updates to the classification of hematolymphoid malignancies using the World Health Organization (WHO, 5th ed.) and ICC (International Consensus Classification) criteria highlight the critical need for comprehensive and precise cytogenomic data for diagnosis, prognostication, and treatment.
Rashmi Kanagal‐Shamanna, Anna Puiggros, Isabel Granada, Gordana Raca, Katrina Rack, Mar Mallo, Barbara Dewaele, Adam C. Smith, Yassmine Akkari, Brynn Levy, Robert P. Hasserjian, Adela Cisneros, Marta Salido, Guillermo Garcia‐Manero, Hui Yang, M. Anwar Iqbal, Ravindra Kolhe, Francesc Solé, Blanca Espinet   +18 more
wiley   +1 more source

Anti-Apoptotic and Anti-Oxidant Proteins in Glioblastomas: Immunohistochemical Expression of Beclin and DJ-1 and Its Correlation with Prognosis. [PDF]

, 2019
Arcidiacono Biagio, Borrelli Giorgio, Cappabianca Paolo, Del Basso De Caro Marialaura, Donato Annalidia, Donato Giuseppe, Guadagno Elia, Malara Natalia, Pignatiello Sara, Presta Ivan, Solari Domenico, Somma Teresa   +11 more
core   +1 more source

Non-invasive in vivo assessment of IDH1 mutational status in glioma [PDF]

, 2013
Myriam M. Chaumeil, Peder E. Z. Larson, Hikari A. I. Yoshihara, Olivia M. Danforth, Daniel B. Vigneron, Sarah J. Nelson, Russell O. Pieper, Joanna J. Phillips, Sabrina M. Ronen   +8 more
openalex   +1 more source