Results 41 to 50 of about 63,359 (335)

Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics

Biomolecules, 2021
Isocitrate dehydrogenase (IDH1) catalyzes the reversible NADP+-dependent oxidation of isocitrate to α-ketoglutarate (αKG). IDH1 mutations, primarily R132H, drive > 80% of low-grade gliomas and secondary glioblastomas and facilitate the NADPH-dependent ...
Joi Weeks, Alexandra I. Strom, Vinnie Widjaja, Sati Alexander, Dahra K. Pucher, Christal D. Sohl   +5 more
doaj   +1 more source

Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors

Nature Cancer, 2022
Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability due to increased free radicals and reduced energy production.
Ali Vaziri-Gohar, J. Cassel, F. S. Mohammed, Mehrdad Zarei, J. Hue, Omid Hajihassani, Hallie Graor, Y. Srikanth, S. Karim, Ata Abbas, Erin Prendergast, Vanessa Chen, Erryk S. Katayama, K. Dukleska, I. Khokhar, A. Andren, Li Zhang, Chunying Wu, B. Erokwu, C. Flask, Mahsa Zarei, Rui Wang, Luke D. Rothermel, A. Romani, Jessica Bowers, R. Getts, C. Tatsuoka, J. Morton, I. Bederman, H. Brunengraber, C. Lyssiotis, J. Salvino, J. Brody, J. Winter   +33 more
semanticscholar   +1 more source

IDH1, Histone Methylation, and So Forth [PDF]

Cancer Cell, 2016
IDH mutants cause aberrant DNA and histone methylation and contribute to hematological and neuronal malignancies. In this issue of Cancer Cell, Inoue et al. describe a potential specific effect of IDH1 mutations that reduces Atm expression via inhibition of H3K9 demethylases, which may represent a first step toward cellular transformation.
Virginie Penard-Lacronique, Olivier Bernard   +1 more
openaire   +5 more sources

Mutation analysis of IDH1 in paired gliomas revealed IDH1 mutation was not associated with malignant progression but predicted longer survival. [PDF]

PLoS ONE, 2013
Recurrence and progression to higher grade lesions are characteristic behaviors of gliomas. Though IDH1 mutation frequently occurs and is considered as an early event in gliomagenesis, little is known about its role in the recurrence and progression of ...
Yu Yao, Aden Ka-Yin Chan, Zhi Yong Qin, Ling Chao Chen, Xin Zhang, Jesse Chung-Sean Pang, Hiu Ming Li, Yin Wang, Ying Mao, Ho-Keung Ng, Liang Fu Zhou   +10 more
doaj   +1 more source

Genetic alterations in gliosarcoma and giant cell glioblastoma [PDF]

, 2015
The majority of glioblastomas develop rapidly with a short clinical history (primary glioblastoma IDH wild-type), whereas secondary glioblastomas progress from diffuse astrocytoma or anaplastic astrocytoma.
ANTONELLI, MANILA, Capper, David, GIANGASPERO, FELICE, Kleihues, Paul, Mittelbronn, Michel, Nonoguchi, Naosuke, Oh, Ji Eun, Ohgaki, Hiroko, Ohta, Takashi, Paulus, Werner, Pierscianek, Daniela, Satomi, Kaishi, Sure, Ulrich, Vital, Anne   +13 more
core   +1 more source

The first-in-human phase I study of a brain-penetrant mutant IDH1 inhibitor DS-1001 in patients with recurrent or progressive IDH1-mutant gliomas

Neuro-Oncology, 2022
Background Approximately 70% of lower-grade gliomas harbor isocitrate dehydrogenase 1 (IDH1) mutations, resulting in the accumulation of oncometabolite D-2-hydroxyglutarate (D-2-HG); this leads to epigenetic dysregulation, oncogenesis, and subsequent ...
A. Natsume, Y. Arakawa, Y. Narita, K. Sugiyama, N. Hata, Y. Muragaki, N. Shinojima, T. Kumabe, R. Saito, K. Motomura, Y. Mineharu, Y. Miyakita, F. Yamasaki, Y. Matsushita, K. Ichimura, Kazumi Ito, Masaya Tachibana, Y. Kakurai, Naoko Okamoto, T. Asahi, Soichiro Nishijima, Tomoyuki Yamaguchi, H. Tsubouchi, Hideo Nakamura, R. Nishikawa   +24 more
semanticscholar   +1 more source

IDH1 mutations in a Brazilian series of Glioblastoma [PDF]

Clinics, 2011
GBM may manifest rapidly de novo(primary GBM), or may develop slowly from grade II orgrade III astrocytomas (secondary GBM), suggesting thatthey are distinct disease entities that evolve throughdifferent genetic pathways.In recent genome-wide analyses, high rates of sponta-neous mutations in the gene encoding cytosolic NADP-dependent isocitrate ...
Uno, Miyuki, Oba-Shinjo, Sueli Mieko, Silva, Roseli da, Miura, Flavio, Clara, Carlos Afonso, Almeida, José Reynaldo Walther de, Malheiros, Suzana M. F, Bianco, André Macedo, Brandt, Reynaldo, Ribas, Guilherme Carvalhal, Feres, Halim, Dzik, Carlos, Rosemberg, Sérgio, Stavale, João Norberto, Teixeira, Manoel Jacobsen, Marie, Suely K. N   +15 more
openaire   +5 more sources

Favorable role of IDH1/2 mutations aided with MGMT promoter gene methylation in the outcome of patients with malignant glioma

Future Science OA, 2021
Aim: The implications of molecular biomarkers IDH1/2 mutations and MGMT gene promoter methylation were evaluated for prognostic outcome of glioma patients. Materials & methods: Glioma cases were analyzed for IDH1/2 mutations and MGMT promoter methylation
Arshad A Pandith, Iqbal Qasim, Shahid M Baba, Aabid Koul, Wani Zahoor, Dil Afroze, Adil Lateef, Usma Manzoor, Ina A Bhat, Dheera Sanadhya, Abdul R Bhat, Altaf U Ramzan, Fozia Mohammad, Iqra Anwar   +13 more
doaj   +1 more source

IDH1 Promotes Foam Cell Formation by Aggravating Macrophage Ferroptosis

Biology, 2022
Simple Summary In our study, the involvement of IDH1 in atherosclerotic foam cells was explored. Inhibiting macrophage ferroptosis and foam cell formation by knocking down IDH1 is a promising study direction for better understanding the occurrence and ...
Ben Li, Chufan Wang, Peng Lu, Yumeng Ji, Xufeng Wang, Chaoyang Liu, Xiaohu Lu, Xiaohan Xu, Xiaowei Wang   +8 more
semanticscholar   +1 more source

Mutation of Isocitrate Dehydrogenase 1 in Cholangiocarcinoma Impairs Tumor Progression by Inhibiting Isocitrate Metabolism

Frontiers in Endocrinology, 2020
Aim: Isocitrate dehydrogenase 1 (IDH1) is key enzyme involved in cellular metabolism and DNA repair. Mutations in IDH1 occur in up to 25% of cholangiocarcinomas.
Li Su, Xinglong Zhang, Lei Zheng, Miaomiao Wang, Zhifa Zhu, Ping Li   +5 more
doaj   +1 more source