Results 51 to 60 of about 34,512 (245)

IDH1andIDH2Mutations in Gliomas [PDF]

New England Journal of Medicine, 2009
A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase 1 gene (IDH1) in a fraction of such tumors, most frequently in tumors that were known to have evolved from lower-grade gliomas (secondary glioblastomas).We determined the sequence of the ...
B.K. Ahmed Rasheed, Allan H. Friedman, Siân Jones, Victor E. Velculescu, Henry S. Friedman, Darell D. Bigner, Gregory J. Riggins, Kenneth W. Kinzler, Genglin Jin, David A. Reardon, Bert Vogelstein, Roger E. McLendon, Ivan Kos, James E. Herndon, Hai Yan, D. Williams Parsons, Ines Batinic-Haberle, Weishi Yuan   +17 more
openaire   +4 more sources

Molecular profile and its clinical impact of IDH1 mutated versus IDH1 wild type intrahepatic cholangiocarcinoma

Scientific Reports, 2022
AbstractIDH1-mutated cholangiocarcinomas (CCAs) are an interesting group of neoplasia with particular behavior and therapeutic implications. The aim of the present work is to highlight the differences characterizing IDH1m and IDH1wt CCAs in terms of genomic landscape. 284 patients with iCCA treated for resectable, locally advanced or metastatic disease
Rimini, Margherita, Fabregat-Franco, Carles, Burgio, Valentina, Lonardi, Sara, Niger, Monica, Scartozzi, Mario, Rapposelli, Ilario Giovanni, Aprile, Giuseppe, Ratti, Francesca, Pedica, Federica, Verdaguer, Helena, Rizzato, Mario, Nichetti, Federico, Lai, Eleonora, Cappetta, Alessandro, Macarulla, Teresa, Fassan, Matteo, De Braud, Filippo, Pretta, Andrea, Simionato, Francesca, De Cobelli, Francesco, Aldrighetti, Luca, Fornaro, Lorenzo, Cascinu, Stefano, Casadei-Gardini, Andrea   +24 more
openaire   +6 more sources

The ketogenic diet is not effective in preclinical models of IDH1 wild-type and IDH1 mutant glioma [PDF]

, 2020
ABSTRACTInfiltrative gliomas are the most common neoplasms arising in the brain, and remain largely incurable despite decades of research. A subset of these gliomas contains mutations inisocitrate dehydrogenase 1(IDH1mut). This mutation disrupts cellular biochemistry, and IDH1mutgliomas are generally less aggressive than IDH1 wild-type (IDH1wt) gliomas.
Rodrigo Javier, Craig Horbinski
openaire   +2 more sources

HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma

Scientific Reports, 2023
Low-grade and secondary high-grade gliomas frequently contain mutations in the IDH1 or IDH2 metabolic enzymes that are hypothesized to drive tumorigenesis by inhibiting many of the chromatin-regulating enzymes that regulate DNA structure.
Matthew C. Garrett, Rebecca Albano, Troy Carnwath, Lubayna Elahi, Catherine A. Behrmann, Merissa Pemberton, Daniel Woo, Eric O’Brien, Brett VanCauwenbergh, John Perentesis, Sanjit Shah, Matthew Hagan, Ady Kendler, Chuntao Zhao, Aditi Paranjpe, Krishna Roskin, Harley Kornblum, David R. Plas, Q. Richard Lu   +18 more
doaj   +1 more source

Mutant IDH1 and seizures in patients with glioma [PDF]

Neurology, 2017
Because the d-2-hydroxyglutarate (D2HG) product of mutant isocitrate dehydrogenase 1 (IDH1mut) is released by tumor cells into the microenvironment and is structurally similar to the excitatory neurotransmitter glutamate, we sought to determine whether IDH1mut increases the risk of seizures in patients with glioma, and whether D2HG increases the ...
Chen, Hao, Judkins, Jonathon, Thomas, Cheddhi, Wu, Meijing, Khoury, Laith, Benjamin, Carolina G, Pacione, Donato, Golfinos, John G, Kumthekar, Priya, Ghamsari, Farhad, Chen, Li, Lein, Pamela, Chetkovich, Dane M, Snuderl, Matija, Horbinski, Craig   +14 more
openaire   +4 more sources

IDH-1, ATRX AND 1P19Q CO-DELETION IN DIFFUSE GLIOMAS

Pakistan Armed Forces Medical Journal, 2020
Objective: To stratify diffuse gliomas into subtypes including diffuse astrocytomas, oligodendrogliomas and glioblastomas based on recent molecular updates and assess their frequencies in our local subpopulation. Study Design: Cross-sectional study.
Rabia Javed, Noreen Akhtar, Usman Hassan, Mohammad Azam, Asif Loya, Mudassir Hussain, Maryam Hameed, Sumera Butt, Sajid Mushtaq   +8 more
doaj  

Correlation of IDH1 mutation with clinicopathologic factors and prognosis in primary glioblastoma: a report of 118 patients from China. [PDF]

PLoS ONE, 2012
It has been reported that IDH1 (IDH1R132) mutation was a frequent genomic alteration in grade II and grade III glial tumors but rare in primary glioblastoma (pGBM).
Wei Yan, Wei Zhang, Gan You, Zhaoshi Bao, Yongzhi Wang, Yanwei Liu, Chunsheng Kang, Yongping You, Lei Wang, Tao Jiang   +9 more
doaj   +1 more source

Association of TP53 Alteration with Tissue Specificity and Patient Outcome of IDH1-Mutant Glioma

Cells, 2021
Since the initial discovery of recurrent isocitrate dehydrogenase 1 (IDH1) mutations at Arg132 in glioma, IDH1 hotspot mutations have been identified in cholangiocarcinoma, chondrosarcoma, leukemia, and various other types of cancer of sporadic incidence.
Balazs Murnyak, L. Eric Huang
doaj   +1 more source

Redox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS‐NADPH Dysregulation

Advanced Science, EarlyView.
Se deficiency downregulates SELENOT, disrupting mitochondrial function and elevating mtROS to induce glucose metabolic reprogramming, NADPH depletion, cysteine accumulation, and disulfidptosis‐mediated actin cytoskeleton collapse in chicken skeletal muscle.
Huanyi Liu, Hao Wu, Ziyu Zhang, Shiwen Xu, Cong Zhou, Tong Xu   +5 more
wiley   +1 more source

Establishment and molecular profiling of a PDX model of a metachronous brain tumor in a patient with constitutional mismatch repair deficiency with biallelic MSH6 variant

Animal Models and Experimental Medicine, EarlyView.
A 6½‐year‐old girl was diagnosed with a medulloblastoma, SHH activated, subtype 3 and TP53 mutant (somatic). After surgery and chemotherapy, she was monitored with quarterly magnetic resonance imaging (MRI) scans and remained free of disease for almost 4 years.
Daniel Antunes Moreno, Bruna Minniti Mançano, Mirella Baroni, Eric Allison Philot, Felipe Antonio de Oliveira Garcia, Murilo Bonatelli, Flávia Escremim de Paula, Iara Viana Vidigal Santana, Gustavo Ramos Teixeira, Mauricio Yamanari, Luciane Sussuchi da Silva, André Escremim de Paula, Augusto Perazzolo Antoniazzi, Adrian Willig, Xiaobin Xing, Zhenyu Xu, Lucas Lourenço, Carlos Almeida Junior, Silvia Aparecida Teixeira, Rui Manuel Reis   +19 more
wiley   +1 more source