Results 71 to 80 of about 34,512 (245)
IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma
Nature Communications, 2023 IDH1 mutations frequently occur early in human glioma. While IDH1 mutation has been shown to promote gliomagenesis via DNA and histone methylation, little is known regarding its regulation in antiviral immunity.
Xueqin Chen +24 more
doaj +1 more source
LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance We report in this article that c-Myc-mediated repression of lncRNA IDH1-AS1 sustains activation of the Warburg effect by HIF1α under normoxic conditions. IDH1-AS1 would otherwise enhance IDH1 enzymatic activity through promoting its homodimerization, leading to increased production of α-KG, which, along with decreases in ROS ...
Hao Gu +7 more
openaire +3 more sources
The emerging role of Nrf2 in heart failure: From cardioprotection to therapeutic approaches
ESC Heart Failure, EarlyView.Nrf2 signalling is impaired in heart failure, contributing to oxidative stress, mitochondrial dysfunction, and ferroptosis, which drive neurohormonal activation, inflammation, and ischaemia‐reperfusion injury. This loss of Nrf2 activity exacerbates hypertension, diabetic cardiomyopathy, and cardiotoxicity, accelerating progression to overt heart ...
Emiliano Fiori +9 more
wiley +1 more source
IDH1 R132C mutation is detected in clear cell hepatocellular carcinoma by pyrosequencing
World Journal of Surgical Oncology, 2017 Background Isocitrate dehydrogenase 1 (IDH1) mutation is common in low-grade glioma (approximately 80%) and acute myeloid leukemia (approximately 10%).
Jung Hee Lee +11 more
doaj +1 more source
Discovery of novel IDH1-R132C inhibitors through structure-based virtual screening
Frontiers in Pharmacology, 2022 Isocitrate dehydrogenase (IDH) belongs to a family of enzymes involved in glycometabolism. It is found in many living organisms and is one of the most mutated metabolic enzymes.
Chujiao Hu +16 more
doaj +1 more source
Ultrastructural Pathology, 2023 Gliomas are the most common malignant brain tumors with poor prognosis. The WHO's classification recognizes isocitrate dehydrogenase 1 (IDH1) mutant astrocytoma and IDH1-wildtype glioblastoma (GBM). The IDH1 mutation confers a survival advantage over the wildtype.
Haitham H. Maraqah +3 more
openaire +4 more sources
Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs
European Journal of Organic Chemistry, EarlyView.Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar +7 more
wiley +1 more source
IDH1 regulates the expression of interferon pathway-related gene IFIT3 [PDF]
Jichu yixue yu linchuang, 2021 Objective To explore the role of IDH1 in the expression of RNA binding proteins (RBPs) in glioma cell line LN229. Methods Lentivirus was used to construct IDH1 knockdown and control cells, and the expression of IDH1 was validated by RT-qPCR (real ...
TANG Wan-jun, PENG Xiao-zhong, HAN Wei
doaj
Molecular and functional characterization of SMOC1 in IDH1 wild type and IDH1 mutant gliomas
, 2016 Joint-Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN) and the Scandinavian Neuropathological Society (SNS)
Weber, MM +3 more
openaire +2 more sources
Environmental and Molecular Mutagenesis, EarlyView.Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk +4 more
wiley +1 more source