Results 71 to 80 of about 58,205 (308)

EXTH-08. REPLACEMENT OF MICROGLIA BY BRAIN-ENGRAFTED MACROPHAGES PREVENTS MEMORY DEFICITS AFTER THERAPEUTIC WHOLE-BRAIN IRRADIATION [PDF]

, 2019
Microglia have a distinct origin compared to blood circulating myeloid cells. Under normal physiological conditions, microglia are maintained by self-renewal, independent of hematopoietic progenitors. Following genetic or pharmacologic depletion, newborn
Boosalis, Zoe, Chen, David, Feng, Xi, Gupta, Nalin, Gupta, Sonali, Liu, Sharon, Rosi, Susanna   +6 more
core   +1 more source

His‐MMDM: Multi‐Domain and Multi‐Omics Translation of Histopathological Images with Diffusion Models

Advanced Science, EarlyView.
His‐MMDM is a diffusion model‐based framework for scalable multi‐domain and multi‐omics translation of histopathological images, enabling tasks from virtual staining, cross‐tumor knowledge transfer, and omics‐guided image editing. ABSTRACT Generative AI (GenAI) has advanced computational pathology through various image translation models.
Zhongxiao Li, Tianqi Su, Bin Zhang, Wenkai Han, Sibin Zhang, Guiyin Sun, Yuwei Cong, Xin Chen, Jiping Qi, Yujie Wang, Shiguang Zhao, Hongxue Meng, Peng Liang, Xin Gao   +13 more
wiley   +1 more source

IDH-1, ATRX AND 1P19Q CO-DELETION IN DIFFUSE GLIOMAS

Pakistan Armed Forces Medical Journal, 2020
Objective: To stratify diffuse gliomas into subtypes including diffuse astrocytomas, oligodendrogliomas and glioblastomas based on recent molecular updates and assess their frequencies in our local subpopulation. Study Design: Cross-sectional study.
Rabia Javed, Noreen Akhtar, Usman Hassan, Mohammad Azam, Asif Loya, Mudassir Hussain, Maryam Hameed, Sumera Butt, Sajid Mushtaq   +8 more
doaj  

Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas. [PDF]

, 2019
Glioma is recognized to be a highly heterogeneous CNS malignancy, whose diverse cellular composition and cellular interactions have not been well characterized. To gain new clinical- and biological-insights into the genetically-bifurcated IDH1 mutant (mt)
Adkins, Jonathan, Al-Kofahi, Yousef, Barnholtz-Sloan, Jill S, Berens, Michael E, Byron, Sara A, Cho, Sanghee, Couce, Marta, Cuyugan, Lori, Devine, Karen, Dinn, Sean, Ginty, Fiona, Graf, John F, Halperin, Rebecca F, Kiefer, Jeffrey, Kim, Seungchan, Liang, Winnie S, McDonough, Elizabeth, Nasser, Sara, Nelson, Sarah J, Ostrom, Quinn, Phillips, Joanna J, Prados, Michael, Rusu, Mirabela, Schyberg, Shannon, Sloan, Andrew E, Sood, Anup, Wolansky, Leo, Zavodszky, Maria I   +27 more
core   +1 more source

IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma

Nature Communications, 2023
IDH1 mutations frequently occur early in human glioma. While IDH1 mutation has been shown to promote gliomagenesis via DNA and histone methylation, little is known regarding its regulation in antiviral immunity.
Xueqin Chen, Jun Liu, Yuqin Li, Yuequan Zeng, Fang Wang, Zexiong Cheng, Hao Duan, Guopeng Pan, Shangqi Yang, Yuling Chen, Qing Li, Xi Shen, Ying Li, Zixi Qin, Jiahong Chen, Youwei Huang, Xiangyu Wang, Yuli Lu, Minfeng Shu, Yubo Zhang, Guocai Wang, Kai Li, Xi Lin, Fan Xing, Haipeng Zhang   +24 more
doaj   +1 more source

Generalized channels: channels for convex subsets of the state space [PDF]

, 2012
Let $K$ be a convex subset of the state space of a finite dimensional $C^*$-algebra. We study the properties of channels on $K$, which are defined as affine maps from $K$ into the state space of another algebra, extending to completely positive maps on ...
Jencova, Anna
core   +1 more source

Mutant IDH1 and thrombosis in gliomas [PDF]

Acta Neuropathologica, 2016
Mutant isocitrate dehydrogenase 1 (IDH1) is common in gliomas, and produces D-2-hydroxyglutarate (D-2-HG). The full effects of IDH1 mutations on glioma biology and tumor microenvironment are unknown. We analyzed a discovery cohort of 169 World Health Organization (WHO) grade II-IV gliomas, followed by a validation cohort of 148 cases, for IDH1 ...
Dusten Unruh, Steven R. Schwarze, Laith Khoury, Cheddhi Thomas, Meijing Wu, Li Chen, Rui Chen, Yinxing Liu, Margaret A. Schwartz, Christina Amidei, Priya Kumthekar, Carolina G. Benjamin, Kristine Song, Caleb Dawson, Joanne M. Rispoli, Girish Fatterpekar, John G. Golfinos, Douglas Kondziolka, Matthias Karajannis, Donato Pacione, David Zagzag, Thomas McIntyre, Matija Snuderl, Craig Horbinski   +23 more
openaire   +2 more sources

Impact of Mutational Landscape and Burden on RBC Transfusion Response in Patients With Lower‐Risk Myelodysplastic Syndromes (LR‐MDS) in the COMMANDS Study

American Journal of Hematology, EarlyView.
ABSTRACT The COMMANDS trial established luspatercept as a first‐line treatment for anemia in transfusion‐dependent lower‐risk (LR) myelodysplastic syndromes (MDS). Here we report red blood cell (RBC) transfusion response analysis based on somatic mutations profile and disease risk for patients treated with luspatercept or epoetin alfa in the COMMANDS ...
Rami S. Komrokji, Sheida Hayati, Manuel Ugidos, Guillermo Garcia‐Manero, Matteo Giovanni Della Porta, Amer M. Zeidan, Valeria Santini, Uwe Platzbecker, Anita K. Gandhi, Rajasekhar N. V. S. Suragani   +9 more
wiley   +1 more source

IDH1 R132C mutation is detected in clear cell hepatocellular carcinoma by pyrosequencing

World Journal of Surgical Oncology, 2017
Background Isocitrate dehydrogenase 1 (IDH1) mutation is common in low-grade glioma (approximately 80%) and acute myeloid leukemia (approximately 10%).
Jung Hee Lee, Dong Hoon Shin, Won Young Park, Nari Shin, Ahrong Kim, Hyun Jung Lee, Young Keum Kim, Kyung Un Choi, Jee Yeon Kim, Young Il Yang, Chang Hun Lee, Mee Young Sol   +11 more
doaj   +1 more source

IDH1 regulates the expression of interferon pathway-related gene IFIT3 [PDF]

Jichu yixue yu linchuang, 2021
Objective To explore the role of IDH1 in the expression of RNA binding proteins (RBPs) in glioma cell line LN229. Methods Lentivirus was used to construct IDH1 knockdown and control cells, and the expression of IDH1 was validated by RT-qPCR (real ...
TANG Wan-jun, PENG Xiao-zhong, HAN Wei
doaj