Results 41 to 50 of about 11,875 (182)

Clinical characteristics of patients with anti-TIF1-γ antibodies

Rheumatology, 2016
Objectives : Inflammatory myopathies are a group of idiopathic, heterogeneous systemic diseases affecting predominantly skeletal muscles, though they can also involve the skin and internal organs.
Anna Masiak, Julia Kulczycka, Zenobia Czuszyńska, Zbigniew Zdrojewski   +3 more
doaj   +1 more source

Immune Complexes Shape the Pathogenicity of Autoantibodies in Systemic Autoimmune Diseases: Insights From an FcγRIIIA‐Reporter Assay

Arthritis &Rheumatology, EarlyView.
Objective Immune complexes (ICs), formed by autoantigen and autoantibody, play a pathogenic role in systemic autoimmune diseases through stimulation of Fcγ receptors (FcγR). However, studies investigating bioactivity of circulating ICs across various diseases remain limited.
Koji Suzuki, Masaru Takeshita, Yuki Imai, Hiroyuki Fukui, Kazunori Furuhashi, Kotaro Matsumoto, Jun Kikuchi, Keiko Yoshimoto, Yuko Kaneko   +8 more
wiley   +1 more source

Functioning in adult patients with idiopathic inflammatory myopathy: Exploring the role of environmental factors using focus groups.

PLoS ONE, 2021
ObjectiveHealth-related quality of life is impaired in idiopathic inflammatory myopathies. This study aimed to identify the main areas of the health-related quality of life environment domain that are affected in patients with myositis.MethodsA ...
I Armadans-Tremolosa, G Guilera, M Las Heras, A Castrechini, A Selva-O'Callaghan   +4 more
doaj   +1 more source

T Cell Plasticity in Systemic Lupus Erythematosus Revealed by Large‐Scale T Cell Receptor Repertoire and Transcriptome Studies

Arthritis &Rheumatology, EarlyView.
Objective We aimed to characterize CD4+ T cell plasticity in human systemic lupus erythematosus (SLE) by leveraging T cell receptor (TCR) repertoire features as markers of prior lineage states, integrating TCR and transcriptomic profiling to delineate plasticity patterns and evaluate their association with clinical disease activity. Methods We used TCR
Yasuo Nagafuchi, Masahiro Nakano, Kaitlyn A. Lagattuta, Mineto Ota, Hiroaki Hatano, Haruka Takahashi, Takahiro Itamiya, Hajime Inokuchi, Soumya Raychaudhuri, Tomohisa Okamura, Keishi Fujio, Kazuyoshi Ishigaki   +11 more
wiley   +1 more source

Antibodies against Ro52 in idiopathic inflammatory myopathies are associated with objective sicca symptoms

Frontiers in Immunology
Autoantibodies against Ro52 are not only detected in Sjögren’s disease (SjD), but also in idiopathic inflammatory myopathies, where they correlate with the incidence and severity of interstitial lung disease (ILD).
Anna Meinecke, Anna Meinecke, Benjamin Seeliger, Benjamin Seeliger, Jonas C. Schupp, Jonas C. Schupp, Jonas C. Schupp, Jonas C. Schupp, Thomas Skripuletz, Vega Gödecke, Marie-Therese Holzer, Diana Ernst, Torsten Witte   +12 more
doaj   +1 more source

The clinicoserological spectrum of inflammatory myopathy in the context of systemic sclerosis and systemic lupus erythematosus

Indian Journal of Rheumatology, 2020
Autoimmune rheumatic diseases (ARDs) are characterized by a pathological triad composed of autoimmunity/inflammation, microangiopathy, and aberrant tissue remodeling.
John D Pauling, Sarah Skeoch, Julie J Paik   +2 more
doaj   +1 more source

Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathiesResearch in context

EBioMedicine, 2023
Summary: Background: In patients with idiopathic inflammatory myopathies (IIM), autoantibodies are associated with specific clinical phenotypes suggesting a pathogenic role of adaptive immunity.
Valérie Leclair, Angeles S. Galindo-Feria, Simon Rothwell, Olga Kryštůfková, Sepehr Sarrafzadeh Zargar, Herman Mann, Louise Pyndt Diederichsen, Helena Andersson, Martin Klein, Sarah Tansley, Lars Rönnblom, Kerstin Lindblad-Toh, Ann-Christine Syvänen, Marie Wahren-Herlenius, Johanna K. Sandling, Neil McHugh, Janine A. Lamb, Jiri Vencovský, Hector Chinoy, Marie Holmqvist, Matteo Bianchi, Leonid Padyukov, Ingrid E. Lundberg, Lina-Marcela Diaz-Gallo, Matteo Bianchi, Sergey V. Kozyrev, Johanna K. Sandling, Lars Rönnblom, Maija-Leena Eloranta, Ann-Christine Syvänen, Dag Leonard, Johanna Dahlqvist, Maria Lidén, Argyri Mathioudaki, Jennifer RS. Meadows, Jessika Nordin, Gunnel Nordmark, Ingrid E. Lundberg, Antonella Notarnicola, Leonid Padyukov, Anna Tjärnlund, Maryam Dastmalchi, Daniel Eriksson, Øyvind Molberg, Helena Andersson, Kerstin Lindblad-Toh, Fabiana H.G. Farias, Marie Wahren-Herlenius, Awat Jalal, Balsam Hanna, Helena Hellström, Tomas Husmark, Åsa Häggström, Anna Svärd, Thomas Skogh, Louise Pyndt Diederichsen, Janine A. Lamb, Simon Rothwell, Hector Chinoy, Robert G. Cooper, Kerstin Lindblad-Toh, Gerli Rosengren Pielberg, Anna Lobell, Åsa Karlsson, Eva Murén, Kerstin M. Ahlgren, Lars Rönnblom, Maija-Leena Eloranta, Göran Andersson, Nils Landegren, Olle Kämpe, Peter Söderkvis   +71 more
doaj   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Necrotizing Autoimmune Myopathy: A Rare Variant of Idiopathic Inflammatory Myopathies

Journal of Investigative Medicine High Impact Case Reports, 2017
Idiopathic inflammatory myopathies are an unusual group of myopathies with annual incidence of 1 in 100 000 people in the United States. Necrotizing autoimmune myopathy comprises only 16% of this group.
Noman Ahmed Jang Khan MD, Shaza Khalid MD, Saad Ullah MD, Muhammad Umair Malik MD, Samer Makhoul MD   +4 more
doaj   +1 more source

Outcomes in progressive pulmonary fibrosis in systemic autoimmune rheumatic diseases: real‐world data from the ILD‐PRO Registry

Arthritis &Rheumatology, Accepted Article.
Objective We evaluated baseline characteristics, treatment patterns, and outcomes in patients with systemic autoimmune rheumatic disease‐associated progressive pulmonary fibrosis (SARD‐PPF) and evaluated whether outcomes differed by SARD subtype. Methods The ILD‐PRO Registry is a prospective multicenter US registry of patients with PPF.
Sonali J Bracken, Jeremy M Weber, Megan L Neely, Aparna C Swaminathan, Scott M Palmer, Erin M Wilfong, Ann D Chauffe, Elizabeth R Volkmann   +7 more
wiley   +1 more source