Results 51 to 60 of about 12,579 (209)

Recent advances in the immunogenetics of idiopathic inflammatory myopathy [PDF]

, 2011
This review summarizes the previous and current literature on the immunogenetics of idiopathic inflammatory myopathy (IIM) and updates the research progress that has been made over the past decade.
Hector Chinoy, Chinoy, Hector; id_orcid, William ER Ollier, Lamb, Janine A.; id_orcid, Cooper, Robert G., Ollier, William E R, Janine A Lamb, Robert G Cooper   +7 more
core   +1 more source

Immune Complexes Shape the Pathogenicity of Autoantibodies in Systemic Autoimmune Diseases: Insights From an FcγRIIIA‐Reporter Assay

Arthritis &Rheumatology, EarlyView.
Objective Immune complexes (ICs), formed by autoantigen and autoantibody, play a pathogenic role in systemic autoimmune diseases through stimulation of Fcγ receptors (FcγR). However, studies investigating bioactivity of circulating ICs across various diseases remain limited.
Koji Suzuki, Masaru Takeshita, Yuki Imai, Hiroyuki Fukui, Kazunori Furuhashi, Kotaro Matsumoto, Jun Kikuchi, Keiko Yoshimoto, Yuko Kaneko   +8 more
wiley   +1 more source

Clinical characteristics of patients with anti-TIF1-γ antibodies

Rheumatology, 2016
Objectives : Inflammatory myopathies are a group of idiopathic, heterogeneous systemic diseases affecting predominantly skeletal muscles, though they can also involve the skin and internal organs.
Anna Masiak, Julia Kulczycka, Zenobia Czuszyńska, Zbigniew Zdrojewski   +3 more
doaj   +1 more source

Identification of Metabolic Signature Associated with Idiopathic Inflammatory Myopathy Reveals Polyamine Pathway Alteration in Muscle Tissue

Metabolites, 2022
Idiopathic inflammatory myopathy (IIM) is hard to diagnose without a muscle biopsy. We aimed to identify a metabolite panel for IIM detection by metabolomics approach in serum samples and to explore the metabolomic signature in tissue samples from a ...
Jihyun Kang, Jeong Yeon Kim, Youjin Jung, Seon Uk Kim, Eun Young Lee, Joo-Youn Cho   +5 more
doaj   +1 more source

T Cell Plasticity in Systemic Lupus Erythematosus Revealed by Large‐Scale T Cell Receptor Repertoire and Transcriptome Studies

Arthritis &Rheumatology, EarlyView.
Objective We aimed to characterize CD4+ T cell plasticity in human systemic lupus erythematosus (SLE) by leveraging T cell receptor (TCR) repertoire features as markers of prior lineage states, integrating TCR and transcriptomic profiling to delineate plasticity patterns and evaluate their association with clinical disease activity. Methods We used TCR
Yasuo Nagafuchi, Masahiro Nakano, Kaitlyn A. Lagattuta, Mineto Ota, Hiroaki Hatano, Haruka Takahashi, Takahiro Itamiya, Hajime Inokuchi, Soumya Raychaudhuri, Tomohisa Okamura, Keishi Fujio, Kazuyoshi Ishigaki   +11 more
wiley   +1 more source

An unusual case of idiopathic inflammatory myopathy presenting with organizing pneumonia as cavitary lesions

, 2019
A young woman presented with gradually progressive breathlessness, cough and muscle weakness for one and a half year. Her chest radiograph showed multiple, bilateral thin-walled cavitary lesions. Her serum was found to be positive for anti-Jo1 antibodies
Agrawal, Sumita; Department of Pulmonary, Critical Care & Sleep Medicine, VMMC & Safdarjung Hospital, New Delhi, India, Chakrabarti, Shibdas; Department of Pulmonary, Critical Care & Sleep Medicine, VMMC & Safdarjung Hospital, New Delhi, India, Suri, Jagdish Chander; Medeor JCS Institute of Pulmonary, Critical Care & Sleep Medicine, Qutab Institutional Area, New Delhi, India, Gupta, Nitesh; Department of Pulmonary, Critical Care & Sleep Medicine, VMMC & Safdarjung Hospital, New Delhi, India, Kumar, Rohit; Department of Pulmonary, Critical Care & Sleep Medicine, VMMC & Safdarjung Hospital, New Delhi, India, Sen, M. K.; Department of Pulmonary, Critical Care & Sleep Medicine, VMMC & Safdarjung Hospital, New Delhi, India   +5 more
core   +2 more sources

Quantitative nailfold video capillaroscopy in patients with idiopathic inflammatory myopathy [PDF]

, 2010
Objectives. To quantify nailfold capillary density and dimensions in patients with idiopathic inflammatory myopathy (IIM) and compare them with those in healthy controls; to look for associations with microvascular disease in IIM; and to determine ...
Mercer, Louise K., Chinoy, Hector; id_orcid, Murray, Andrea K.; id_orcid, Moore, Tonia L., Herrick, Ariane L., Cooper, Robert G., Vail, Andy; id_orcid   +6 more
core   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Antibodies against Ro52 in idiopathic inflammatory myopathies are associated with objective sicca symptoms

Frontiers in Immunology
Autoantibodies against Ro52 are not only detected in Sjögren’s disease (SjD), but also in idiopathic inflammatory myopathies, where they correlate with the incidence and severity of interstitial lung disease (ILD).
Anna Meinecke, Anna Meinecke, Benjamin Seeliger, Benjamin Seeliger, Jonas C. Schupp, Jonas C. Schupp, Jonas C. Schupp, Jonas C. Schupp, Thomas Skripuletz, Vega Gödecke, Marie-Therese Holzer, Diana Ernst, Torsten Witte   +12 more
doaj   +1 more source

The clinicoserological spectrum of inflammatory myopathy in the context of systemic sclerosis and systemic lupus erythematosus

Indian Journal of Rheumatology, 2020
Autoimmune rheumatic diseases (ARDs) are characterized by a pathological triad composed of autoimmunity/inflammation, microangiopathy, and aberrant tissue remodeling.
John D Pauling, Sarah Skeoch, Julie J Paik   +2 more
doaj   +1 more source