Results 1 to 10 of about 1,394 (181)

Idiopathic multicentric Castleman disease with marrow fibrosis and extramedullary hematopoiesis. [PDF]

Eur J Haematol
AbstractBackgroundIdiopathic multicentric Castleman disease (iMCD) is a rare inflammatory disorder mediated by excessive proinflammatory cytokine signaling, most notably by interleukin 6 (IL‐6). IL‐6‐induced extramedullary hematopoiesis (EMH) has been reported in murine models of iMCD.
Blommers M, Selegean S, Wood RK, Sarmiento Bustamante M, Shyamsundar S, Wiley EA, Comeau E, Shawwa AA, Rose-John S, Fajgenbaum DC, Chen LYC.   +10 more
europepmc   +6 more sources

CXCL13 is a predictive biomarker in idiopathic multicentric Castleman disease [PDF]

Nature Communications, 2022
Idiopathic multicentric Castleman disease (iMCD) is a life-threatening inflammatory disease requiring immediate intervention, for which the recommended first-line therapy is the Interleukin-6 pathway inhibitor siltuximab.
Sheila K Pierson, Melanie D Mumau
exaly   +5 more sources

Idiopathic Multicentric Castleman Disease with Cutaneous Manifestation: Case Report [PDF]

Medicina, 2022
Castleman disease constitutes a rare class of lymphoproliferative disorders, with an estimated incidence of 21 to 25 per million patient years. The idiopathic subtype exhibits a significantly diverse clinical presentation, which can imitate many ...
Christoforos S. Kosmidis, Chrysi Maria Mystakidou, Georgios Koimtzis, Evanthia Papadopoulou, Vasiliki Theodorou, Nikolaos Iason Katsios, Eleni Georgakoudi, Christina Sevva, Ioannis Charalampous, Nikolaos Varsamis, Charilaos Koulouris, Christina Michael, Konstantinos Papadopoulos, Georgios Anthimidis, Sofia Baka   +14 more
doaj   +4 more sources

The Enigma of Idiopathic Multicentric Castleman Disease: An Elusive Diagnosis. [PDF]

Cureus
Castleman disease (CD) is a rare lymphoproliferative disorder encompassing a spectrum of conditions with distinct histopathological findings and varied clinical presentations. Diagnostic challenges are often encountered due to overlapping features with other malignancies, infections, and autoimmune disorders.
Ohemeng-Dapaah J, Onyechi A, Kang A, Lacasse A, Sinha J.   +4 more
europepmc   +5 more sources

Idiopathic multicentric Castleman disease in children: a single-center retrospective analysis. [PDF]

BMC Pediatr
Objective To investigate the clinical features, pathological phenotype, treatment and prognosis of idiopathic multicenter Castleman disease (iMCD)in children. Methods From January 2017 to September 2023, basic information, laboratory tests, treatment and
Du J, Yao J, Ma H, Li L, Wei A, Zhang L, Wang D, Li Z, Zhang R, Wang T.   +9 more
europepmc   +4 more sources

Idiopathic multicentric Castleman disease: A case report

Asian Journal of Medical Sciences
Castleman disease is a rare disease affecting lymph nodes and is considered a non-clonal lymphoproliferative disorder. It has variable clinical presentation and is divided into clinical and histopathological subtypes.
Anna John , Sheima R Das
doaj   +4 more sources

Real-practice management and treatment of idiopathic multicentric Castleman disease with siltuximab: a collection of clinical experiences. [PDF]

Drugs Context, 2014
Castleman disease (CD) is a group of lymphoproliferative disorders that share common histopathological features yet have widely different aetiologies, clinical features and grades of severity as well as treatments and outcomes.
Rossini B, Cecchi N, Clemente F, De Paolis MR, Hohaus S, Innao V, Lucignano M, Massaiu R, Palumbo G, Rigolin GM, Rossi FG, Verga L, Guarini A.   +12 more
europepmc   +4 more sources

Idiopathic Multicentric Hyaline Vascular-Type Castleman Disease [PDF]

Case Reports in Hematology, 2021
Castleman disease is a rare lymphoproliferative disorder presenting with localized or disseminated lymphadenopathy and systemic symptoms. It can be categorized clinically as unicentric or multicentric, histopathologically as hyaline vascular, plasma cell,
Adelaide Moutinho, Rita Gamboa Cunha, Sheila Koch Jamal, Marta Meleiro Lisboa, Sandra Tavares   +4 more
doaj   +4 more sources

Complications and Management of Idiopathic Multicentric Castleman Disease. [PDF]

HCA Healthc J Med
Feustel K, Keeling J, Makos O, Scherbak D.   +3 more
europepmc   +4 more sources

Idiopathic multicentric Castleman disease

Journal of Cancer Research and Therapeutics, 2023
ABSTRACT An elderly man presented with fever and chills for six months, associated with loss of appetite and weight loss, bilateral edema, and non-tender inguinal lymphadenopathy. The left-sided testicle was bulky, firm, and non-tender.
Vipul Chaudhari, Simran Thakkar, Namita Padwal, Niteen D Karnik   +3 more
openalex   +3 more sources