Results 71 to 80 of about 1,394 (181)

Successful outcome in a case of idiopathic multicentric Castleman disease with atypical lymphadenopathy and kidney injury: Diagnostic challenges and treatment approach—Case report

SAGE Open Medical Case Reports
Idiopathic multicentric Castleman disease is a rare and complex disease characterized by systemic inflammation, lymphadenopathy, and multiorgan involvement. This case report presents a 66-year-old Chinese man with idiopathic multicenter Castleman disease
Dilina Yalikun, Jing Zhuang, Wei Lei, Chun Wang, Ailima Aierken, Yue Qu, Junyan Wang, Xuefei Tian, Hong Jiang   +8 more
doaj   +1 more source

TAFRO Syndrome and Elusive Diagnosis of Idiopathic Multicentric Castleman Disease Treated with Empiric Anti-Interleukin-6 Therapy

Case Reports in Oncology, 2021
TAFRO syndrome is defined by the presence of thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis/renal dysfunction (R), and organomegaly (O) and can be seen with idiopathic multicentric Castleman disease (iMCD) or as an isolated process ...
Corinne Williams, Alexis Phillips, Vikram Aggarwal, Liron Barnea Slonim, David C. Fajgenbaum, Reem Karmali   +5 more
doaj   +1 more source

Comprehensive analysis of 65 patients with Castleman disease in a single center in China

Scientific Reports, 2022
This study aimed to investigate the epidemiologic, clinical, pathological characteristics, and treatment of patients with Castleman disease (CD) in a single center in China.
Xi-Qian Wang, Nian-Nian Zhong, Qi Sun, Si-Chen Yan, Guang-Cai Xu, Yong-Gong Wang, Li-Wei Peng, Bing Liu, Lin-Lin Bu   +8 more
doaj   +1 more source

Radiological and Pathological Features of Cyst Formation in Idiopathic Multicentric Castleman Disease

Advances in Respiratory Medicine, 2023
Introduction: Idiopathic multicentric Castleman disease (MCD) has been reported to form lung cysts at a relatively high rate. However, the radiological and pathological features of cystic formation in MCD are unclear. Methods: To clarify these questions,
Ryota Otoshi, Akimasa Sekine, Tatsuya Muraoka, Tae Iwasawa, Tamiko Takemura, Shoichiro Matsushita, Koji Okudela, Hideya Kitamura, Tomohisa Baba, Takashi Ogura   +9 more
doaj   +1 more source

Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease [PDF]

, 2021
Sheila K. Pierson, Sushila Shenoy, Ana B. Oromendia, Alexander Gorzewski, Ruth-Anne Langan Pai, Christopher S. Nabel, Jason R. Ruth, Sophia A. T. Parente, Daniel J. Arenas, Mary Guilfoyle, Manjula Reddy, Michael E. Weinblatt, Nancy A. Shadick, Mark Bower, Alessia Dalla Pria, Yasufumi Masaki, Laura M. Katz, Jason G. Mezey, Philip Beineke, David Lee, Craig Tendler, Taku Kambayashi, Alexander Fosså, Frits van Rhee, David C. Fajgenbaum   +24 more
openalex   +1 more source

Follicular Dendritic Cell Sarcoma of the Parapharyngeal Space Arising in Association With Castleman Disease

Pathology International, Volume 75, Issue 5, Page 236-242, May 2025.
Histopathological and immunohistochemical findings from the excisional biopsy of a right parapharyngeal mass in a 56‐year‐old woman with follicular dendritic cell sarcoma arising in Castleman disease. (A) H&E staining reveals atypical tumor cells intimately admixed with lymphocytes. (B) Adjacent areas show “lollipop lesions” characteristic of Castleman
Shunsuke Koga, Wei Du, Gabriel C. Caponetti, Kumarasen Cooper   +3 more
wiley   +1 more source

Exploring the Clinical Diversity of Castleman Disease and TAFRO Syndrome: A Japanese Multicenter Study on Lymph Node Distribution Patterns

American Journal of Hematology, Volume 100, Issue 4, Page 592-605, April 2025.
ABSTRACT Individuals diagnosed with Castleman disease (CD) and TAFRO syndrome (characterized by thrombocytopenia, anasarca, fever, bone marrow fibrosis, and organomegaly) displays a wide range of clinical symptoms, including varying patterns of lymph node enlargement, systemic inflammation, and impaired organ function.
Mizuna Otsuka, Tomohiro Koga, Remi Sumiyoshi, Shoichi Fukui, Yuko Kaneko, Takayuki Shimizu, Atsushi Katsube, Shingo Yano, Yasufumi Masaki, Makoto Ide, Hajime Yoshifuji, Masayasu Kitano, Yasuharu Sato, Naoki Sawa, Hiroaki Niiro, Naoya Nakamura, David C. Fajgenbaum, Frits van Rhee, Atsushi Kawakami   +18 more
wiley   +1 more source

STAT3 Signaling Pathway in Health and Disease

MedComm, Volume 6, Issue 4, April 2025.
An image depicting the role of STAT3 in various human diseases ABSTRACT Signal transducer and activator of transcription 3 (STAT3) is a critical transcription factor involved in multiple physiological and pathological processes. While STAT3 plays an essential role in homeostasis, its persistent activation has been implicated in the pathogenesis of ...
Md Abdus Samad, Iftikhar Ahmad, Aakifah Hasan, Mohammad Hassan Alhashmi, Arusha Ayub, Fahad A. Al‐Abbasi, Ajoy Kumer, Shams Tabrez   +7 more
wiley   +1 more source

Single‐center off‐label benralizumab use for refractory hypereosinophilic syndrome demonstrates satisfactory safety and efficacy

eJHaem, Volume 6, Issue 1, February 2025.
Abstract Introduction Benralizumab is an interleukin 5‐receptor‐blocking drug registered for the treatment of eosinophilic asthma. It has proven efficient and safe in a small phase‐II trial in hypereosinophilic syndrome and is currently being investigated in a larger, randomized phase‐III trial.
Yvonne Veltman, Anna M. Aalbers, Maud A. W. Hermans, Pim G. N. J. Mutsaers   +3 more
wiley   +1 more source

Insights into laryngeal Castleman disease: A comprehensive scoping review with a case study focus

Laryngoscope Investigative Otolaryngology, Volume 10, Issue 1, February 2025.
This scoping review highlights the trends in evaluation, diagnosis, and management of laryngeal Castleman disease through description of five previously described cases and the addition of one case from Mayo Clinic Florida. Given the rarity of laryngeal CD, its identification and management can be a challenge.
Natalie Weiss, Estephania Candelo, Margaret Bridges, Amy Rutt   +3 more
wiley   +1 more source