Results 51 to 60 of about 14,741 (259)

Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes

Advanced Science, EarlyView.
Skull bone (calvarium) marrow in diabetic mice stay structurally intact and keeps making blood cells, unlike the bone marrow of the leg bones. The skull marrow is exposed to cerebrospinal fluid (CSF), which contains protective molecules called oxysterols.
Bright Asare‐Bediako, Sergio Li Calzi, Julia G. Behnsen, Ram Prasad, Magdalena Blaszkiewicz, Yvonne Adu‐Rutledge, Robert F. Rosencrans, Jason L. Floyd, Ashley Rennhack, Denise Stanford, Anna Lin, Todd A. Lydic, Carl M. Sheridan, Michael E. Boulton, Kristy L. Townsend, Julia V. Busik, Maria B. Grant   +16 more
wiley   +1 more source

Development of the Brazilian Portuguese version of the “Grading scale for idiopathic normal pressure hydrocephalus”: cross-cultural adaptation, reliability and validity

Arquivos de Neuro-Psiquiatria
Objective: The current study translated to Portuguese and validated the normal pressure hydrocephalus (NPH) scale originally developed in English as the Grading Scale for Idiopathic Normal Pressure Hydrocephalus.
Maria Izabel Romão Lopes, Juliana Benevenuto Tornai, Fernanda Letkaske de Miranda Jeng, Bianca di Virgilio Lopes, Gabriel André da Silva Mendes, Matheus Fernandes de Oliveira, Fernando Campos Gomes Pinto   +6 more
doaj   +1 more source

Are brain displacements and pressures within the parenchyma induced by surface pressure differences? A computational modelling study.

PLoS ONE, 2023
The intracranial pressure is implicated in many homeostatic processes in the brain and is a fundamental parameter in several diseases such as e.g. idiopathic normal pressure hydrocephalus.
Eleonora Piersanti, Marie E Rognes, Vegard Vinje   +2 more
doaj   +1 more source

Biopsies from Idiopathic Normal Pressure Hydrocephalus Patients as a Window to the Events of Early Alzheimer's disease: Beta‐amyloid and Tau Pathologies Alter Synaptic Transmission in Human Brain [PDF]

Alzheimers Dement
Abstract Background The molecular mechanisms leading to Alzheimer's disease (AD) are poorly known. This is due to the lack of human tissue samples for research representing early changes of AD pathology, raising a need for development of novel human‐based preclinical models for AD. Idiopathic normal pressure hydrocephalus (iNPH) is an neurodegenerative
Dougalis A, Abushik P, Pelkonen A, Giudice L, Gomez‐Budia M, Novosolova N, Välimäki N, Rezaie M, Nurkhametova D, Giniatullina R, Shakirzyanova A, Mali A, de Kock C, Mertens E, Mansvelder H, Stevens B, Macosko E, Hiltunen M, Rauramaa T, Leinonen V, Malm T.   +20 more
europepmc   +2 more sources

Shunting for idiopathic normal pressure hydrocephalus. [PDF]

Cochrane Database Syst Rev
Normal pressure hydrocephalus (NPH) occurs when the brain ventricles expand, causing a triad of gait, cognitive, and urinary impairment. It can occur after a clear brain injury such as trauma, but can also occur without a clear cause (termed idiopathic, or iNPH). Non-randomised studies have shown a benefit from surgically diverting ventricular fluid to
Pearce RKB, Gontsarova A, Richardson D, Methley AM, Watt HC, Tsang K, Carswell C.   +6 more
europepmc   +4 more sources

Open-aqueduct LOVA, LIAS, iNPH: a comparative clinical-radiological study exploring the "grey zone" between different forms of chronic adulthood hydrocephalus [PDF]

, 2022
The definition of chronic adult hydrocephalus encompasses different pathological entities with overlapping characteristics, including long-standing overt ventriculomegaly in adults (LOVA), late-onset idiopathic aqueductal stenosis (LIAS) and idiopathic ...
Albini-Riccioli, Luca, Carretta, Alessandro, Conti, Alfredo, Elder, Benjamin D, Giannini, Giulia, La Corte, Emanuele, Mantovani, Paolo, Martinoni, Matteo, Mazzatenta, Diego, Palandri, Giorgio, Tonon, Caterina   +10 more
core   +1 more source

Clinical and Radiological Evolution of Idiopathic Normal Pressure Hydrocephalus: A Critical Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background The pathophysiology of idiopathic normal pressure hydrocephalus (iNPH) remains poorly understood. While it is commonly accepted that iNPH has an insidious onset, little is known about its preclinical and early stages and its development over time.
David Campo‐Caballero, Elissa Ash, Alfonso Fasano, Davide Martino, Mats Tullberg, Araceli Alonso Canovas, Joachim K. Krauss   +6 more
wiley   +1 more source

Charlson comorbidity index applied to shunted idiopathic normal pressure hydrocephalus

Scientific Reports, 2023
A series of epidemiological studies have shown the limited life expectancy of patients suffering from idiopathic normal pressure hydrocephalus (iNPH). In most cases, comorbid medical conditions are the cause of death, rather than iNPH. Though it has also
Petra M. Klinge, Kevin L. Ma, Owen P. Leary, Rahul A. Sastry, Shanzeh Sayied, Ollin Venegas, Thomas Brinker, Ziya L. Gokaslan   +7 more
doaj   +1 more source

Exploring Theory of Mind abilities in patients with probable idiopathic normal pressure hydrocephalus

Journal of Neuropsychology, EarlyView.
Abstract This study investigated Theory of Mind (ToM) deficits in patients with suspected idiopathic normal pressure hydrocephalus (iNPH), a condition affecting motor, cognitive and autonomic functions. Given the overlap between ToM‐related neural networks and those affected in iNPH, we examined whether ToM impairments are a feature of the disease ...
Akrivi Vatsi, George Stranjalis, Stylianos Gkatzonis, Christos Koutsarnakis, Eleftherios Neromyliotis, Aristotelis Kalyvas, Ion N. Beratis, Evangelos Drosos, Spyridon Komaitis, Evangelia Liouta   +9 more
wiley   +1 more source

Decrease of excessive daytime sleepiness after shunt treatment for normal pressure hydrocephalus

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleepiness and apathy are often reported in patients with normal pressure hydrocephalus. However, research on outcomes after shunt surgery has mainly focused on the classical triad symptoms, that is, gait, cognition, and bladder dysfunction. This study aimed to describe the effects of shunt treatment on excessive daytime sleepiness and whether ...
Simon Lidén, Anna Lindam, Dan Farahmand, Anne‐Marie Landtblom, Katarina Laurell   +4 more
wiley   +1 more source