Results 41 to 50 of about 64,344 (120)

Diffuse pulmonary ossification associated with fibrosing interstitial lung disease

Respiratory Medicine Case Reports, 2019
Diffuse pulmonary ossification (DPO) is a rare condition that presents with metaplastic mature bone formation in the pulmonary parenchyma. DPO is usually associated with cardiovascular or respiratory disease.
Badreeddine Alami, Bouchra Amara, Meryem Haloua, Moulay Youssef Alaoui Lmrani, Mounia Serraj, Meryem Boubou, Mustapha Maaroufi   +6 more
doaj   +1 more source

DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis

Cells, 2019
Idiopathic pulmonary fibrosis (IPF) has been linked to chronic lung inflammation. Drosha ribonuclease III (DROSHA), a class 2 ribonuclease III enzyme, plays a key role in microRNA (miRNA) biogenesis.
Soo Jung Cho, Kyoung Sook Hong, Ji Hun Jeong, Mihye Lee, Augustine M. K. Choi, Heather W. Stout-Delgado, Jong-Seok Moon   +6 more
doaj   +1 more source

Genetically predicted expression and idiopathic pulmonary fibrosis: A Mendelian randomization mediation study of and pulmonary function

Journal of International Medical Research
Objective To evaluate the association between genetically predicted GLP-1R expression and idiopathic pulmonary fibrosis and to explore potential mediation through JAKMIP3 and pulmonary-function traits using Mendelian randomization. Methods We conducted a
Gaofeng Liang, Dongchen Tian, Keyun Zhu, Yingxi Li, Jing Zeng, Yan Shen, Zhaohui Chen, Yao Tian   +7 more
doaj   +1 more source

Ambulatory Oxygen for Pulmonary Fibrosis (OxyPuF): a randomised controlled trial and acceptability study

Health Technology Assessment
Introduction Idiopathic pulmonary fibrosis is a devastating condition of unknown cause that results in progressive, irreversible scarring of the lung, manifesting as breathlessness and dry cough. Idiopathic pulmonary fibrosis is thought to be responsible
Rachel L Adams, Alisha Maher, Nicola Gale, Anjali Crawshaw, David Thickett, Alice M Turner   +5 more
doaj   +1 more source

Idiopathic Interstitial Pneumonia as a Possible Cause of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Case Report

Archives of Rheumatology, 2018
There are conflicting data to date on the causal relationship between idiopathic interstitial pneumonia and antineutrophil cytoplasmic antibody (ANCA): (1) myeloperoxidase-ANCA may play a pathogenetic role in pulmonary fibrosis, or (2) pulmonary ...
Hiroshi OIWA, Katsuhiro OOI, Tetsu OYAMA, Eiji SUGYAMA   +3 more
doaj   +1 more source

Fatty acid synthase inhibition alleviates lung fibrosis via β-catenin signal in fibroblasts

Life Science Alliance
Idiopathic pulmonary fibrosis (IPF) is a fatal disease marked by activated fibroblasts. This study shows fatty acid synthase (FASN) inhibition induces quiescent fibroblasts, reduces β-catenin, and alleviates pulmonary fibrosis, suggesting FASN as a ...
Hui Lian, Yujie Zhang, Zhao Zhu, Ruyan Wan, Zhixia Wang, Kun Yang, Shuaichen Ma, Yaxuan Wang, Kai Xu, Lianhui Cheng, Wenyu Zhao, Yajun Li, Lan Wang, Guoying Yu   +13 more
doaj   +1 more source

Basal Cells Contribute to Pulmonary Fibrosis via SP1‐Mediated Senescence‐Associated Secretory Phenotype

The Clinical Respiratory Journal
Idiopathic pulmonary fibrosis is a progressive interstitial lung disease with limited treatment options and poor prognosis. Increasing evidence suggests that airway epithelial remodeling contributes to disease pathogenesis, yet the role of basal cells ...
Xiaoyan Wang, Yupeng Li, Ling Zhao, Xinran Zhang, Min Liu, Huaping Dai   +5 more
doaj   +1 more source

Breaking the invisible cage: social isolation and coping strategies among patients with idiopathic pulmonary fibrosis

BMC Pulmonary Medicine
Background Idiopathic pulmonary fibrosis is a progressive disease that profoundly impacts patients’ psychosocial well-being. Social isolation is a significant but often overlooked challenge in this population.
Shengnan Xu, Lingxi Chen, Ning LIU, Xiang Fang, Yue Zhang, Xi Zhan, Bixuan Yan, Yanling Ding, Siyan Zhan, Hongling Chu, Yunxian Zhou   +10 more
doaj   +1 more source

Blocking endothelin: breaking new ground

European Respiratory Review, 2007
Endothelin is one of a number of profibrotic cytokines and growth factors, along with transforming growth factor-beta, connective tissue growth factor and tumour necrosis factor-alpha, thought to be involved in the pathogenesis of idiopathic pulmonary ...
R. M. du Bois
doaj  

Pirfenidone treatment of idiopathic pulmonary fibrosis

Therapeutics and Clinical Risk Management, 2011
Ye Gan1,2, Erica L Herzog2, Richard H Gomer31Department of Medicine, Central South University, Changsha, Hunan, China; 2Department of Medicine, Yale University School of Medicine, New Haven, CT, USA; 3Department of Biology, Texas A&M University ...
Ye Gan, Erica L Herzog, Richard H Gomer
doaj