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Idiopathic short stature and scoliosis in children treated with growth hormone.
The Bone & Joint Journal, 2023The prevalence of scoliosis is not known in patients with idiopathic short stature, and the impact of treatment with recombinant human growth hormone on those with scoliosis remains controversial.
Haofeng Hong +7 more
semanticscholar +1 more source
Journal of Pediatric Endocrinology and Metabolism, 2001
Abstract Idiopathic short stature (ISS) is a term used to describe the status of children with short stature that cannot be attributed to a specific cause. Many children diagnosed as having ISS have partial GH insensitivity, which can result from disturbances at various points of the GH-IGF-I axis.
PASQUINO AM +10 more
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Abstract Idiopathic short stature (ISS) is a term used to describe the status of children with short stature that cannot be attributed to a specific cause. Many children diagnosed as having ISS have partial GH insensitivity, which can result from disturbances at various points of the GH-IGF-I axis.
PASQUINO AM +10 more
openaire +3 more sources
Endocrinology and Metabolism Clinics of North America, 2005
The diagnostic term, idiopathic short stature, has emerged over the past 30 years and refers to children with short stature of unknown etiology. Controversy exists regarding the scope of the diagnosis and options for its treatment. This article reviews origins of the diagnosis idiopathic short stature and current diagnostic criteria, scientific ...
Rose Gubitosi-Klug, Leona Cuttler
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The diagnostic term, idiopathic short stature, has emerged over the past 30 years and refers to children with short stature of unknown etiology. Controversy exists regarding the scope of the diagnosis and options for its treatment. This article reviews origins of the diagnosis idiopathic short stature and current diagnostic criteria, scientific ...
Rose Gubitosi-Klug, Leona Cuttler
openaire +3 more sources
Short stature homeoboxcontaining gene and idiopathic short stature
Expert Review of Endocrinology & Metabolism, 2009The term idiopathic short stature (ISS) refers to patients who are short due to various unknown reasons. Although it is clear that multiple factors contribute to final height, genetic factors play a crucial role. Mutations of a human homeobox gene, short stature homeobox-containing (SHOX) gene, have been shown to be associated with the short stature ...
IUGHETTI, Lorenzo +6 more
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Idiopathic Short Stature in Children
Pediatric Annals, 2004Despite a lack of clear etiology or diagnostic tests, treatment for this condition should not be ...
Bradley S. Miller, Donald Zimmerman
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New England Journal of Medicine, 2006
A healthy, active 12-year-old boy is in the first percentile for height (133.0 cm [52.4 in.]; −2.25 SD) and the third percentile for weight (29 kg [64 lb]). His physical examination is unremarkable, with normal proportions and no signs of puberty. His bone age is 10 years. His midparental height is 164.5 cm (64.8 in.), and his predicted height is 163.8
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A healthy, active 12-year-old boy is in the first percentile for height (133.0 cm [52.4 in.]; −2.25 SD) and the third percentile for weight (29 kg [64 lb]). His physical examination is unremarkable, with normal proportions and no signs of puberty. His bone age is 10 years. His midparental height is 164.5 cm (64.8 in.), and his predicted height is 163.8
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2011
Idiopathic short stature is a condition in which the height of the individual is more than 2 SD below the corresponding mean height for a given age, sex, and population, and in whom no identifiable disorder is present. It can be subcategorized into familial and non-familial ISS, according to information on delay of puberty and bone age.
Joachim Wölfle +2 more
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Idiopathic short stature is a condition in which the height of the individual is more than 2 SD below the corresponding mean height for a given age, sex, and population, and in whom no identifiable disorder is present. It can be subcategorized into familial and non-familial ISS, according to information on delay of puberty and bone age.
Joachim Wölfle +2 more
openaire +2 more sources
JAMA, 2014
Approximately 2% of children are defined as having short stature. Deciding when to pursue recombinant human growth hormone therapy to increase adult height is controversial.To review the management of children with idiopathic short stature, including diagnostic evaluation and therapeutic options.Systematic literature search of PubMed, Embase, and the ...
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Approximately 2% of children are defined as having short stature. Deciding when to pursue recombinant human growth hormone therapy to increase adult height is controversial.To review the management of children with idiopathic short stature, including diagnostic evaluation and therapeutic options.Systematic literature search of PubMed, Embase, and the ...
openaire +3 more sources
Acta bio-medica : Atenei Parmensis, 2020
Objectives: To assess the long-term effect of growth hormone (GH) therapy in a large cohort of short children with different etiologies. Patients and Methods: We evaluated retrospectively the anthropometric data of 252 short children [height SDS
Adnan Al Shaikh +6 more
semanticscholar +1 more source
Objectives: To assess the long-term effect of growth hormone (GH) therapy in a large cohort of short children with different etiologies. Patients and Methods: We evaluated retrospectively the anthropometric data of 252 short children [height SDS
Adnan Al Shaikh +6 more
semanticscholar +1 more source
The molecular basis of idiopathic short stature
Growth Hormone & IGF Research, 2005Forty years ago, when growth hormone (GH) first became available for use, the molecular basis for growth hormone deficiency (GHD) was entirely unknown. Despite continued difficulties with the biochemical diagnosis of GHD, we now accept the existence of underlying genetic abnormalities as the basis for disorders involving GH secretion.
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