Results 91 to 100 of about 112,361 (357)

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

open access: yesAdvanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang   +2 more
wiley   +1 more source

Theoretical Analysis of Interference Effect From Idle Cells in Ultra-Dense Small Cell Networks

open access: yesIEEE Access, 2018
One of the key characteristics in ultra-dense small cell networks (UDNs) is the advent of idle cells which have no associated user equipment (UE). Indeed, idle cells always transmit the cell-specific reference signal (CRS), while they do not transmit ...
Yosub Park, Daesik Hong
doaj   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

open access: yesAdvanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian   +7 more
wiley   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

open access: yesAdvanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély   +5 more
wiley   +1 more source

Efficient and Robust Heterostructure CeZrOx/NiO‐Ni Inverse Catalyst for Sustainable Photothermal CO2 Methanation

open access: yesAdvanced Science, EarlyView.
A heterostructured CeZrOx/NiO‐Ni inverse catalyst is designed for highly efficient photothermal CO2 methanation under low‐intensity light without auxiliary heating. It achieves 464 mmol·gcat−1·h−1 methane space‐time yield under natural concentrated sunlight, maintains stability over light‐dark cycles and extended air storage, and is scalable to 100 g ...
Chuqiao Song   +16 more
wiley   +1 more source

Epistemic Contextualism: An Idle Hypothesis

open access: yes, 2017
Epistemic contextualism is one of the most hotly debated topics in contemporary epistemology. Contextualists claim that ‘know’ is a context-sensitive verb associated with different evidential standards in different contexts. Contextualists motivate their
John Turri
semanticscholar   +1 more source

Broadband Achromatic Programmable Electromagnetic Camouflage via Fluidic‐Accessible Metasurface

open access: yesAdvanced Science, EarlyView.
A fluidic access metasurface enables dynamic, broadband electromagnetic illusions. By physically reconstructing conductive patterns with liquid metal, the metasurface achieves real‐time, pixel‐level control over phase dispersion. This allows for the programmable generation of arbitrary strong scattering point arrays, effectively deceiving high ...
Shipeng Liu   +14 more
wiley   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

open access: yesAdvanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen   +14 more
wiley   +1 more source

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