Results 121 to 130 of about 87,805 (279)

Iterative Modeling via Structural Diffusion (IMSD): Exploring Fold‐Switching Pathways in Metamorphic Proteins Using AlphaFold2‐Based Generative Diffusion Model UFConf

open access: yesProteins: Structure, Function, and Bioinformatics, Volume 94, Issue 2, Page 633-648, February 2026.
ABSTRACT Metamorphic proteins (MPs) can fold into two or more distinct spatial structures. Increasing interest in MPs has spurred the search for computational tools to predict proteins fold‐switching potential and model their refolding pathways. Here we address this problem by using the recently reported generative diffusion predictor UFConf, based on ...
Dmitrii A. Luzik, Nikolai R. Skrynnikov
wiley   +1 more source

Metal‐Coordination Specificity and Structural Dynamics of C. elegans Metallothionein I: Insights From 3D Modeling and MD Simulations

open access: yesProteins: Structure, Function, and Bioinformatics, Volume 94, Issue 2, Page 620-632, February 2026.
ABSTRACT Metallothioneins (MTLs) are small, cysteine‐rich proteins known for their ability to bind metal ions and exhibit flexible, disordered structures. The structural and functional characteristics of metallothionein I (MTL‐1) from Caenorhabditis elegans were investigated, focusing on its behavior in both metal free (MTL‐1 Apo) and metal‐bond states
Nilvea Ramalho de Oliveira   +4 more
wiley   +1 more source

Humanitarian Crises and Mental Health Coping Strategies Among Myanmar Refugees in Mizoram State, India

open access: yesAsian Social Work and Policy Review, Volume 20, Issue 1, February 2026.
ABSTRACT The Myanmar military coup in February 2021 exacerbated the existing severe humanitarian crisis, resulting in the displacement of over 3.5 million civilians as of June 2025. Additionally, 78,731 individuals sought asylum in neighboring India as of 2023, fleeing the persecution and armed conflict in their homeland.
Tual Sawn Khai
wiley   +1 more source

Peer to Peer Optimistic Collaborative Editing on XML-like trees

open access: yes, 2008
Collaborative editing consists in editing a common document shared by several independent sites. This may give rise to conficts when two different users perform simultaneous uncompatible operations.
Lugiez, Denis, Martin, Stéphane
core   +2 more sources

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

open access: yesFEBS Open Bio, Volume 16, Issue 1, Page 25-40, January 2026.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó   +7 more
wiley   +1 more source

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 2, 14 January 2026.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo   +3 more
wiley   +1 more source

Structural Interface Engineering Unlocks Native‐Like Mechanics in Biomimetic Intervertebral Discs

open access: yesAdvanced Materials Interfaces, Volume 13, Issue 1, 7 January 2026.
Engineered interlamellar and radial fibrous interfaces enable biomimetic intervertebral disc constructs to replicate native mechanical behavior. Suture‐reinforced laminates enhance cohesion and shear strength, while radial fibers improve compressive resilience and stress redistribution.
Haim S. Mordechai   +3 more
wiley   +1 more source

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