Results 121 to 130 of about 97,112 (316)

Engaging the Community: CASP Special Interest Groups

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The Critical Assessment of Structure Prediction (CASP) brings together a diverse group of scientists, from deep learning experts to NMR specialists, all aimed at developing accurate prediction algorithms that can effectively characterize the structural aspects of biomolecules relevant to their functions.
Arne Elofsson, Rachael C. Kretsch, Marcin Magnus, Gaetano T. Montelione   +3 more
wiley   +1 more source

Analyzing the BrowserID SSO System with Primary Identity Providers Using an Expressive Model of the Web [PDF]

, 2015
BrowserID is a complex, real-world Single Sign-On (SSO) System for web applications recently developed by Mozilla. It employs new HTML5 features (such as web messaging and web storage) and cryptographic assertions to provide decentralized login, with the
Fett, Daniel, Kuesters, Ralf, Schmitz, Guido   +2 more
core  

NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals

Nucleic Acids Research, 2010
Mammalian inosine triphosphatase encoded by ITPA gene hydrolyzes ITP and dITP to monophosphates, avoiding their deleterious effects. Itpa− mice exhibited perinatal lethality, and significantly higher levels of inosine in cellular RNA and deoxyinosine in ...
Nona Abolhassani, T. Iyama, D. Tsuchimoto, K. Sakumi, M. Ohno, M. Behmanesh, Y. Nakabeppu   +6 more
semanticscholar   +1 more source

Responses to Ligand Binding in the Bacterial DNA Sliding Clamp “β‐Clamp” Manifest in Dynamic Allosteric Effects

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The homo‐dimeric, ring‐shaped bacterial DNA sliding clamp, β‐clamp, is a central hub in DNA replication and repair. It interacts with a plethora of proteins via their short linear motifs, binding to the same hydrophobic binding pocket on β‐clamp. Although the structure, functions, and interactions of β‐clamp have been amply studied, less focus
Signe Simonsen, Andreas Prestel, Eva C. Østerlund, Marit Otterlei, Thomas J. D. Jørgensen, Birthe B. Kragelund   +5 more
wiley   +1 more source

Critical Assessment of Protein Intrinsic Disorder Round 3 ‐ Predicting Disorder in the Era of Protein Language Models

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Intrinsic disorder (ID) in proteins is a complex phenomenon, encompassing a continuum from entirely disordered regions to structured domains with flexible segments. The absence of a ground truth for all forms of disorder, combined with the possibility of structural transitions between ordered and disordered states under specific conditions ...
Mahta Mehdiabadi, Alessio Del Conte, Maria Victoria Nugnes, Maria Cristina Aspromonte, Silvio C. E. Tosatto, Damiano Piovesan   +5 more
wiley   +1 more source

An introduction to the interim digital SAR processor and the characteristics of the associated Seasat SAR imagery [PDF]

Basic engineering data regarding the Interim Digital SAR Processor (IDP) and the digitally correlated Seasat synthetic aperature radar (SAR) imagery are presented.
Barkan, B., Huneycutt, B., Leang, C., Pang, S., Wu, C.   +4 more
core   +1 more source

The Role of Public Participation in the Development of Integrated Development Plan (in the Vhembe District Municipality

Jurnal Public Policy
The study's primary goal was to assess the role of public participation in developing the Integrated Development Plan (IDP) in a selected Municipality in South Africa.
Tsakani Makumu, Victor H Mlambo
doaj   +1 more source

Iterative Modeling via Structural Diffusion (IMSD): Exploring Fold‐Switching Pathways in Metamorphic Proteins Using AlphaFold2‐Based Generative Diffusion Model UFConf

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Metamorphic proteins (MPs) can fold into two or more distinct spatial structures. Increasing interest in MPs has spurred the search for computational tools to predict proteins fold‐switching potential and model their refolding pathways. Here we address this problem by using the recently reported generative diffusion predictor UFConf, based on ...
Dmitrii A. Luzik, Nikolai R. Skrynnikov
wiley   +1 more source

Unimodality Problems in Ehrhart Theory

, 2017
Ehrhart theory is the study of sequences recording the number of integer points in non-negative integral dilates of rational polytopes. For a given lattice polytope, this sequence is encoded in a finite vector called the Ehrhart $h^*$-vector. Ehrhart $h^*
A. Stapledon, Adam McCabe, Akihiro Higashitani, Alexander Postnikov, C. Bey, C. Haase, Carla D. Savage, Carla D. Savage, Christos A. Athanasiadis, E. Ehrhart, E. Katz, Federico Ardila, Francesco Brenti, H. Ohsugi, Hidefumi Ohsugi, I.M. Gelfand, Jan Schepers, Jeffrey C. Lagarias, Jesús A. De Loera, Jesús A. De Loera, Joseph Gubeladze, M. Beck, M. Hochster, M. Kreuzer, M. Mustaţǎ, Maria Chudnovsky, Matthias Beck, Matthias Beck, Matthias Beck, Matthias Beck, Mireille Bousquet-Mélou, Mordechai Katzman, Neil L. White, P. McMullen, R.P. Stanley, RICHARD P. STANLEY, Richard P. Stanley, S. Payne, T. Hibi, T. Hibi, Tadahito Harima, Takayuki Hibi, Takayuki Hibi, Thomas Lam, V.V. Batyrev, Winfried Bruns   +45 more
core   +1 more source

Metal‐Coordination Specificity and Structural Dynamics of C. elegans Metallothionein I: Insights From 3D Modeling and MD Simulations

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Metallothioneins (MTLs) are small, cysteine‐rich proteins known for their ability to bind metal ions and exhibit flexible, disordered structures. The structural and functional characteristics of metallothionein I (MTL‐1) from Caenorhabditis elegans were investigated, focusing on its behavior in both metal free (MTL‐1 Apo) and metal‐bond states
Nilvea Ramalho de Oliveira, Andrei Santos Siqueira, Paulo Sérgio Alves Bueno, Evonnildo Costa Gonçalves, Juliano Zanette   +4 more
wiley   +1 more source