Results 41 to 50 of about 87,805 (279)
Mapping Charge Interactions in Intrinsically Disordered Proteins
Advanced Science, EarlyView.This study presents analytical models to predict intrachain distances in intrinsically disordered proteins (IDPs), accounting for charge patterning, salt concentration, and electrostatic effects. Validated against single‐molecule FRET data, a minimal‐parameter polymer model is identified that captures key interactions and chain dimensions. These models
Michael Phillips +14 more
wiley +1 more source
Brazilian Constitutional Amendment Proposal 187 of 2019
Mises, 2023 O objetivo deste artigo é discutir a Proposta de Emenda Constitucional 187 de 2019 (PEC 187/2019), apresentada pelo Ministério da Economia como parte de uma Agenda de Reforma Econômica para melhorar a gestão orçamentária e financeira das Entidades ...
Mathias Tessmann +1 more
doaj +1 more source
Advanced Science, EarlyView.This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen +8 more
wiley +1 more source
Prediction of Pharmacokinetics of IDP-73152 in Humans Using Physiologically-Based Pharmacokinetics
Pharmaceutics, 2022 IDP-73152, a novel peptide deformylase inhibitor with an antibacterial effect against Gram-positive bacteria, is in phase I development. The objective of this study was to develop a physiologically-based pharmacokinetic model (PBPK) for IDP-73152 in ...
Myongjae Lee +4 more
doaj +1 more source
Advanced Science, EarlyView.This study uncovers two overlooked bottlenecks in cryogenic laser cooling of solids: symmetry‐driven fluorescence trapping and water vapor condensation. We demonstrate that breaking sample symmetry enhances fluorescence escape, while condensation dominates parasitic heating below 135 K.
Biao Zhong +5 more
wiley +1 more source
Advanced Science, EarlyView.Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély +5 more
wiley +1 more source
ECONOMIC ANALYSIS OF LITIGATION: BASIC ASSUMPTIONS AND BRAZIL’S 2015 CIVIL PROCEDURE CODE
Revista Eletrônica de Direito Processual, 2019 In order to turn litigation more efficient in Brazil, by bringing it closer to socially desirable levels, the Civil Procedure Code of 2015 envisaged or improved four important procedural institutes: conciliation and mediation; precedents system; fines ...
Victor Guedes Trigueiro +1 more
doaj +1 more source
Britishness and Muslim-ness: differentiation, demarcation and discrimination in political discourse [PDF]
, 2015 The Britishness agenda found in political speeches, reporting and opinion editorials is here posited as a form of ‘new racism’, as it emphasises the difference between ‘them’, Muslims, and ‘us’, non-Muslim Britons, and uses that difference as a defining ...
Allen, Chris
core +1 more source
Artificial Intelligence for Bone: Theory, Methods, and Applications
Advanced Intelligent Discovery, EarlyView.Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan +3 more
wiley +1 more source
Revista do Direito PúblicoVisa o presente artigo analisar as execuções fiscais em relação a alguns municípios que compõem a região do Alto Tietê, notadamente as cidades de Itaquaquecetuba, Mogi das Cruzes e Suzano.
Fábio Camargo +1 more
doaj +1 more source