Results 71 to 80 of about 99,503 (309)

Sequence Versus Composition: What Prescribes IDP Biophysical Properties?

Entropy, 2019
Intrinsically disordered proteins (IDPs) represent a distinct class of proteins and are distinguished from globular proteins by conformational plasticity, high evolvability and a broad functional repertoire.
J. Vymětal, J. Vondrášek, K. Hlouchová   +2 more
semanticscholar   +1 more source

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

Advanced Healthcare Materials, EarlyView.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo, Daniel Lozano, Antonio J. Salinas, María Vallet‐Regí   +3 more
wiley   +1 more source

Intrinsically Disordered Protein‐Inspired Nanovector‐Based Coacervates for the Direct Cytosolic Transport of Biomacromolecules

Advanced Materials, EarlyView.
Intrinsically disordered protein‐inspired nanovectors (IDP‐NVs) form stable nanocoacervates (NCs) with diverse biomacromolecules. In situ conformational changes confer stability and adaptability to NCs under dynamically changing physiological conditions.
Soyeong Jin, Hyemin Park, Seuk‐Min Ryu, Dagyeong Guk, Jaeeun Lee, Seongeon Jin, Changjoon Keum, Jinyoung Park, Myoung‐Hwan Park, Chaekyu Kim, Hojun Kim, Jaegeun Noh, Kwan Hyi Lee, Ja‐Hyoung Ryu, Youngdo Jeong   +14 more
wiley   +1 more source

IDP-ASE: haplotyping and quantifying allele-specific expression at the gene and gene isoform level by hybrid sequencing

Nucleic Acids Research, 2016
Allele-specific expression (ASE) is a fundamental problem in studying gene regulation and diploid transcriptome profiles, with two key challenges: (i) haplotyping and (ii) estimation of ASE at the gene isoform level.
Benjamin E. Deonovic, Yunhao Wang, Jason L. Weirather, Xiu-Jie Wang, K. Au   +4 more
semanticscholar   +1 more source

Structural Interface Engineering Unlocks Native‐Like Mechanics in Biomimetic Intervertebral Discs

Advanced Materials Interfaces, EarlyView.
Engineered interlamellar and radial fibrous interfaces enable biomimetic intervertebral disc constructs to replicate native mechanical behavior. Suture‐reinforced laminates enhance cohesion and shear strength, while radial fibers improve compressive resilience and stress redistribution.
Haim S. Mordechai, Javad Tavakoli, Sarit S. Sivan, Mirit Sharabi   +3 more
wiley   +1 more source

Genome‐Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes

Advanced Science, EarlyView.
This study explores genome‐wide by lifetime environment interactions on brain imaging phenotypes. Gene‐environment interactions explain more phenotypic variance than main effects, pinpoint regulatory variants, and reveal exposure‐specific biological pathways.
Sijia Wang, Meiyun Wang, Peng Zhang, Jingliang Cheng, Longjiang Zhang, Wenzhen Zhu, Shijun Qiu, Zuojun Geng, Guangbin Cui, Yongqiang Yu, Weihua Liao, Xi‐Nian Zuo, Hui Zhang, Bo Gao, Xiaojun Xu, Tong Han, Zhenwei Yao, Quan Zhang, Feng Liu, Qiang Xu, Jiayuan Xu, Jilian Fu, Nana Liu, Yuan Ji, Jie Tang, Lining Guo, Mengge Liu, Xiaoxiao Xiao, Xiaoxuan Liu, Wei Li, Caihong Wang, Wei Wei, Dapeng Shi, Su Lui, Zhihan Yan, Feng Chen, Jing Zhang, Wen Shen, Yanwei Miao, Dawei Wang, Jia‐Hong Gao, Yunjun Yang, Kai Xu, Junfang Xian, Bing Zhang, Xiaochu Zhang, Zhaoxiang Ye, Le Yu, Wen Qin, Meng Liang, Chunshui Yu, the CHIMGEN Consortium   +51 more
wiley   +1 more source

Use of rivers' water, inadequate hygiene, and sanitation as exposure of internally displaced persons (IDPs) to urogenital schistosomiasis and soil-transmitted helminthiasis in Jalingo Local Government Area (LGA), Taraba State, Nigeria [PDF]

, 2022
Wama Emmanuel Binga, Robert Soumay Houmsou, Liatu Columbus Garba, E. U. Amuta, Kela Larit Santaya   +4 more
openalex   +1 more source

Peptide Electrostatic Modulation Directs Human Neural Cell Fate

Advanced Science, EarlyView.
This study explores the effect of charge on the bioactivity of peptide‐based supramolecular materials. The design of a peptide library with varying charges that self‐assemble into supramolecular fibers is presented, demonstrating how the surface charge of these fibers, used as artificial extracellular matrices, influences the fate of human neural ...
Laura Perez‐Chirinos, Xavier Barceló, M. Gabriella Chiariello, Irene Sanz, Amaia Iturrospe, Arantxa Arbe, J. Alberto Ortega, Siewert J. Marrink, Aitziber L. Cortajarena, Zaida Álvarez, Ivan R. Sasselli   +10 more
wiley   +1 more source

Brazilian Constitutional Amendment Proposal 187 of 2019

Mises, 2023
O objetivo deste artigo é discutir a Proposta de Emenda Constitucional 187 de 2019 (PEC 187/2019), apresentada pelo Ministério da Economia como parte de uma Agenda de Reforma Econômica para melhorar a gestão orçamentária e financeira das Entidades ...
Mathias Tessmann, Glauco Fonteles Oliveira E Silva   +1 more
doaj   +1 more source

Marginal Stability of the YB1 Cold‐Shock Domain in Cells Enables Binding of Multiple Nucleic Acids

Advanced Science, EarlyView.
This study suggests that the marginal stability of the YB1 Cold‐Shock Domain (CSDex) allows for a balance between multifunctionality and conformational changes under physiological conditions. This balance is driven by the dynamic equilibrium between the unfolded ensemble (UE) and the native ensemble (NE) of CSDex (PDB:6LMR).
Puja Shrestha, Sara S. Ribeiro, Janne Aurich, Christian Herrmann, Simon Ebbinghaus   +4 more
wiley   +1 more source