Results 221 to 230 of about 190,232 (322)

AI‐Powered Framework for Evaluating Drug Efficacy for Three‐Dimensional In Vitro Cancer Models in Robot‐Assisted Production

Advanced Robotics Research, EarlyView.
An AI‐powered, robot‐assisted framework automatically produces, images, and analyzes 3D tumor spheroids to evaluate drug efficacy. Integrated modules handle spheroid formation, live/dead staining, brightfield imaging, and automated image analysis, including spheroid segmentation, viability and metrics to assess the drug treatment efficacy. The workflow
Dalia Mahdy, Jesus Nieves, Lukas Königer, Matthias Peindl, Fabio Erhard, Marc Möllmann, Anke Klingner, Markus Münig, Bibin Babu, Thomas Schwarz, Marco Metzger, Gudrun Dandekar, Maximiliane Wußmann, Jan Hansmann   +13 more
wiley   +1 more source

Domain-substituted IGF2 tag modulates targeting of lentiviral gene therapy for Hunter syndrome. [PDF]

EMBO Mol Med
Catalano F, Stevic D, Zundo G, Huizer TF, Dammou Z, Vlaar EC, Katsavelis D, van den Bosch JC, van den Hout HJMP, Oussoren E, van der Ploeg AT, Ruijter GJG, Schaaf G, Pijnappel WWMP.   +13 more
europepmc   +1 more source

Bacteria and Fungi Synergistically Reprogram Flavonoid Metabolites in the Pericarp of Citrus Reticulata 'Chachi' During Storage

Advanced Science, EarlyView.
The authors employed widely targeted metabolomics, microbial amplicon sequencing, and fermentation assays to investigate the microbiome 's influence on PCRC 's (pericarp of Citrus reticulata ' Chachi ') flavonoid profile over 0–19 years of storage. Based on the correlation analysis, solid‐state and liquid‐state fermentation, and catalytic activity ...
Jianmu Su, Sisheng Zhang, Lidi Liang, Haiyi Bai, Mei Bai, Hanjun He, Yayu Wang, Huan Liu, Xiangxiu Liang, Yu Sun, Hong Wu   +10 more
wiley   +1 more source

A transcriptome dataset from porcine stem cells with differing adipogenic capacity. [PDF]

Data Brief
Thrower T, Riley SE, Grabowski K, Esteves CL, Donadeu FX.   +4 more
europepmc   +1 more source

Unique placeholder IDs for each gene, transcript and exon model in the "UMD CASPUR WD 2.0" annotation of the water buffalo (Bubalis bubalis) genome assembly

, 2018
Stephen J. Bush
openalex   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

JoGo 1.0: the ACTG hierarchical nomenclature and database covering 4.7 million haplotypes across 19,194 human genes. [PDF]

Nucleic Acids Res
Nagasaki M, Katayama T, Moriya Y, Sekiya Y, Kawashima S, Teraoka R, Machida S, Matsubara T, Hashimoto H, Asakura A, Nagano A, Yamashita R, Takada T, Mitsuhashi N, Kamada M, Ohkawa Y, Tokunaga K, Kawai Y, Variant Information Standardization Collegium .   +18 more
europepmc   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Quantitative proteomics of infected macrophages reveals novel Leishmania virulence factors. [PDF]

PLoS Pathog
Hagedorn N, Fradera-Sola A, Mitnacht M, Gold T, Schleicher U, Butter F, Janzen CJ.   +6 more
europepmc   +1 more source

Gene IDs of kinetoplastid genes in the 4 BUSCO conserved protein clusters with a single SRBH.

Juan Manuel Trinidad-Barnech (21156521), José Sotelo-Silveira (3457943), Darío Fernández Do Porto (12022091), Pablo Smircich (158558)   +3 more
openalex   +1 more source