Results 251 to 260 of about 190,979 (293)

Id gene expression during development and molecular cloning of the human Id-1 gene

Molecular Brain Research, 1995
Id genes encode helix-loop-helix proteins that inhibit transcription by forming inactive heterodimers with basic helix-loop-helix (bHLH) proteins. bHLH proteins normally form either homodimers or heterodimers with other bHLH proteins and bind to a DNA sequence element activating transcription. Id-containing heterodimers are inactive because Id proteins
W, Zhu, J, Dahmen, A, Bulfone, M, Rigolet, M C, Hernandez, W L, Kuo, L, Puelles, J L, Rubenstein, M A, Israel   +8 more
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X-Linked ASDs and ID Gene Mutations

2016
Intellectual disability (ID) defines a group of disorders that cause impairment in intellectual performance. Autism spectrum disorders (ASDs) cause deficits in communication and social skills in addition to repetitive and stereotyped behaviors. We focus our attention on IDs and ASDs caused by mutations within the X chromosome on genes that exert their ...
Moretto E, Passafaro M, Bassani S
openaire   +3 more sources

Id genes and proteins as promising targets in cancer therapy

Trends in Molecular Medicine, 2004
Since the identification of Id proteins more than a decade ago, much work has demonstrated their regulatory roles in development, cell fate and lineage determination, proliferation, differentiation, angiogenesis, invasion and migration. Recent studies reveal not only that Id protein expression is significantly correlated both with cancer progression ...
Sylvia, Fong, Robert J, Debs, Pierre-Yves, Desprez   +2 more
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Polymorphism of the murine inhibitor of differentiation-controlling gene, Id

Gene, 1995
The structure of Id was examined by Southern analysis in inbred mouse lines which included five subspecies of Mus musculus. No variation was detected within this species. The species Mus cookii shares the same form found in mice of M. musculus derivation, indicative of a long evolutionary history and a common origin.
S A, Marlow, P H, Kay, J M, Papadimitriou   +2 more
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Gene symbol: IDS. Disease: mucopolysaccharidosis type II (Hunter syndrome).

Human genetics, 2006
We report here the first exonic splicing mutation in a 8-year old intermediate Hunter patient. Genomic DNA sequencing identified a G to C transversion involving the last nucleotide of IDS exon VI (ExVI 1003G>C). The mutation leads to the disappearance of the normal exon VI/intron 6 splice donor site, resulting in the skipping of a 28 bp fragment of ...
Villani GR, Pontarelli G, Kotroni G, PARENTI, GIANCARLO, Sibilio M, ANDRIA, GENEROSO, DI NATALE, PAOLA   +6 more
openaire   +4 more sources

Nucleos(t)ide analogues causes HBV S gene mutations and carcinogenesis

Hepatobiliary & Pancreatic Diseases International, 2016
The long-term use of nucleos(t)ide analogues causes drug resistance and mutations in the HBV reverse transcriptase (RT) region of the polymerase gene. The RT region overlaps the HBV surface gene (S gene) and therefore, the mutations in the RT region simultaneously modify S gene sequence.
Meng-Lan, Wang, Hong, Tang
openaire   +2 more sources

Structural organisation and chromosomal mapping of the human Id-3 gene

Gene, 1994
The helix-loop-helix (HLH) family of transcription factors plays a central role in the regulation of cell growth, differentiation and tumourigenesis. Members of the Id (inhibitor of DNA binding) class of these nuclear proteins are able to heterodimerise with and thereby antagonise the functions of other transcription factors of this family.
R W, Deed, T, Hirose, E L, Mitchell, M F, Santibanez-Koref, J D, Norton   +4 more
openaire   +2 more sources

Identifier (ID) elements are not preferentially located to brain-specific genes: High ID element representation in other tissue-specific- and housekeeping genes of the rat

Gene, 2014
BC1 is a short non-coding RNA from rodents, which is transcribed by RNA pol III. Its RNA is highly abundant in the brain, where it exerts a post-transcriptional regulatory role in dendrites. Upon transcription, retroposition and insertion, BC1 gives rise to a subclass of short interspersed repetitive sequences (SINEs) named identifier (ID) elements ...
Andrés, Goldman, Carlos A, Capoano, Evangelina, González-López, Adriana, Geisinger   +3 more
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Regulation of Id Gene Expression during Embryonic Stem Cell-Derived Hematopoietic Differentiation

Biochemical and Biophysical Research Communications, 2000
To elucidate the role of helix-loop-helix (HLH) Id proteins in hematopoietic differentiation, we used a model of embryonic stem (ES) cell differentiation in vitro which gives access not only to hematopoietic myeloid progenitor cells but also to the more primitive blast colony-forming cell (BL-CFC), the in vitro equivalent of the hemangioblast that ...
M M, Nogueira, M T, Mitjavila-Garcia, F, Le Pesteur, M D, Filippi, W, Vainchenker, A, Dubart Kupperschmitt, F, Sainteny   +6 more
openaire   +2 more sources