Results 41 to 50 of about 190,232 (322)
Large-scale event extraction from literature with multi-level gene normalization [PDF]
, 2013 Text mining for the life sciences aims to aid database curation, knowledge summarization and information retrieval through the automated processing of biomedical texts.
Ananiadou, Sophia +10 more
core +3 more sources
ID gene activity during Xenopus embryogenesis
Mechanisms of Development, 1995 The activity of bHLH transcription factors that are involved in cell determination and differentiation is inhibited by Ids, HLH proteins lacking the basic amino acid sequence element. In order to determine the role of Id during development, we have isolated and characterized the Id genes expressed in Xenopus embryos.
Zhang, Hong +4 more
openaire +2 more sources
Detailed pedigree analyses and prenatal diagnosis for a family with mucopolysaccharidosis type II
BMC Medical Genomics, 2021 Background Mucopolysaccharidosis type II (MPS II) is an X-linked multisystem disorder caused by mutations in the gene encoding iduronate 2-sulfatase (IDS).
Chuan Zhang +13 more
doaj +1 more source
Frontiers in Genetics, 2023 Background: Mucopolysaccharidosis Type II (MPS II) is a rare, progressive and ultimately fatal X-linked lysosomal storage disorder caused by mutations in the iduronate-2-sulfatase (IDS) gene.
Zhenjie Zhang +7 more
doaj +1 more source
Brain‐targeted stem cell gene therapy corrects mucopolysaccharidosis type II via multiple mechanisms
EMBO Molecular Medicine, 2018 The pediatric lysosomal storage disorder mucopolysaccharidosis type II is caused by mutations in IDS, resulting in accumulation of heparan and dermatan sulfate, causing severe neurodegeneration, skeletal disease, and cardiorespiratory disease.
Hélène FE Gleitz +8 more
doaj +1 more source
Do peers see more in a paper than its authors? [PDF]
, 2012 Recent years have shown a gradual shift in the content of biomedical publications that is freely accessible, from titles and abstracts to full text. This has enabled new forms of automatic text analysis and has given rise to some interesting questions ...
Divoli, Anna +2 more
core +3 more sources
The Plant Ontology facilitates comparisons of plant development stages across species [PDF]
, 2019 The Plant Ontology (PO) is a community resource consisting of standardized terms, definitions, and logical relations describing plant structures and development stages, augmented by a large database of annotations from genomic and phenomic studies.
Cooper, Laurel +7 more
core +2 more sources
DNA methylation profiling of primary neuroblastoma tumors using methyl-CpG-binding domain sequencing [PDF]
, 2016 Comprehensive genome-wide DNA methylation studies in neuroblastoma (NB), a childhood tumor that originates from precursor cells of the sympathetic nervous system, are scarce. Recently, we profiled the DNA methylome of 102 well-annotated primary NB tumors
Decock, Anneleen +4 more
core +1 more source
MetaboTools: A comprehensive toolbox for analysis of genome-scale metabolic models [PDF]
, 2016 Metabolomic data sets provide a direct read-out of cellular phenotypes and are increasingly generated to study biological questions. Our previous work revealed the potential of analyzing extracellular metabolomic data in the context of the metabolic ...
Aurich, Maike K. +2 more
core +3 more sources
ID genes mediate tumor reinitiation during breast cancer lung metastasis [PDF]
Proceedings of the National Academy of Sciences, 2007 The establishment of distant metastases depends on the capacity of small numbers of cancer cells to regenerate a tumor after entering a target tissue. The mechanisms that confer this capacity remain to be defined. Here we identify a role for the transcriptional inhibitors of differentiation Id1 and Id3 as selective mediators of lung ...
Gupta G. P. +9 more
openaire +3 more sources