Results 51 to 60 of about 2,908,134 (284)
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
, 2021 As an organisation that pursues and enables collaboration in constructing and sharing knowledge for development, IDS is committed to making research knowledge freely available, accessible, re-usable and relevant to those who can bring about progressive ...
Institute of Development Studies (IDS) (19282513)
core +1 more source
, 2017 This is a brochure to promote IDS' Masters courses in international development (http://www.ids.ac.uk/study)
IDS (19281550)
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Molecular Genetics and Metabolism Reports, 2020 We previously showed that the genotype-phenotype correlation in MPS II is well-conserved in Japan (Kosuga et al., 2016). Almost all of our patients with attenuated MPS II have missense variants, which is expected to result in residual activity of ...
Yasuyuki Fukuhara +9 more
doaj +1 more source
miRMut: Annotation of mutations in miRNA genes from human whole-exome or whole-genome sequencing
STAR Protocols, 2022 Summary: Here, we present the miRMut protocol to annotate mutations found in miRNA genes based on whole-exome sequencing (WES) or whole-genome sequencing (WGS) results.
Martyna O. Urbanek-Trzeciak +2 more
doaj +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
IDS Postgraduate Prospectus 2020
, 2019 The Institute of Development Studies (IDS) is a global research and learning organisation for equitable and sustainable change. In partnership with the University of Sussex, IDS is ranked first in the world for development studies by the QS University ...
IDS (19281550)
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Localization of the Usher syndrome type ID gene (Ush1D) to chromosome 10 [PDF]
Human Molecular Genetics, 1996 The Usher syndromes (USH) are a group of autosomal recessive diseases characterized by progressive pigmentary retinopathy and sensorineural hearing loss. Five USH genes have been mapped and at least one additional gene is known to exist. By homozygosity mapping in a consanguineous family, a sixth USH gene has been localized.
S, Wayne +7 more
openaire +2 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
CRISPR/Cas9 Epigenome Editing Potential for Rare Imprinting Diseases: A Review
Cells, 2020 Imprinting diseases (IDs) are rare congenital disorders caused by aberrant dosages of imprinted genes. Rare IDs are comprised by a group of several distinct disorders that share a great deal of homology in terms of genetic etiologies and symptoms ...
Linn Amanda Syding +3 more
doaj +1 more source