Results 51 to 60 of about 190,232 (322)
Stromal upregulation of lateral epithelial adhesions: gene expression analysis of signalling pathways in prostate epithelium [PDF]
, 2011 Background: Stromal signalling increases the lateral cell adhesions of prostate epithelial cells grown in 3D culture. The aim of this study was to use microarray analysis to identify significant epithelial signalling pathways and genes in this process ...
Chambers, Karen F. +6 more
core +4 more sources
Identification of the iduronate-2-sulfatase proteome in wild-type mouse brain
Heliyon, 2019 Iduronate-2-sulfatase (IDS) is a lysosomal enzyme involved in the metabolism of the glycosaminoglycans heparan (HS) and dermatan (DS) sulfate. Mutations on IDS gene produce mucopolysaccharidosis II (MPS II), characterized by the lysosomal accumulation of
Carolina Cardona +8 more
doaj +1 more source
PLoS ONE, 2010 The insulin-degrading enzyme gene (IDE) is a strong functional and positional candidate for late onset Alzheimer's disease (LOAD).We examined conserved regions of IDE and its 10 kb flanks in 269 AD cases and 252 controls thereby identifying 17 putative functional polymorphisms. These variants formed eleven haplotypes that were tagged with ten variants.
Minerva M Carrasquillo +45 more
openaire +11 more sources
Molecular Genetics and Metabolism Reports, 2023 Mucopolysaccharidosis II (MPS II) is an X-linked, recessive, inborn metabolic disorder caused by defects in iduronate-2-sulfatase (IDS). The age at onset, disease severity, and rate of progression vary significantly among patients.
Yusuke Hattori +8 more
doaj +1 more source
MEME-LaB : motif analysis in clusters [PDF]
, 2013 Genome-wide expression analysis can result in large numbers of clusters of co-expressed genes. While there are tools for ab initio discovery of transcription factor binding sites, most do not provide a quick and easy way to study large numbers of ...
Bailey +11 more
core +1 more source
Two Independent Pathways for Self-Recognition in Proteus Mirabilis Are Linked by Type VI-Dependent Export [PDF]
, 2013 Swarming colonies of the bacterium Proteus mirabilis are capable of self-recognition and territorial behavior. Swarms of independent P. mirabilis isolates can recognize each other as foreign and establish a visible boundary where they meet; in contrast ...
Cardarelli, L. +4 more
core +2 more sources
Motor Nucleus of the Trigeminal Nerve [PDF]
, 2008 This report contains a summary of expression patterns for genes that are enriched in the motor nucleus of the trigeminal nerve (V) of the pons. All data is derived from the Allen Brain Atlas (ABA) in situ hybridization mouse project. The structure's
Allen Institute for Brain Science +3 more
core +2 more sources
Sequence of the Human Iduronate 2-Sulfatase (IDS) Gene
Genomics, 1993 Deficiency of the lysosomal enzyme iduronate-2-sulfatase (IDS; EC 3.1.6.13) results in the storage of the glycosaminoglycans heparan sulfate and dermatan sulfate, which leads to the lysosomal storage disorder mucopolysaccharidosis type II. Three overlapping genomic clones derived from an X-chromosome-specific library containing the entire IDS gene were
P J, Wilson +3 more
openaire +2 more sources
A case report of a patient with mucopolysaccharidosis type II
Revista Médica del Hospital General de México, 2017 Mucopolysaccharidosis type II (MPS II) or Hunter syndrome is an inborn error of metabolism due to lysosomal accumulation, with a recessive inheritance pattern linked to the X chromosome.
M.R. Rivera Vega +3 more
doaj +1 more source
Multiple tests of association with biological annotation metadata
, 2008 We propose a general and formal statistical framework for multiple tests of association between known fixed features of a genome and unknown parameters of the distribution of variable features of this genome in a population of interest.
Mark J. Van Der Laan +4 more
core +2 more sources