Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response. [PDF]
PLoS Pathogens, 2016 The human cytomegalovirus (hCMV) major immediate-early 1 protein (IE1) is best known for activating transcription to facilitate viral replication. Here we present transcriptome data indicating that IE1 is as significant a repressor as it is an activator ...
Thomas Harwardt +8 more
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Protective CD8+ T-cell responses to cytomegalovirus driven by rAAV/GFP/IE1 loading of dendritic cells [PDF]
Journal of Translational Medicine, 2008 Background Recent studies demonstrate that recombinant adeno-associated virus (rAAV)-based antigen loading of dendritic cells (DCs) generates in vitro, significant and rapid cytotoxic T-lymphocyte (CTL) responses against viral antigens.
Dalle-Donne Isabella +12 more
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Brain-specific expression of cytomegalovirus immediate early protein 1 disrupts neurodevelopment in mice by inducing neuroinflammation and altering astrocytic metabolism [PDF]
Virology JournalCongenital human cytomegalovirus (HCMV) infection is the leading cause of neurodevelopmental disorders in children, including nongenetic sensorineural hearing loss. Previous studies have shown that HCMV immediate early 1 (IE1) protein, also known as IE72,
Meng Yu +13 more
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A Baculovirus immediate-early gene, ie1, promoter drives efficient expression of a transgene in both Drosophila melanogaster and Bombyx mori. [PDF]
PLoS ONE, 2012 Many promoters have been used to drive expression of heterologous transgenes in insects. One major obstacle in the study of non-model insects is the dearth of useful promoters for analysis of gene function.
Mika Masumoto +4 more
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Complete cross strain protection against congenital cytomegalovirus infection requires a vaccine encoding key antibody (gB) and T-cell (immediate early 1 protein) viral antigens [PDF]
Frontiers in ImmunologyBackgroundCytomegalovirus is a leading cause of congenital disease, and multiple strains enable congenital CMV (cCMV) from both primary and non-primary infections. Therefore, a cross-strain protective cCMV vaccine is a high priority.
K. Yeon Choi +3 more
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PLoS ONE, 2014 Human cytomegalovirus (HCMV) is an important human pathogen. It is a leading cause of congenital infection and a leading infectious threat to recipients of solid organ transplants as well as of allogeneic hematopoietic cell transplants.
Peter Braendstrup +11 more
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Improving the production of baculovirus expression vector by overexpression of IE0/IE1 through tandem promoter. [PDF]
PLoS ONEThe baculovirus expression vector system, known for its protein production in insect cells and has been criticized for its relatively low expression capacity.
Sijun He +5 more
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PLoS Pathogens, 2021 Flap endonuclease 1 (FEN1) is a member of the family of structure-specific endonucleases implicated in regulation of DNA damage response and DNA replication. So far, knowledge on the role of FEN1 during viral infections is limited.
Eva-Maria Schilling +3 more
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Design optimization and real-time implementation of an LSPMSM for efficiency enhancement [PDF]
Scientific ReportsThis study presents the design optimization and experimental validation of a Line-Start Permanent Magnet Synchronous Motor (LSPMSM) aimed at achieving IE4 efficiency class. An IE1 class induction motor (IM) was used as a reference.
Cemil Ocak +5 more
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Hijacking of host Src-PI3K-Akt signaling by WSSV IE1 protein suppresses apoptotic and autophagic defenses to facilitate viral proliferation. [PDF]
J VirolLu K +6 more
europepmc +2 more sources