Results 1 to 10 of about 205,529 (308)

Control of human cytomegalovirus replication by liver resident natural killer cells

Nature Communications, 2023
Natural killer cells play important roles in the immune response to human cytomegalovirus infection. Here the authors implicate donor-derived liver resident natural killer cells in the control of human cytomegalovirus infection by analysis of perfusates ...
Calum Forrest, Thomas J. G. Chase, Antonia O. Cuff, Dionas Maroulis, Reza Motallebzadeh, Amir Gander, Brian Davidson, Paul Griffiths, Victoria Male, Matthew Reeves   +9 more
doaj   +1 more source

Presentation of an Immunodominant Immediate-Early CD8+ T Cell Epitope Resists Human Cytomegalovirus Immunoevasion. [PDF]

, 2013
Control of human cytomegalovirus (HCMV) depends on CD8+ T cell responses that are shaped by an individual's repertoire of MHC molecules. MHC class I presentation is modulated by a set of HCMV-encoded proteins.
Ameres, Stefanie, Busch, Dirk H., Mautner, Josef, Moosmann, Andreas, Neuenhahn, Michael, Plachter, Bodo, Schlott, Fabian   +6 more
core   +10 more sources

FREQUENCY OF HUMAN CYTOMEGALOVIRUS AND HUMAN HERPESVIRUS-1 ANTIGENS IN PRODUCT OF CONCEPTUS TISSUES OF PREGNANT WOMEN WITH SPONTANEOUS ABORTION

The Iraqi Journal of Medical Sciences, 2017
Background: Viral infections in pregnancy are major causes of maternal and fetal morbidity and mortality. Infections develop in the neonate transplacentally, perinatally or postnatally.
Areej A. Hussein, Sawsan T. Salman, Basim M. Khashman   +2 more
doaj   +6 more sources

Human cytomegalovirus-specific CD4+ and CD8+ T-cell reconstitution in adult allogeneic hematopoietic stem cell transplant recipients and immune control of viral infection

Haematologica, 2008
Background Human cytomegalovirus infection is the most frequent viral complication in patients undergoing hematopoietic stem cell transplantation.
Daniele Lilleri, Chiara Fornara, Antonella Chiesa, Daniela Caldera, Emilio Paolo Alessandrino, Giuseppe Gerna   +5 more
doaj   +1 more source

High-Risk Oncogenic Human Cytomegalovirus

Viruses, 2022
Human cytomegalovirus (HCMV) is a herpesvirus that infects between 40% and 95% of the population worldwide, usually without symptoms. The host immune response keeps the virus in a latent stage, although HCMV can reactivate in an inflammatory context ...
Georges Herbein
doaj   +1 more source

Significance of herpesvirus immediate early gene expression in cellular immunity to cytomegalovirus infection [PDF]

, 1984
Interstitial pneumonia linked with reactivation of latent human cytomegalovirus due to iatrogenic immunosuppression can be a serious complication of bone marrow transplantation therapy of aplastic anaemia and acute leukaemia1.
A Ebeling, AB Rickinson, ARM Townsend, ARM Townsend, B Roizman, BT Rouse, C Taswell, deSt Fazekas, DR Mayo, G Berke, GM Keil, GV Quinnan, JB Hudson, JD Meyers, JD Shanley, JE Grundy, JK Chantler, JR Bennink, JR Marks, LK Borysiewicz, LR Gooding, M Ho, Matthias J. Reddehase, MC Jordan, MF Stinski, MJ Bevan, MJ Imperiale, MJ Reddehase, MJ Reddehase, MR Green, PG Spear, RJ Watson, RM Stenberg, RW Honess, SS Tevethia, UH Koszinowski, Ulrich H. Koszinowski   +36 more
core   +1 more source

Simultaneous monitoring of CMV and human herpesvirus 6 infections and diseases in liver transplant patients: one-year follow-up

Clinics, 2011
OBJECTIVE: The aim of this study was to simultaneously monitoring cytomegalovirus and human herpesvirus 6 active infections using nested-polymerase chain reaction and, together with clinical findings, follow the clinical status of patients undergoing ...
Fernanda Aparecida Costa, Marcelo Naoki Soki, Paula Durante Andrade, Sandra Helena Alves Bonon, Ronaldo Luis Thomasini, Ana Maria Sampaio, Marcelo de Carvalho Ramos, Claudio Lúcio Rossi, Teresa Cristina Cavalcanti, Ilka de Fatima Boin, Marília Leonard, Luiz Sérgio Leonard, Raquel Bello Stucchi, Sandra Cecília Botelho Costa   +13 more
doaj   +1 more source

Using the nonhuman primate model of HCMV to guide vaccine development. [PDF]

, 2014
The natural history of human cytomegalovirus (HCMV) is inextricably associated with mucosal surfaces. The vast preponderance of primary infections occur following mucosal exposure to infectious virions, and the high seroprevalence of HCMV throughout the ...
Barry, Peter A, Deere, Jesse D
core   +3 more sources

Systematic microRNA analysis identifies ATP6V0C as an essential host factor for human cytomegalovirus replication.

PLoS Pathogens, 2013
Recent advances in microRNA target identification have greatly increased the number of putative targets of viral microRNAs. However, it is still unclear whether all targets identified are biologically relevant.
Jon Pavelin, Natalie Reynolds, Stephen Chiweshe, Guanming Wu, Rebecca Tiribassi, Finn Grey   +5 more
doaj   +1 more source

A fully human neutralizing monoclonal antibody targeting a highly conserved epitope of the human cytomegalovirus glycoprotein B.

PLoS ONE, 2023
Human cytomegalovirus causes severe diseases in children (by congenital infection) and immunocompromised patients. Treatment with antiviral agents, such as ganciclovir, is limited by their toxicity.
Miwa Okamoto, Rika Kurino, Ryu Miura, Kenzo Takada   +3 more
doaj   +1 more source