Results 41 to 50 of about 9,097,628 (294)

Preservation of Anti-cytomegalovirus Activity in Human Milk Following High-Pressure Processing Compared to Holder Pasteurization

Frontiers in Nutrition, 2022
Pasteurized donor human milk is recommended for hospitalized preterm infants when mother’s own milk is unavailable. Our aim was to compare the antiviral activity of human milk processed by Holder pasteurization (HoP) or high-pressure processing (HPP ...
Akash Kothari, Akash Kothari, Michael A. Pitino, Michael A. Pitino, Sharon Unger, Sharon Unger, Sharon Unger, Véronique Perreault, Alain Doyen, Yves Pouliot, Allison J. McGeer, Allison J. McGeer, Allison J. McGeer, Debbie Stone, Deborah L. O’Connor, Deborah L. O’Connor, Deborah L. O’Connor, Deborah L. O’Connor   +17 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Analysis of memory-like natural killer cells in human cytomegalovirus-infected children undergoing αβ+T and B cell-depleted hematopoietic stem cell transplantation for hematological malignancies

Haematologica, 2016
We analyzed the impact of human cytomegalovirus infection on the development of natural killer cells in 27 pediatric patients affected by hematological malignancies, who had received a HLA-haploidentical hematopoietic stem cell transplantation, depleted ...
Letizia Muccio, Alice Bertaina, Michela Falco, Daniela Pende, Raffaella Meazza, Miguel Lopez-Botet, Lorenzo Moretta, Franco Locatelli, Alessandro Moretta, Mariella Della Chiesa   +9 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

In vivo application of recombinant interleukin 2 in the immunotherapy of established cytomegalovirus infection [PDF]

, 1987
We have shown in a murine model system for cytomegalovirus (CMV) disease in the immunocompromised host that in vivo application of recombinant human IL-2 (rhIL-2) can enhance the antiviral effect of a limited number of CD8+T lymphocytes, not only in ...
Reddehase, Matthias J., W Mutter, Koszinowski, Ulrich H., Wolfgang Mutter, J. Reddehase, M J Reddehase, U H Koszinowski, Koszinowski, Ulrich, Mutter, Wolfgang, Ulrich H. Koszinowski   +9 more
core   +2 more sources

Cytomegalovirus colitis in a patient with HIV infection shortly after initiation of antiretroviral therapy

IDCases, 2019
We present a case of a man infected with human immunodeficiency virus (HIV) and who was diagnosed with Cytomegalovirus (CMV) colitis shortly after initiation of antiretroiviral therapy (ART).
Shinji Yoshida, Nobuaki Mori, Miwako Honda   +2 more
doaj   +1 more source

The Human Cytomegalovirus Latency-Associated Gene Product Latency Unique Natural Antigen Regulates Latent Gene Expression

Viruses, 2023
Human cytomegalovirus (HCMV) infection can lead to either lytic or latent infection, which is dependent on the regulation of the viral major immediate early promoter (MIEP).
Emma Poole, Jonathan Lau, Ian Groves, Kate Roche, Eain Murphy, Maria Carlan da Silva, Matthew Reeves, John Sinclair   +7 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Human cytomegalovirus (HCMV) replication dynamics in HCMV-naive and -experienced immunocompromised hosts [PDF]

, 2002
Human cytomegalovirus (HCMV) can infect both HCMV-naive and -experienced transplant patients. In this study, the growth rate of HCMV in HCMV-naive hosts (1.82 units/day; 95% confidence interval [CI], 1.44-2.56 units/day) was shown to be significantly ...
Emery, VC, Griffiths, PD, Hassan-Walker, AF, Burroughs, AK   +3 more
core  

Resistance and chemosensitivity restoration in human cytomegalovirus-infected tumor cells to doxorubicin through combined treatment with aqueous fullerene dC₆₀

Вопросы вирусологии
Introduction. Human cytomegalovirus infection can induce tumor cell resistance to chemotherapeutic agents through modulation of apoptotic pathways. In the search for alternative approaches to overcome virus-associated drug resistance, the application of ...
Yana Yu. Chernoryzh, Kirill I. Yurlov, Tatyana V. Grebennikova, Sergey M. Andreev, Ekaterina I. Lesnova, Ruslan A. Simonov, Natalia E. Fedorova, Alla A. Kushch   +7 more
doaj   +1 more source