Results 61 to 70 of about 9,097,628 (294)

Towards a Prophylactic Vaccine for the Prevention of HCMV Infection

Vaccines, 2021
Human cytomegalovirus (HCMV) or human herpesvirus 5, is a ubiquitous human herpesvirus, which can cause severe disease in immunocompromised patients (AIDS patients and solid organ transplant or hematopoietic stem cell transplant recipients) [...]
Gaëtan Ligat, Sophie Alain, Sébastien Hantz   +2 more
doaj   +1 more source

CNTN2 Deficiency Disrupts Ascending Auditory Neuroglial Interactions and Redox Homeostasis in Neural Presbycusis

Advanced Science, EarlyView.
. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen, Jingyi Zhu, Sihan Huang, Beibei Xu, Maoli Duan, Jingrong Lv, Jiarui Chen, Jun Yang, Shule Hou   +8 more
wiley   +1 more source

Antibody Cross-Reactivity between Porcine Cytomegalovirus (PCMV) and Human Herpesvirus-6 (HHV-6)

Viruses, 2017
Porcine cytomegalovirus (PCMV) infection is widely prevalent among pigs, and PCMV is one of the viruses which may be transmitted during xenotransplantation using pig cells, tissues, or organs. While human cytomegalovirus (HCMV) is a major risk factor for
Uwe Fiebig, Angela Holzer, Daniel Ivanusic, Elena Plotzki, Hartmut Hengel, Frank Neipel, Joachim Denner   +6 more
doaj   +1 more source

Understanding HCMV Latency Using Unbiased Proteomic Analyses

Pathogens, 2020
Human cytomegalovirus (HCMV) establishes either a latent (non-productive) or lytic (productive) infection depending upon cell type, cytokine milieu and the differentiation status of the infected cell.
Emma Poole, John Sinclair
doaj   +1 more source

Pre-Transplant Platelet Refractoriness and Alternative Donors Are Associated With Cytomegalovirus Retinitis in Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundCytomegalovirus retinitis is a severe, vision-threatening opportunistic infection in an immunodeficient population. Reports on cytomegalovirus retinitis in hematopoietic stem cell transplant recipients due to severe aplastic anemia have been ...
Yuehong Zhang, Yuqin Liang, Xu Zhang, Shunqing Wang, Jinpeng Cao, Jinpeng Cao, Zongyin Gao, Ling Li, Wenjian Mo   +8 more
doaj   +1 more source

Inhibition of Human Cytomegalovirus by Rifampin

Journal of General Virology, 1975
Replication of human cytomegalovirus (CMV) was inhibited by 50 mug/ml of rifampin. Nevertheless, a number of functions of CMV were still expressed in the presence of rifampin, including early cell rounding, and the development of immuno-fluorescent antigen, haemadsorption antigen, complement-fixing antigen and precipitin antigens.
T, Furukawa, S, Tanaka, S A, Plotkin
openaire   +2 more sources

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Cytomegalovirus microRNAs facilitate persistent virus infection in salivary glands. [PDF]

, 2010
Micro (mi)RNAs are small non-coding RNAs that regulate the expression of their targets' messenger RNAs through both translational inhibition and regulation of target RNA stability.
Marcinowski, Lisa, Lars Dölken, Astrid Krmpotic, Jonjic, S. (Stipan), Kothe, Sheila, Ruzsics, Zsolt, Tanguy Mélanie, Koszinowski, Ulrich H, Dölken Lars, Krmpotic Astrid, Zsolt Ruzsics, Ruzsics, Z. (Zsolt), Tuddenham, L. (Lee), Jonjic Stipan, Elefant, N. (Naama), Tanguy, Mélanie, Elefant Naama, Pfeffer, S. (Sebastien), Koszinowski, U. (Ulrich H), Marcinowski Lisa, Lisa Marcinowski, Elefant, Naama, Ulrich H Koszinowski, Tuddenham Lee, Altuvia, Yael, Koszinowski Ulrich H., Lee Tuddenham, Stipan Jonjic, Pfeffer Sébastien, Altuvia, Y. (Yael), Kothe Sheila, Sébastien Pfeffer, Tuddenham, Lee, Mélanie Tanguy, Margalit, Hanah, Ruzsics Zsolt, Margalit Hanah, Marcinowski, L. (Lisa), Krmpotic, A. (Astrid), Koszinowski, Ulrich H., Dölken, L. (Lars), Tanguy, M. (Mélanie), Krmpotic, Astrid, Sheila Kothe, Dölken, Lars, Ulrich H. Koszinowski, Yael Altuvia, Naama Elefant, Pfeffer, Sébastien, Kothe, S. (Sheila), Hanah Margalit, Altuvia Yael, Jonjic, Stipan, Margalit, H. (Hanah)   +53 more
core   +1 more source

Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH

Communications Biology, 2022
A panel of neutralizing human monoclonal antibodies targeting human cytomegalovirus offers a combination approach geared toward virus entry and replication to prevent viral dissemination.
Andrea J. Parsons, Sabrina I. Ophir, J. Andrew Duty, Thomas A. Kraus, Kathryn R. Stein, Thomas M. Moran, Domenico Tortorella   +6 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source