Results 51 to 60 of about 9,097,628 (294)

Modification of Specific Regions of the Human Cytomegalovirus Genome During in Vitro Passage

Canadian Journal of Infectious Diseases, 1990
Different regions of the human cytomegalovirus strain AD-169 DNA molecule were tested for stability using cloned Hind III fragments. Results indicate that insertion, deletion and/or rearrangement of nucleotide sequences occur at a relatively high ...
Claude Hamelin, Michel Dion
doaj   +1 more source

Clinical Characteristics and Concordance of Anti‐MDA5 Antibodies: A Multicenter Australian Study

Arthritis Care &Research, EarlyView.
Objective In Australia, anti‐MDA5 antibodies are exclusively tested by a line immunoblot assay (LIA). The clinical concordance of an LIA‐positive anti‐MDA5 result is unclear. We aimed to describe the clinical features and determine the clinical concordance of patients with anti‐MDA5 antibodies. Methods Electronic records of a multisite cohort (patients
Syed B. Ali, Thomas Khoo, Keeran Shivakumar, Adam Caroll, Lauren Hender, Dimitra Beroukas, Kim Griggs, Celina Jin, Theo De Malmanche, Jessica Day, Gabor Major, Vidya Limaye   +11 more
wiley   +1 more source

High ocular CMV copies and mismatched receipts may predict poor visual prognosis in CMV retinitis patients following allogeneic haematopoietic stem cell transplantation

BMC Ophthalmology, 2017
Background To summarize the clinical characteristics and potential factors affecting the visual outcomes in patients with cytomegalovirus retinitis following allogeneic haematopoietic stem cell transplantation (HSCT).
Yuehong Zhang, Xiangcai Ruan, Weizhong Yang, Ling Li, Zhuanhua Xian, Qiting Feng, Wenjian Mo   +6 more
doaj   +1 more source

Genetically Programmed Shape‐Morphing of Engineered Living Materials

Advanced Functional Materials, EarlyView.
Here, bacterial and mammalian engineered living materials (ELMs) are presented, in which living cells direct genetically programmed and enzymatically mediated shape‐morphing. The resulting deformation and shape‐recovery can be actuated in a genetically controlled manner by an ELM incorporating out‐of‐equilibrium counteracting biochemical reactions with
Jan Becker, Yuchen Liu, Miguel Baños, Rosanne Schmachtenberg, Mahmudul Hasan, Claudia Fink‐Straube, Luai R. Khoury, Wilfried Weber   +7 more
wiley   +1 more source

Characterization of the murine cytomegalovirus early transcription unit e1 that is induced by immediate-early proteins [PDF]

, 1990
The regulation of murine cytomegalovirus early (E) gene expression was studied in the cell line B25, which is stably transfected with the immediate-early ie1/ie3 gene complex.
Bühler, Bernhard, Koszinowski, Ulrich H., Keil, Günther M., Weiland, Frank   +3 more
core   +1 more source

MicroRNA-613 is downregulated in HCMV-positive glioblastoma and inhibits tumour progression by targeting arginase-2

Tumor Biology, 2017
Glioblastoma is the most common and malignant tumour that occurs primarily in nervous system and has a high morbidity. Research on glioblastoma has recently focused on human cytomegalovirus, belonging to the beta subfamily of Herpesviridae that plays ...
Yan Wang, Peng Zhao, Dongmeng Qian, Ming Hu, Li Zhang, Hailei Shi, Bin Wang   +6 more
doaj   +1 more source

Seroprevalence and Seroconversion Rates of Cytomegalovirus pp65 Antigen and Cord Blood Screening of Pregnant Women in Malatya, Turkey

Eurasian Journal of Medicine, 2019
Objective: The rates of seropositivity, seroconversion and fetal infection with human cytomegalovirus were analyzed in pregnant women and newborn cord blood in this study.
Keziban Dogan, Ayse Kafkasli, Cihan Kaya, Huseyin Cengiz   +3 more
doaj   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Selection of a highly invasive neuroblastoma cell population through long-term human cytomegalovirus infection. [PDF]

, 2012
The human cytomegalovirus (HCMV) is suspected to increase tumour malignancy by infection of cancer and/or stroma cells (oncomodulation). So far, oncomodulatory mechanisms have been attributed to the presence of HCMV and direct action of its gene products
Steinberger, D., Griffin, D.K., Breitling, Rainer, Barth, Susanne, Breitling, R., Cinatl, J., Doerr, Hans Wilhelm, Rothweiler, Florian, Steinberger, D, Hackmann, Karl, Rothweiler, F., Schröck, E, Schröck, Evelin, Hackmann, K., Michaelis, Martin, Cinatl, Jindrich, Bruch, J., Schröck, E., Doerr, H. W., Hackmann, K, Steinberger, Daniela, Barth, S., Cinatl Jr., J., Griffin, D. K., Michaelis, M., Bruch, James C., Cinatl, Jaroslav, Doerr, H.W., Bruch, Jochen, Griffin, Darren K., Breitling, R.; id_orcid   +30 more
core   +1 more source

Modeling congenital cytomegalovirus infection in human inner ear organoids

iScience
Summary: Congenital infection with human cytomegalovirus is a leading cause of congenital hearing loss. Investigating its effects is challenging due to the virus’s strict species specificity, limiting the relevance of animal models.
Lucia C.M. Grijpink, Wouter H. van der Valk, John C.M.J. de Groot, Heiko Locher, Ann C.T.M. Vossen   +4 more
doaj   +1 more source