Results 31 to 40 of about 134,051 (264)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Resistance and chemosensitivity restoration in human cytomegalovirus-infected tumor cells to doxorubicin through combined treatment with aqueous fullerene dC₆₀

Вопросы вирусологии
Introduction. Human cytomegalovirus infection can induce tumor cell resistance to chemotherapeutic agents through modulation of apoptotic pathways. In the search for alternative approaches to overcome virus-associated drug resistance, the application of ...
Yana Yu. Chernoryzh, Kirill I. Yurlov, Tatyana V. Grebennikova, Sergey M. Andreev, Ekaterina I. Lesnova, Ruslan A. Simonov, Natalia E. Fedorova, Alla A. Kushch   +7 more
doaj   +1 more source

High ocular CMV copies and mismatched receipts may predict poor visual prognosis in CMV retinitis patients following allogeneic haematopoietic stem cell transplantation

BMC Ophthalmology, 2017
Background To summarize the clinical characteristics and potential factors affecting the visual outcomes in patients with cytomegalovirus retinitis following allogeneic haematopoietic stem cell transplantation (HSCT).
Yuehong Zhang, Xiangcai Ruan, Weizhong Yang, Ling Li, Zhuanhua Xian, Qiting Feng, Wenjian Mo   +6 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

MicroRNA-613 is downregulated in HCMV-positive glioblastoma and inhibits tumour progression by targeting arginase-2

Tumor Biology, 2017
Glioblastoma is the most common and malignant tumour that occurs primarily in nervous system and has a high morbidity. Research on glioblastoma has recently focused on human cytomegalovirus, belonging to the beta subfamily of Herpesviridae that plays ...
Yan Wang, Peng Zhao, Dongmeng Qian, Ming Hu, Li Zhang, Hailei Shi, Bin Wang   +6 more
doaj   +1 more source

Seroprevalence and Seroconversion Rates of Cytomegalovirus pp65 Antigen and Cord Blood Screening of Pregnant Women in Malatya, Turkey

Eurasian Journal of Medicine, 2019
Objective: The rates of seropositivity, seroconversion and fetal infection with human cytomegalovirus were analyzed in pregnant women and newborn cord blood in this study.
Keziban Dogan, Ayse Kafkasli, Cihan Kaya, Huseyin Cengiz   +3 more
doaj   +1 more source

Towards a Prophylactic Vaccine for the Prevention of HCMV Infection

Vaccines, 2021
Human cytomegalovirus (HCMV) or human herpesvirus 5, is a ubiquitous human herpesvirus, which can cause severe disease in immunocompromised patients (AIDS patients and solid organ transplant or hematopoietic stem cell transplant recipients) [...]
Gaëtan Ligat, Sophie Alain, Sébastien Hantz   +2 more
doaj   +1 more source

Human cytomegalovirus entry into cells [PDF]

Current Opinion in Virology, 2012
HCMV entry into different cell types involves distinct pathways and different gH/gL complexes. Entry into fibroblasts involves direct fusion with the plasma membrane and requires gH/gL but not gH/gL/UL128-131, while entry into epithelial and endothelial cells involves macropinocytosis and fusion with endosomes and requires gH/gL/UL128-131.
Adam L, Vanarsdall, David C, Johnson
openaire   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH

Communications Biology, 2022
A panel of neutralizing human monoclonal antibodies targeting human cytomegalovirus offers a combination approach geared toward virus entry and replication to prevent viral dissemination.
Andrea J. Parsons, Sabrina I. Ophir, J. Andrew Duty, Thomas A. Kraus, Kathryn R. Stein, Thomas M. Moran, Domenico Tortorella   +6 more
doaj   +1 more source