Results 71 to 80 of about 9,097,628 (294)

Characterization of the major immediate-early polypeptides encoded by murine cytomegalovirus [PDF]

, 1985
The immediate-early (IE) infected cell proteins induced by the murine cytomegalovirus (Smith strain) were studied. These polypeptides were identified as IE proteins by their synthesis in the presence of actinomycin D after removal from a protein ...
Fibi, Mathias R., Koszinowski, Ulrich H., Keil, Günther M.   +2 more
core   +1 more source

Evaluation of the possible role of HPV16, CMV and EBV in Cervical Carcinoma progression using In Situ Hybridization technique

Diyala Journal of Medicine, 2019
Background:   Cervical carcinoma was considered as a major problem and life threaten of women; therefore it is worthy to study the association of Epstein–Barr virus and cytomegalovirus co-infection with human papillomavirus type 16 in uterine cervical ...
Jasim Mohammed Muhsin, Sahira Hamdan Abbas   +1 more
doaj   +2 more sources

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Cytomegalovirus infection in patients after orthotopic liver transplantation (clinical report)

Журнал инфектологии, 2019
Herpes viruses are widespread in the human population, they are able to infect almost all organs and systems of the body. Currently, 8 serotypes of herpesviruses pathogenic for humans are known: herpes simplex viruses of the 1st and 2nd. type, chickenpox
D. O. Efremov, O. A. Gerasimova, K. V. Kozlov, I. A. Gabdrakhmanov, K. V. Zhdanov   +4 more
doaj   +1 more source

Latency and reactivation of human cytomegalovirus

Journal of General Virology, 2006
Human cytomegalovirus (HCMV) persists as a subclinical, lifelong infection in the normal human host, maintained at least in part by its carriage in the absence of detectable infectious virus – the hallmark of latent infection. Reactivation from latency in immunocompromised individuals, in contrast, often results in serious disease.
John, Sinclair, Patrick, Sissons
openaire   +2 more sources

A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints

Advanced Science, EarlyView.
ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu, Jun Yang, Yuhang Zhang, Xiaoli Xue   +3 more
wiley   +1 more source

Sequential anti-cytomegalovirus response monitoring may allow prediction of cytomegalovirus reactivation after allogeneic stem cell transplantation [PDF]

, 2012
Background: Reconstitution of cytomegalovirus-specific CD3+CD8+ T cells (CMV-CTLs) after allogeneic hematopoietic stem cell transplantation (HSCT) is necessary to bring cytomegalovirus (CMV) reactivation under control. However, the parameters determining
Matthias Eder (21135), Borchers, Sylvia, Benno Wölk, Sylvia Borchers, Arnold Ganser, Pabst, Brigitte, Mischak-Weissinger, Eva Maria, Michael Stadler, Elke Dammann, Andrea Jarisch, Lehrnbecher, Thomas, Arnold Ganser (4454), Eva M. Weissinger (111202), Meral Yildiz, Schneider, Gisbert, Matthias Eder, Peter Bader, Melanie Bremm (111153), Koehl, Ulrike, Thomas Klingebiel, Michael Stadler (111171), Ulrike Koehl, Hans Martin, Benno Wölk (111163), Stadler, Michael, Thomas Lehrnbecher, Sylvia Borchers (111150), Wölk, Benno, Hans Martin (111179), Meral Yildiz (111168), Dammann, Elke, Thomas Klingebiel (111191), Brigitte Pabst (111160), Bader, Peter, Eder, Matthias, Jarisch, Andrea, Brigitte Pabst, Gisbert Schneider, Elke Dammann (111158), Gisbert Schneider (17096), Ulrike Koehl (111209), Thomas Lehrnbecher (111156), Klingebiel, Thomas, Esser, Ruth, Eva M. Weissinger, Ruth Esser (111165), Ganser, Arnold, Yildiz, Meral, Melanie Bremm, Peter Bader (111174), Eva M Weissinger, Bremm, Melanie, Andrea Jarisch (111185), Ruth Esser, Weissinger, Eva M., Köhl, Ulrike, Martin, Hans, Bader Peter, Klingebiel Thomas, Weissinger Eva M., Bremm Melanie, Koehl Ulrike, Pabst Brigitte, Martin Hans, Dammann Elke, Eder Matthias, Yildiz Meral, Jarisch Andrea, Stadler Michael, Wölk Benno, Esser Ruth, Ganser Arnold, Lehrnbecher Thomas, Borchers Sylvia, Schneider Gisbert   +74 more
core   +2 more sources

Spliced transcripts of human cytomegalovirus [PDF]

Journal of Virology, 1993
The availability of the human cytomegalovirus (HCMV) genomic sequence has resulted in more extensive knowledge of the overall coding capacity of the virus. Using polymerase chain reaction and rapid sequencing techniques, we have studied the splicing of mRNAs from a number of the predicted open reading frames (ORFs). Splicing was found between the UL122(
W D, Rawlinson, B G, Barrell
openaire   +2 more sources

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

The human cytomegalovirus US28 protein is located in endocytic vesicles and undergoes constitutive endocytosis and recycling [PDF]

, 2001
Genes encoding chemokine receptor-like proteins have been found in herpes and poxviruses and implicated in viral pathogenesis. Here we describe the cellular distribution and trafficking of a human cytomegalovirus (HCMV) chemokine receptor encoded by the ...
Fraile-Ramos, A, Marsh, M, Alberto Fraile-ramos, Schwartz, TW, Mark Marsh, Kledal, TN, Katherine Bowers, Pelchen-Matthews, A, Thomas N. Kledal, Schwartz, T W, Kledal, T N, Bowers, K, Annegret Pelchen-matthews, Thue W. Schwartz   +13 more
core