Results 11 to 20 of about 19,338 (133)

IE1 of Human Cytomegalovirus Inhibits Necroptotic Cell Death via Direct and Indirect Modulation of the Necrosome Complex

Viruses
Programmed necrosis is an integral part of intrinsic immunity, serving to combat invading pathogens and restricting viral dissemination. The orchestration of necroptosis relies on a precise interplay within the necrosome complex, which consists of RIPK1,
Anna Theresa Heusel, Sophie Rapp, Thomas Stamminger, Myriam Scherer   +3 more
doaj   +2 more sources

ANALYSIS OF ELECTRICITY CONSUMPTION OF INDUCTION MOTORS OF IE1 AND IE2 EFFICIENCY CLASSES IN A 11 kW PUMP INSTALLATION

Electrical engineering & Electromechanics, 2020
Purpose. Comparative analysis of energy consumption indicators of electric motors of different energy efficiency classes in an electric drive of a centrifugal pump with power of 11 kW of a water supply system with throttle regulation. Methodology.
S. Kh. Oshurbekov, V. M. Kazakbaev, V. A. Prakht, V. A. Dmitrievskii, A. S. Paramonov   +4 more
doaj   +2 more sources

Improving the production of baculovirus expression vector by overexpression of IE0/IE1 through tandem promoter.

PLoS ONE
The baculovirus expression vector system, known for its protein production in insect cells and has been criticized for its relatively low expression capacity.
Sijun He, Weining Li, Ruirui Zhang, Hao Nan, Wangcheng Song, Xiaodong Xu   +5 more
doaj   +2 more sources

Identification and HLA-tetramer-validation of human CD4+ and CD8+ T cell responses against HCMV proteins IE1 and IE2.

PLoS ONE, 2014
Human cytomegalovirus (HCMV) is an important human pathogen. It is a leading cause of congenital infection and a leading infectious threat to recipients of solid organ transplants as well as of allogeneic hematopoietic cell transplants.
Peter Braendstrup, Bo Kok Mortensen, Sune Justesen, Thomas Osterby, Michael Rasmussen, Andreas Martin Hansen, Claus Bohn Christiansen, Morten Bagge Hansen, Morten Nielsen, Lars Vindeløv, Søren Buus, Anette Stryhn   +11 more
doaj   +2 more sources

Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions.

PLoS Pathogens, 2014
PML nuclear bodies (PML-NBs) are enigmatic structures of the cell nucleus that act as key mediators of intrinsic immunity against viral pathogens. PML itself is a member of the E3-ligase TRIM family of proteins that regulates a variety of innate immune ...
Myriam Scherer, Stefan Klingl, Madhumati Sevvana, Victoria Otto, Eva-Maria Schilling, Joachim D Stump, Regina Müller, Nina Reuter, Heinrich Sticht, Yves A Muller, Thomas Stamminger   +10 more
doaj   +2 more sources

Human Cytomegalovirus IE1 Impairs Neuronal Migration by Downregulating Connexin 43

Journal of Virology, 2023
Congenital CMV (cCMV) infection causes neurological sequelae in newborns. Recent studies of cCMV pathogenesis in animal models reveal ventriculomegaly and cortical atrophy associated with impaired neural progenitor cell (NPC) proliferation and migration.
Sheng-Nan Huang, Yu-Ting Pan, Yue-Peng Zhou, Xian-Zhang Wang, Meng-Jie Mei, Bo Yang, Dong Li, Wen-Bo Zeng, Shuang Cheng, Jin-yan Sun, Han Cheng, Fei Zhao, M. Luo   +12 more
semanticscholar   +1 more source

A SLiM-dependent conformational change in baculovirus IE1 controls its focus formation ability

bioRxiv, 2023
The baculovirus IE1 gene encodes a multifunctional protein that is essential for both DNA replication and RNA transcription of the virus. Prior to viral DNA replication, IE1 promotes early gene transcription when localized in hr-dependent foci.
T. Nagamine, Y. Sako
semanticscholar   +1 more source

Comparative Transcriptome Analysis Reveals That WSSV IE1 Protein Plays a Crucial Role in DNA Replication Control

International Journal of Molecular Sciences, 2022
For DNA viruses, the immediate-early (IE) proteins are generally essential regulators that manipulate the host machinery to support viral replication.
Yixi Chen, Gaochun Wu, Chuanqi Wang, Huimin Zhang, Jinghua Zhu, Yueling Zhang, Zhongyang Lin, Defu Yao   +7 more
semanticscholar   +1 more source

Identification of the Key Functional Domains of Bombyx mori Nucleopolyhedrovirus IE1 Protein

International Journal of Molecular Sciences, 2022
The immediate early protein 1 (IE1) acts as a transcriptional activator and is essential for viral gene transcription and viral DNA replication. However, the key regulatory domains of IE1 remain poorly understood.
Zhigang Hu, Z. Dong, Jianghao Miao, Ke Li, Jie Wang, Peng Chen, Cheng Lu, M. Pan   +7 more
semanticscholar   +1 more source

Bright and Early: Inhibiting Human Cytomegalovirus by Targeting Major Immediate-Early Gene Expression or Protein Function

Viruses, 2020
The human cytomegalovirus (HCMV), one of eight human herpesviruses, establishes lifelong latent infections in most people worldwide. Primary or reactivated HCMV infections cause severe disease in immunosuppressed patients and congenital defects in ...
Catherine S. Adamson, Michael M. Nevels   +1 more
doaj   +1 more source