Results 21 to 30 of about 24,692 (220)

A Slim-Dependent Conformational Change in Baculovirus Ie1 Controls its Focus Formation Ability

Journal of General Virology, 2023
The baculovirus IE1 gene encodes a multifunctional protein that is essential for both DNA replication and RNA transcription of the virus. Prior to viral DNA replication, IE1 promotes early gene transcription when localized in hr -dependent foci.
Toshihiro Nagamine, Yasushi Sako
openalex   +3 more sources

Proteomics analysis reveals a critical role for the WSSV immediate-early protein IE1 in modulating the host prophenoloxidase system

Virulence, 2022
White spot syndrome virus (WSSV) is a large, enveloped, double-stranded DNA virus that threatens shrimp aquaculture worldwide. So far, the mechanisms of WSSV-host interactions are ill-defined.
Chuanqi Wang, Menghao Wei, Gaochun Wu, Lixuan He, Jinghua Zhu, Jude Juventus Aweya, Xiuli Chen, Yongzhen Zhao, Yueling Zhang, Defu Yao   +9 more
doaj   +1 more source

Induction of apoptosis by baculovirus transactivator IE1 [PDF]

Journal of Virology, 1996
Apoptosis is induced upon infection of SF-21 cells by mutants of the baculovirus Autographa californica nuclear polyhedrosis virus (AcMNPV) lacking a functional p35 gene which encodes a stoichiometric inhibitor of members of the interleukin-1beta converting enzyme family of cysteine proteases (N.J. Bump et al, Science 269:1885-1888, 1995; R.J. Clem, M.
E A, Prikhod'ko, L K, Miller
openaire   +2 more sources

Analysis of human cytomegalovirus-encoded SUMO targets and temporal regulation of SUMOylation of the immediate-early proteins IE1 and IE2 during infection. [PDF]

PLoS ONE, 2014
Post-translational modification of proteins by members of the small ubiquitin-like modifier (SUMO) is involved in diverse cellular functions. Many viral proteins are SUMO targets and also interact with the cellular SUMOylation system.
Eui Tae Kim, Young-Eui Kim, Ye Ji Kim, Myoung Kyu Lee, Gary S Hayward, Jin-Hyun Ahn   +5 more
doaj   +1 more source

The essential role of guinea pig cytomegalovirus (GPCMV) IE1 and IE2 homologs in viral replication and IE1-mediated ND10 targeting

Virology, 2017
Guinea pig cytomegalovirus (GPCMV) immediate early proteins, IE1 and IE2, demonstrated structural and functional homologies with human cytomegalovirus (HCMV). GPCMV IE1 and IE2 co-localized in the nucleus with each other, the viral polymerase and guinea pig ND10 components (gpPML, gpDaxx, gpSp100, gpATRX).
Julia Hornig, K. Yeon Choi, Alistair McGregor   +2 more
openalex   +3 more sources

Human cytomegalovirus IE1 and IE2 proteins block apoptosis [PDF]

Journal of Virology, 1995
Human cytomegalovirus-infected fibroblasts are resistant to the induction of apoptosis by superinfection with a mutant adenovirus unable to produce the viral E1B 19-kDa protein that normally causes an E1A protein-mediated apoptotic response. Two cytomegalovirus gene products that block apoptosis were identified.
H, Zhu, Y, Shen, T, Shenk
openaire   +2 more sources

Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase. [PDF]

PLoS Pathogens, 2017
Congenital human cytomegalovirus (HCMV) infection is the leading cause of neurological disabilities in children worldwide, but the mechanisms underlying these disorders are far from well-defined.
Xi-Juan Liu, Bo Yang, Sheng-Nan Huang, Cong-Cong Wu, Xiao-Jun Li, Shuang Cheng, Xuan Jiang, Fei Hu, Ying-Zi Ming, Michael Nevels, William J Britt, Simon Rayner, Qiyi Tang, Wen-Bo Zeng, Fei Zhao, Min-Hua Luo   +15 more
doaj   +1 more source

DNA-dependent transregulation by IE1 of Autographa californica nuclear polyhedrosis virus: IE1 domains required for transactivation and DNA binding [PDF]

Journal of Virology, 1997
IE1 is the principal early transregulator of Autographa californica multicapsid nuclear polyhedrosis virus (AcMNPV). The 582-residue protein stimulates viral transcription and binds as a dimer to 28-bp palindromic repeats (28-mers) comprising the AcMNPV homologous region (hr) transcription enhancers.
S M, Rodems, S S, Pullen, P D, Friesen
openaire   +2 more sources

Bright and Early: Inhibiting Human Cytomegalovirus by Targeting Major Immediate-Early Gene Expression or Protein Function

Viruses, 2020
The human cytomegalovirus (HCMV), one of eight human herpesviruses, establishes lifelong latent infections in most people worldwide. Primary or reactivated HCMV infections cause severe disease in immunosuppressed patients and congenital defects in ...
Catherine S. Adamson, Michael M. Nevels   +1 more
doaj   +1 more source

IE1 of Autographa californica Multiple Nucleopolyhedrovirus Activates Low Levels of Late Gene Expression in the Absence of Virus RNA Polymerase

Microbiology Spectrum, 2023
Early and late gene expressions of baculoviruses have been known to rely on host RNA polymerase II and a virus-encoded RNA polymerase, separately. In this study, we found that Autographa californica multiple nucleopolyhedrovirus (AcMNPV) recombinant ...
Yong Qi, Shan-Shan Wang, Lu-Lin Li
doaj   +1 more source