The role of IFN-gamma in Humoral immune response for HCMV antigens among pregnant women
Background: Human cytomegalovirus (HCMV) is a highly host-specific virus belongs to the β-herpesvirus subfamily, which is a leading cause of congenital infections.
Staar Mohammed Qader+1 more
doaj +1 more source
Structural organization, expression, and functional characterization of the murine cytomegalovirus immediate-early gene 3. [PDF]
We have previously defined ie3 as a coding region located downstream of the ie1 gene which gives rise to a 2.75-kb immediate-early (IE) transcript. Here we describe the structural organization of the ie3 gene, the amino acid sequence of the gene product,
Bühler, Bernhard+3 more
core +1 more source
Leading From Higher Headquarters
ABSTRACT This study explores the relationship between self‐efficacy, task acceptance, and goal setting among senior leaders operating in higher headquarters, particularly within the context of hybrid warfare. The aim is to describe the factors that influence the decision‐making (DM) performance of police and military leaders involved in collaborative ...
Jostein Mattingsdal, Roar Espevik
wiley +1 more source
Murine cytomegalovirus immediate-early 1 gene expression correlates with increased GVHD after allogeneic hematopoietic cell transplantation in recipients reactivating from latent infection. [PDF]
The success of allogeneic (allo) hematopoietic cell transplantation (HCT) is limited by its treatment related complications, mostly graft versus host disease (GVHD) and fungal and viral infections.
Senthilnathan Palaniyandi+6 more
doaj +1 more source
The Bioengineering of Microspheric Skin Organoids and Their Application in Drug Screening
A novel method for the preparation of uniform microspheric skin organoids via spinning bioreactors is developed. The organoid consists of a core‐shell structure to mimic the bilayered skin structure with the epidermis on the surface. For efficient drug screening, the organoid is equipped with a luciferase reporter to detect canonical Wnt signaling, and
Jundong Xie+5 more
wiley +1 more source
Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication
Viruses manipulate host ROS as a strategy to achieve successful infection. WSSV exploits Nrf2 pathway to maintain ROS homeostasis and establishes a positive feedback loop to facilitate WSSV replication. Wsv220 competitively binds to Keap1 to activate Nrf2. Nrf2 up‐regulates LvG6PDH to produce more NADPH and GSH to eliminate excessive ROS.
Honghui He+6 more
wiley +1 more source
Background Versatile transgenic manipulation of skeletal muscle requires knowledge of the expression profiles of diverse promoter/enhancer elements in the transcriptionally specialized fiber types of which muscle is composed.
Hastings Kenneth EM, Hallauer Patricia L
doaj +1 more source
Inhibition of human cytomegalovirus immediate early gene expression and growth by a novel RNase P ribozyme variant. [PDF]
We have previously engineered new RNase P-based ribozyme variants with improved in vitro catalytic activity. In this study, we employed a novel engineered variant to target a shared mRNA region of human cytomegalovirus (HCMV) immediate early proteins 1 ...
Xu Sun+13 more
doaj +1 more source
Enerji verimliliği, tüm dünyanın üzerinde dikkatle durduğu önemli bir konudur. Dünyada üretilen elektrik enerjinin % 43 - 45’ini elektrik motoru tarafından tükettiği tahmin edilmektedir.
İsmail Cebeci+3 more
doaj +1 more source
The 89,000-Mr murine cytomegalovirus immediate-early protein activates gene transcription [PDF]
To study trans-activation of gene expression by murine cytomegalovirus (MCMV) immediate-early (IE) proteins, the IE coding region 1 (ie1), which encodes the 89,000-Mr IE phosphoprotein (pp89), was stably introduced into L cells.
Ebeling-Keil, Angelika+5 more
core +1 more source