Results 101 to 110 of about 140,805 (301)

Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection. [PDF]

, 2020
Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the response of MAIT cells during acute HIV-1 infection utilizing the RV217 cohort with paired ...
Ananworanich, Jintanat, Bolton, Diane L, Costanzo, Margaret C, Creegan, Matthew, Dias, Joana, Eller, Leigh Anne, Eller, Michael A, Kibuuka, Hannah, Kim, Dohoon, Kosgei, Josphat, Krebs, Shelly J, Lal, Kerri G, Leeansyah, Edwin, Maganga, Lucas, Michael, Nelson L, Nitayaphan, Sorachai, Paquin-Proulx, Dominic, Phuang-Ngern, Yuwadee, Robb, Merlin L, Sacdalan, Carlo, Sandberg, Johan K, Schuetz, Alexandra, Shacklett, Barbara L, Slike, Bonnie M   +23 more
core  

Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure. [PDF]

, 2017
Vδ2+ γδ T cells are semi-innate T cells that expand markedly following P. falciparum (Pf) infection in naïve adults, but are lost and become dysfunctional among children repeatedly exposed to malaria.
Bowen, Katherine, Boyle, Michelle J, Budker, Rachel, Dorsey, Grant, Farrington, Lila A, Feeney, Margaret E, Greenhouse, Bryan, Jagannathan, Prasanna, Kamya, Moses R, Katureebe, Agaba, Lutwama, Fredrick, McIntyre, Tara I, Musinguzi, Kenneth, Nalubega, Mayimuna, Naluwu, Kate, Nankya, Felistas, Rek, John, Sikyomu, Esther   +17 more
core   +2 more sources

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source

Experience of cytokine therapy in the treatment of recurrent cervical cancer

Медицинская иммунология
Cervical cancer is the most common malignant tumor of the female genital organs. In general, the prognosis in patients with advanced cervical cancer is unfavorable.
E. A. Bykova, N. A. Falaleeva, S. A. Myalina, P. V. Shegai, L. Yu. Grivtsova   +4 more
doaj   +1 more source

Data from MHC Class II is Induced by IFNγ and Follows Three Distinct Patterns of Expression in Colorectal Cancer Organoids

, 2023
Oliver Pickles, Kasun Wanigasooriya, Anetta Ptasinska, Akshay J. Patel, Helen L. Robbins, Claire Bryer, Celina Whalley, Louise Tee, Neeraj Lal, Claudia M.A. Pinna, Nahla Elzefzafy, Philippe Tanière, Andrew D. Beggs, Gary Middleton   +13 more
openalex   +1 more source

Tumor derived Microvesicles enhance cross-processing ability of clinical grade Dendritic Cells [PDF]

, 2018
Tumor cells release extracellular microvesicles (MVs) in the microenvironment to deliver biological signals to neighbouring cells as well as to cells in distant tissues.
Battisti, Federico, Belleudi, Francesca, Claudia De Archangelis,, DI FILIPPO, Alessandra, Dionisi, Marco, Napoletano, Chiara, Nuti, Marianna, RAHIMI KOSHKAKI, Hassan, Rughetti, Aurelia, Ruscito, Ilary, Torrisi, Maria Rosaria, Zizzari, ILARIA GRAZIA   +11 more
core   +1 more source

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, EarlyView.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenkel, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source

Decision letter for "Ursodeoxycholic acid impairs liver‐infiltrating T cell chemotaxis through IFNγ and CX3CL1 production in primary biliary cholangitis"

, 2021

openalex   +1 more source

The role of the A C395 IFNGR1 mutation in determining susceptibility to intracellular infection in Malta [PDF]

, 2012
Background: The first human mycobacterial susceptibility gene was identified amongst four children on the island of Malta in 1995. All affected children were homozygous for a nonsense mutation at position 395 of the interferon gamma receptor 1 (IFNGR1 ...
Anderson, Suzanne T., Attard Montalto, Simon, Felice, Alex, Hibberd, Martin, Levin, Mike, Mangion, Mariella, Newport, Melanie J.   +6 more
core  

Tricks to translating TB transcriptomics. [PDF]

, 2015
Transcriptomics and other high-throughput methods are increasingly applied to questions relating to tuberculosis (TB) pathogenesis. Whole blood transcriptomics has repeatedly been applied to define correlates of TB risk and has produced new insight into ...
Coussens, AK, Deffur, A, Wilkinson, RJ
core   +1 more source