Results 111 to 120 of about 140,805 (301)

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Studying interconnections of cytokines and their diagnostic effectiveness when assessing severity grade in COVID-19 patients

Медицинская иммунология
The origins and intensity of human immune response to SARS-CoV-2 infection depend on many factors. The anti-infectious immune response includes both cellular and humoral components.
N. V. Davydova, S. B. Putkov, D. V. Reshetnyak, S. P. Kazakov   +3 more
doaj   +1 more source

SSupplementary Figure 1 from Toll-like Receptor Agonist Imiquimod Facilitates Antigen-Specific CD8⁺ T-cell Accumulation in the Genital Tract Leading to Tumor Control through IFNγ

, 2023
Ruey-Shyang Soong, Liwen Song, Janson Trieu, Jayne Knoff, Liangmei He, Ya-Chea Tsai, Warner K. Huh, Yung-Nien Chang, Wen‐Fang Cheng, Richard B.S. Roden, T.-C. Wu, Cornelia L. Trimble, Chien‐Fu Hung   +12 more
openalex   +1 more source

A PPAR-gamma, egy lipidek által aktivált transzkripciós faktor aktivitásának szabályozása a makrofágok különböző állapotaiban = Regulation of the activity of a lipid-activated transcription factor, PPAR-gamma in macrophages [PDF]

, 2009
A Peroxisome Proliferator-activated Receptor y (PPARy) egy lipidek által aktivált transzkripciós faktor, mely a lipidanyagcsere és a gyulladás szabályozásával olyan folyamatokban vesz részt, mint az érelmeszesedés és diabétesz.
Szántó, Attila
core  

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

Advanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin, Koji Nagaoka, Myrofora Panagi, Akihiro Hosoi, Fotios Mpkeris, Pengwen Chen, Thahomina T. Khan, Margaret R. Martin, Changbo Sun, Chrysovalantis Voutouri, Maria Louca, Panagiotis Papageorgis, Akira Sumiyoshi, Nobuhiro Nitta, Kazuyoshi Takeda, Ichio Aoki, Kazunori Kataoka, Triantafyllos Stylianopoulos, Kazuhiro Kakimi, Horacio Cabral   +19 more
wiley   +1 more source

Usage of IFNγ or TNFα-T in protocols for obtaining cytokine-induced killer cells for adoptive immunotherapy

Медицинская иммунология
Methods of immunocorrection based on injection of in vitro activated autologous leukocytes are becoming widespread. Our previous studies suggest that implementation of immunotherapy with in vitro activated lymphocytes using cytokines is effective for the
Yu. V. Gelm, L. Yu. Grivtsova, I. A. Pasova, Т. V. Konstantinova, Т. Yu. Mushkarina, S. A. Ivanov, A. D. Kaprin   +6 more
doaj   +1 more source

Movie S3 from CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1

, 2023
Chahrazade Kantari‐Mimoun, Sarah Barrin, Lene Vimeux, Sandrine Haghiri, Claire Gervais, Sandy Joaquina, Joerg Mittelstaet, Nadine Mockel-Tenbrinck, Ali Kinkhabwala, Diane Damotte, Audrey Lupo, Mathilde Sibony, Marco Alifano, Elisabetta Dondi, Nadège Bercovici, Alain Trautmann, Andrew Kaiser, Emmanuel Donnadieu   +17 more
openalex   +1 more source

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

Advanced Science, EarlyView.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li, Jiaqiang Jiang, Yuping Zhou, Xinyuan Mao, Haotian Wen, Zhian Chen, Yutong Wang, Cong Huang, Yanfeng Hu   +8 more
wiley   +1 more source

Cytokine profile in the patients with bronchial asthma of different endotypes after vaccination against pneumococcus

Медицинская иммунология
Numerous observations of patients with bronchial asthma (BA) vaccinated against pneumococcal infection have revealed a significantly reduced frequency of exacerbations and hospitalisations after immunisation.
A. M. Kostinov, A. Yu. Konishcheva, A. D. Protasov, M. P. Kostinov   +3 more
doaj   +1 more source

AUTOANTIBODIES AND CYTOKINE PROFILE IN PATIENTS WITH GRAVES–BASEDOW DISEASE AND THEIR DYNAMICS DURING THIONAMIDE THERAPY

Медицинская иммунология, 2014
. Role of cytokines in autoimmune reactions in Graves–Basedow disease (GBD) is undisputable. It has been shown, that dynamic alterations in serum Th1 and Th2 marker cytokines are dependent on disease stage.
E. V. Markelova, V. V. Lazanovich
doaj   +1 more source