Results 231 to 240 of about 140,805 (301)

Figure S3 from IFNγ-Induced PD-L1⁺MHCII⁺ Macrophages and Tim-3⁺ Tumor-Reactive CD8⁺ T Cells Predict a Response to Anti–PD-1 Therapy in Tumor-Bearing Mice [PDF]

Jelena Gabrilo, Sylvie Vande Velde, Coralie Henin, Sébastien Denanglaire, Abdulkader Azouz, Louis Boon, Benoı̂t J. Van den Eynde, Muriel Moser, Stanislas Goriely, Oberdan Léo   +9 more
openalex   +1 more source

624 IFNγ secreted by tebentafusp (IMCgp100)-redirected T cells inhibits expression of melanin synthesis pathway genes in healthy melanocytes

, 2020
Mariantonella Vardeu, David Depoil, Camille Britton-Rivet, Jane Houghton, Jane Harper, Gabrielle Le Provost, Laura Collins, Koustubh Ranade, Adel Benlahrech   +8 more
openalex   +1 more source

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

Microbial influences on immune modulation and colorectal cancer progression through combined transcriptomic and microbiomic analysis

iMetaOmics, EarlyView.
Schematic representation of the distinct tumor microenvironment characteristics in CA1 and CA2 subtypes. CA1 illustrates an immune‐active tumor microenvironment characterized by elevated infiltration of immune cells, particularly CD8 + T cells and macrophages, and enhanced IFN‐γ signaling.
Shuting Xia, Likun Wang, Yangzhuo Xu, Jiaqi Zhang, Zeyang Zhou, Libing Sun, Heng Li, Chungen Xing, Jialu Mao, Yina Liu, Fulin Yang, Ling Zhong, Jiancheng Xu, Xiaodong Yang, Zhemin Zhou   +14 more
wiley   +1 more source

Microbial-derived immunostimulatory small molecule augments anti-PD-1 therapy in lung cancer. [PDF]

Cell Rep Med
Newsome RC, Liu H, Agbodzi B, Gharaibeh RZ, Zhou L, Jobin C.   +5 more
europepmc   +1 more source

Napabucasin transforms liver microenvironment and boosts immunotherapy efficacy by converting potential metastases into “hot” tumors

Interdisciplinary Medicine, EarlyView.
Napabucasin reduces liver metastases by reprogramming the hepatic microenvironment. It induces hepatocyte secretion of CCL21 via c‐Fos activation, recruiting lymphocytes and converting “cold” metastases into immunologically “hot” tumors. This effect is liver‐specific and independent of cancer cells.
Qiongqiong Wang, Jiaqi Zhou, Hang Qiao, Yifan Jia, Ling Ye, Zeli Li, Jiahe Ouyang, Haoxian Zhou, Kangxin Zeng, Xuemeng Wang, Yixian Wang, Yang Zhang, Yupeng Zhang, Yizhou Cai, Yutao Hu, Minzhe Zhang, Wenwei Xu, Zhenzhen Wu, Xiaofang Qiu, Li Lin   +19 more
wiley   +1 more source

Oesophageal Epithelial Cell-Intrinsic MHCII Regulates Food Antigen-Dependent Eosinophilic Esophagitis in an IFNγ-Dependent Manner. [PDF]

Clin Exp Allergy
Rodríguez-López EM, Clement RL, Lal M, Zhou Y, Carro SD, Assenmacher CA, Gautam R, Beers J, Muir AB, Spergel JM, Ruffner MA, Eisenlohr LC, Hill DA.   +12 more
europepmc   +1 more source

Surface antigen SAG1 mediates Toxoplasma gondii fitness and host cell attachment in IFNγ-stimulated cells

Olivia G. Cohen, Parag Maru, Qin‐Li Liang, Jeroen P. J. Saeij   +3 more
openalex   +1 more source

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Bone marrow-derived CD169⁺ macrophages promote autoimmune hepatitis by recruiting CCR2⁺ monocytes via secreting CCL12. [PDF]

Exp Mol Med
Lin B, Zhang H, Zhu P, Chen J, Li D, Zhou J, Zhang T, Chen Q, Tang C, Song X, Zeng H, Wang J, Zhang J, You Z, Ma X, Yu C.   +15 more
europepmc   +1 more source