Results 251 to 260 of about 140,805 (301)

Variability in German cockroach extract composition greatly impacts T cell potency in cockroach-allergic donors [PDF]

, 2019
Bacharier, Leonard B, Beigelman, Avraham, et al,   +2 more
core   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Single-Cell Clonal Lineage Tracing Identifies the Transcriptional Program Controlling the Cell-Fate Decisions by Neoantigen-Specific CD8+ T Cells. [PDF]

Cancer Immunol Res
Luo Y, Hu T, Yao C, Wu T.
europepmc   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury. [PDF]

Signal Transduct Target Ther
Fischer JC, Göttert S, Giller M, Heinrich P, Fan K, Khalid O, Walther CN, Drießlein M, Nefzger SM, Eisenkolb G, Timnik VR, Jarosch S, Klostermeier L, Engleitner T, Strieder N, Gebhard C, Diederich S, Schmid NA, Lansink Rotgerink L, Joachim L, Ghimire S, Vonbrunn E, Büttner-Herold M, Remke M, Steiger K, Öllinger R, Rad R, Wolff D, Feuerer M, Hoffmann P, Edinger M, Rehli M, Tschurtschenthaler M, Kepp O, Kroemer G, Thiele Orberg E, Combs SE, Herr W, Bassermann F, Busch DH, Holler E, Heidegger S, Poeck H.   +42 more
europepmc   +1 more source

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei, Mervat M. Omran, Qiwei Yang, Sandra Madueke‐Laveaux, Ami R. Zota, Ayman Al‐Hendy, Mohamed Ali   +6 more
wiley   +1 more source

The content of IL-1b, IL-4, IL-6, IL-10, TNF-α and IFNγ in bladder cancer depend by a tumor grade

, 2019
V. Dmytryk, A. Vyshenska, I. Proshkina, О. Savchuk, P. Yakovlev, Tetiana Andriichuk   +5 more
openalex   +2 more sources

AAKD: A standardized and comprehensive acupuncture anesthesia knowledge platform for enhanced recovery after surgery and mechanism

VIEW, EarlyView.
Acupuncture anesthesia (AA) is an application of acupuncture innovation in surgical operations, combined with anesthetic techniques, and is a model of integrated Chinese and Western medicine. We proposed the Acupuncture Anesthesia Knowledge Database (AAKD), in which all data have been meticulously curated by field experts and assessed by a multi ...
Ying Wang, Honglian Huang, Chenchen Feng, Xueli Zhang, Weiting Wang, Ziyi Wei, Jing Li, Xintong Yu, Hanzhi Lu, Chunfang Gao, Ke Wang, Jia Zhou   +11 more
wiley   +1 more source

Toll like receptor agonist effects on human CD8+ T cell activation and expression of T cell checkpoint receptors. [PDF]

Hum Vaccin Immunother
Jeon D, Moseman JE, Hill E, McNeel DG.
europepmc   +1 more source