Results 271 to 280 of about 140,805 (301)

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Vessel‐associated microglia are differentially activated and distributed in relation to systemic infection and Alzheimer's disease

Brain Pathology, EarlyView.
This post‐mortem study revealed an increased density of vessel‐associated microglia (VAM) in the temporal lobe in systemic infection and Alzheimer's disease. VAM density was related to brain cytokine levels and markers of cerebrovascular dysfunction and BBB leakage indicating that activated VAM contributes to neurovascular injury in Alzheimer's disease.
Oliver Milner, Robert A. Fisher, Daniel J. Asby, Stephen Cross, Delphine Boche, J. Scott Miners   +5 more
wiley   +1 more source

Sex in Immune Cells and Parasitic Diseases - A Complex Relationship. [PDF]

Immunol Rev
Honecker B, Hansen CS, Lotter H.
europepmc   +1 more source

Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?

British Journal of Pharmacology, EarlyView.
Psychedelic drugs that activate 5‐HT2A receptors have been long used for cultural, medicinal and recreational purposes. Interest in psychedelics for treating psychiatric disorders has resurged recently and is well documented; less well recognised are their anti‐inflammatory properties. Growing evidence now demonstrates that psychedelics modulate immune
Omar Qureshi, Jamie Cowley, Ashley Pegg, Alison J. Cooper, John Gordon, Catherine A. Brady, Antonio Belli, Sam Butterworth, Rachel Upthegrove, Nick Andrews, Nicholas M. Barnes   +10 more
wiley   +1 more source

IFNγ and TNFα optimize salivary gland mesenchymal stromal cells: an alternative to marrow- and adipose-MSCs for radiation xerostomia. [PDF]

Regen Ther
Larsen MC, Gurevic I, Berube L, Vande Loo A, Hanson E, Adam R, Manfrè V, Parker M, Paz C, Galipeau J, Kimple RJ, Blitzer G, McCoy SS.   +12 more
europepmc   +1 more source

Phenotype of OT-I effector cells after CRISPR-Cas9 deletion of IFNγ, related to Fig 5.

Jacob A. Hildebrand (3597290), Noah R. Daniels (20968419), Emma M. Dehm (20968422), Benjamin D. Fisher (20968425), Joseph K. Guter (20968428), Chris J. Janse (7671737), Erin D. Lucas (11994875), Jules A. Sangala (20968431), Trevor N. Tankersley (20968434), Geoffrey T. Hart (3371888), Sara E. Hamilton (7341353)   +10 more
openalex   +1 more source

Induction of IL‐9‐producing CD8+ T cells by ascochlorin derivatives

British Journal of Pharmacology, EarlyView.
A newly synthesised ascochlorin derivative, N184, induces small amounts of IL‐9‐producing CD8+ T cells. N184 improved the survival of CD8+ T cells and enhanced their antitumour activity, partially in an IL‐9‐dependent manner. The antitumour effect was completely dependent on IFNγ secretion rather than the cytotoxic activity of CD8+ T cells.
Natsumi Imano, Mikako Nishida, Miho Tokumasu, Weiyang Zhao, Nahoko Yamashita, Heiichiro Udono   +5 more
wiley   +1 more source

Avoiding the toll of lung injury while driving CAR T cells to the target tumor. [PDF]

J Thorac Dis
Cranwell V, Adusumilli PS, Taleb M.
europepmc   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Glycolytic flux sustains human Th1 identity and effector function via STAT1 glycosylation. [PDF]

Life Sci Alliance
Abir AH, Benz J, Frey B, Bruns H, Krönke G, Gaipl US, Schober K, Mougiakakos D, Mielenz D.   +8 more
europepmc   +1 more source