Results 281 to 290 of about 140,805 (301)

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Anti-PD-L2 immunotherapy is efficacious against melanoma in aged hosts through IL-17 and IFNγ signalling. [PDF]

Nat Commun
Ontiveros CO, Garcia MG, Murray CE, Deng Y, Bai H, Tanner C, Leung B, Li X, Padron A, Reyes RM, Kancharla A, Soh KT, Krishnan S, Chand D, Balasubramanian A, Hegner C, Jakubzick CV, Gupta HB, Turk MJ, Sundrud M, Conejo-Garcia JR, Curiel TJ.   +21 more
europepmc   +1 more source

LCN2‐ACOD1 Signalling Affects the Post‐Injury Regeneration of Skeletal Muscle Through Mediating Ferroptosis

Cell Proliferation, EarlyView.
LCN2 mediates the suppression of C2C12 myoblast proliferation and myotube formation via erastin‐induced ferroptosis. Mechanistically, the LCN2‐ACOD1 axis regulates skeletal muscle growth via mitochondria‐associated ferroptosis, providing a theoretical basis for the prevention and therapy of muscle‐related diseases.
Xiaojing Hao, Hongwei Shi, Di Wu, Rui Liang, Tong Zhao, Wen Sun, Yue Wang, Xiuju Yu, Xiaomao Luo, Yi Yan, Jiayin Lu, Haidong Wang, Juan Wang   +12 more
wiley   +1 more source

A multiplex Mtb-specific FluoroSpot assay measuring IFNγ, IL-2, and TNF-secreting cells can improve accuracy and differentiation across the tuberculosis spectrum. [PDF]

J Clin Microbiol
Folkesson E, Foroogh F, Kleberg L, Kjellgren V, Jakobsson M, Grunewald L, Hellberg J, Ryberg J, Maher Z, Silva CS, Gower MS, Grönlund H, Correia-Neves M, Makower B, Källenius G, Bruchfeld J, Sundling C.   +16 more
europepmc   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Differential regulation of 5-lipoxygenase and leukotriene-C4-synthase expression by IFNγ, IL-4 and IL-13 in human monocytes and macrophages from patients with atopic dermatitis. [PDF]

Inflamm Res
Lietzau S, Traidl S, Riesselmann C, Werfel T, Mommert S.   +4 more
europepmc   +1 more source

Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques [PDF]

, 2017
Diamond, Michael S, et al,, Fox, Julie M, Sukulpovi-Petty, Soila   +3 more
core   +1 more source

The <i>Shigella flexneri</i> effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation. [PDF]

Elife
Saavedra-Sanchez L, Dickinson MS, Apte SS, Zhang Y, De Jong M, Skavicus S, Heaton NS, Alto NM, Coers J.   +8 more
europepmc   +1 more source

Liver metastases dampen IL18-driven γδ T cell activity and immunotherapy responsiveness in colorectal cancer. [PDF]

Cell Rep Med
van Renterghem AWJ, Parra-Martinez M, Witsen M, Verkerk K, Steur M, Zeverijn LJ, Dijkstra KK, Akkari L, Voest EE.   +8 more
europepmc   +1 more source