Results 41 to 50 of about 140,805 (301)

Hormone therapy affecting interferon defense in children with infectious mononucleosis

Инфекция и иммунитет, 2021
23 children diagnosed with acute infectious mononucleosis were hospitalized and examined after a short prednisolone treatment course. Related interferon status during infection was compared with that in 38 patients with acute infectious mononucleosis ...
I. M. Fedorova, S. I. Koteleva, I. V. Kapustin, M. S. Blyakher, E. A. Tulskaya, N. N. Zvereva, M. A. Ilina, M. A. Saifullin, A. A. Samkov, E. V. Vlasov   +9 more
doaj   +1 more source

Additional file 1: Table S1. of Physiological evidence for diversification of IFNι- and IFNβ-mediated response programs in different autoimmune diseases

, 2016
List of 23 type I interferon (IFN) response genes that were measured. Table S2. List of genes that are significantly differentially expressed between patients with systemic lupus erythematosus (SLE) and patients with multiple sclerosis (MS) who were treated with IFNβ. (PDF 116 kb)
Tamarah De Jong, Vosslamber, Saskia, Mantel, Elise, Ridder, Sander De, Wesseling, John, Kraan, Tineke Van Der Pouw, Leurs, Cyra, Hegen, Harald, Deisenhammer, Florian, Killestein, Joep, Lundberg, Ingrid, Jiri Vencovsky, Nurmohamed, Mike, Schaardenburg, Dirkjan Van, Bultink, Irene, Voskuyl, Alexandre, D. Pegtel, Laken, Conny Van Der, Bijlsma, Johannes, Verweij, Cornelis   +19 more
openaire   +1 more source

Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses. [PDF]

, 2018
Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1-4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted therapies5-8, but remains incompletely ...
A Marusyk, AD Rouillard, Amir Reza Aref, AN Hata, Anika Elise Adeni, AR Aref, Brandon Piel, C Henke, Camilla Laulund Christensen, CD Carey, Christine Anne Lydon, CL Christensen, Cloud Peter Paweletz, D Gao, D Hanahan, D Miao, D Pan, D Peng, D Roulois, DA Barbie, DA Rhodes, David Allen Barbie, Debattama Rai. Sen, Diana Miao, DJ Konieczkowski, DP Tabassum, DR Sen, EB Chuong, Evisa Gjini, Ewa Sicinska, F Perocchi, G Bindea, Gao Zhang, Hideki Terai, Hideo Baba, Hideo Watanabe, I Canadas, I Tirosh, Israel Cañadas, J Barretina, J Calbo, J Chen, Jacob Sands, JG Doench, Jong Wook Kim, JT Poirier, JW Kim, KA Hoadley, KB Chiappinelli, Kwok Kin Wong, Lynnette Marie Sholl, Marco Campisi, Masayuki Watanabe, Meenhard Herlyn, MR Junttila, NE Sanjana, O Shalem, Pablo Tamayo, Ravindra Uppaluri, Rohit Thummalapalli, RT Manguso, Russell William Jenkins, RW Jenkins, Scott Rodig, Shohei Koyama, Shunsuke Kitajima, Thanh Uyen Barbie, Tian Tian, Timothy Hagan, Tran Thai, X Wu, Y Qiao, Yanan Kuang, Yanxi Zhang, Yu Imamura, Zhi Wei   +75 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Influence of polyamines of bacterial origin on the production of key cytokines in the culture of human mononuclear leukocytes

Медицинская иммунология, 2022
To date, participation of biogenic polyamines has been studied in details, with respect to regulation of microbial gene expression, interrelations between bacteria, development of their persistence state.
A. P. Godovalov, T. I. Karpunina
doaj   +1 more source

Enhanced Immunomodulation in Inflammatory Environments Favors Human Cardiac Mesenchymal Stromal-Like Cells for Allogeneic Cell Therapies [PDF]

, 2019
Rising numbers of patients with cardiovascular diseases and limited availability of donor hearts require new and improved therapy strategies. Human atrial appendage-derived cells (hAACs) are promising candidates for an allogeneic cell-based treatment. In
Diedrichs, Falk, Haag, Marion, Jürchott, Karsten, Seifert, Martina, Sittinger, Michael, Stolk, Meaghan   +5 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFNγ Regulation [PDF]

, 2015
peer-reviewedData Availability: The raw sequencing reads (FASTQ files) and sequence read counts mapped to UCSC hg19 for each of the 74 transcriptomes sequenced in this study have been deposited at Gene Expression Omnibus (GEO) accession GSE69549.This ...
Castro, Patricia Dominguez, Coleman, Ciara, Cormican, Paul, Mahmud, Nasir, McManus, Ross, Molloy, Ben, Quinn, Emma M, Trimble, Valerie   +7 more
core   +7 more sources

Phage therapy in antibiotic resistant pneumonia: immunomodulation or redistribution?

Медицинская иммунология, 2021
Our report concerns the observations made during the treatment of pneumonia with individually selected bacteriophages in HCAI patients on mechanical ventilation.
S. S. Bochkareva, I. M. Fedorova, O. N. Ershova, S. I. Koteleva, I. V. Kapustin, M. S. Blyakher, L. I. Novikova, A. V. Aleshkin, А. М. Vorobev   +8 more
doaj   +1 more source

Macrophage polarization impacts tunneling nanotube formation and intercellular organelle trafficking. [PDF]

, 2019
Tunneling nanotubes (TNTs) are cellular extensions enabling cytosol-to-cytosol intercellular interaction between numerous cell types including macrophages.
Cherqui, Stephanie, Goodman, Spencer, Khan, Meisha, Naphade, Swati, Sharma, Jay   +4 more
core   +1 more source