Results 51 to 60 of about 140,805 (301)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Immune response in atopic dermatitis: main pathogenetic mechanisms and stage-dependent correlations with age in regard to dermatological and non-dermatological systemic processes

Медицинская иммунология, 2021
Atopic dermatitis is one of the most common chronic inflammatory skin diseases caused by both terminal defects in keratinocyte differentiation, and pronounced type 2 immune responses.
M. B. Drozhdina, E. V. Suslova
doaj   +1 more source

KEGAGALAN KEHAMILAN AKIBAT INFEKSI Toxoplasma gondiiGALUR RH DIPICU OLEH OVERPRODUKSI INTERFERON GAMMA (IFNγ γγ γ)

Jurnal Kedokteran Brawijaya, 2013
It has been already known that transplacental infiltration of parasites occurred during Toxoplasma infection in pregnancy; but pregnancy failures may due to some other previous mechanisms. Eighty BALB/c female mice were monogamously mated than devided into three pairs of study groupsand a pair of control group.
openaire   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Porphyromonas, Treponema, and Mogibacterium promote IL8/IFNγ/TNFα-based pro-inflammation in patients with medication-related osteonecrosis of the jaw

Journal of Oral Microbiology, 2021
Objective: Refractory infection is an important factor affecting the progression of medication-related osteonecrosis of the jaw (MRONJ) from clinical stage I to stage II/III.
Qingxiang Li, Yinfei Pu, Han Lu, Ning Zhao, Yifei Wang, Yuxing Guo, Chuanbin Guo   +6 more
doaj   +1 more source

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source

Methamphetamine use and HSV-1 coinfection synergistically alter IFNα, IFNγ, and IL-29 expression in gingival crevicular fluid: implications for gingivitis pathogenesis

Инфекция и иммунитет
Background. Methamphetamine use compromises both innate and adaptive immune responses, substantially reducing the body’s ability to combat pathogens and preserve mucosal integrity.
N. A. Alsattar, Ghada I. Taha
doaj   +1 more source

The TreaT-Assay: A Novel Urine-Derived Donor Kidney Cell-Based Assay for Prediction of Kidney Transplantation Outcome [PDF]

, 2019
Donor-reactive immunity plays a major role in rejection after kidney transplantation, but analysis of donor-reactive T-cells is not applied routinely. However, it has been shown that this could help to identify patients at risk of acute rejection.
Babel, Nina, Choi, Mira, Kurtz, Andreas, Lachmann, Nils, Mueskes, Annemarie, Nickel, Peter, Reinke, Petra, Roch, Toralf, Rosiewicz, Kamil, Schmueck-Henneresse, Michael, Stein, Maik, Stervbo, Ulrik, Thieme, Constantin J., Wehler, Patrizia, Weist, Benjamin J. D., Westhoff, Timm H.   +15 more
core   +1 more source

Marked Long‐term Improvement in Lung Function in Melanoma Differentiation‐associated Protein 5 (MDA5) Antibody Positive Dermatomyositis Patients: Experience of a Single Center Longitudinal Cohort in North America

Arthritis Care &Research, Accepted Article.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation‐associated gene 5 antibody (MDA5 ab) associated dermatomyositis (DM). Methods Thirty patients with MDA5 ab DM were identified in a single center longitudinal cohort of 352 patients with ...
Jenice X Cheah, Sangmee S Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source

A targeted immunotherapy approach for HER2/neu transformed tumors by coupling an engineered effector domain with interferon-γ

OncoImmunology, 2018
Despite substantial clinical progress with targeted therapies, current antibody-based approaches have limited efficacy at controlling HER2/neu-positive breast cancers, especially in the absence of chemotherapies.
Hongtao Zhang, Lian Lam, Yasuhiro Nagai, Zhiqiang Zhu, Xi Chen, Mei Q. Ji, Mark I. Greene   +6 more
doaj   +1 more source