Results 61 to 70 of about 140,805 (301)

Type I/II interferon in HIV-1-infected patients: expression in gut mucosa and in peripheral blood mononuclear cells and its modification upon probiotic supplementation [PDF]

, 2018
Expression of type I and II interferon (IFN) was evaluated in gut-associated lymphoid tissue (GALT) and peripheral blood mononuclear cells (PBMCs) of HIV-1-positive patients on long-term, suppressive, antiretroviral therapy before and after probiotic ...
Antonelli, Guido, Brenchley, Jason M., Ceccarelli, Giancarlo, Corano Scheri, Giuseppe, D’Ettorre, Gabriella, Innocenti, Giuseppe Pietro, Pinacchio, Claudia, Santinelli, Letizia, Scagnolari, Carolina, Statzu, Maura, Vullo, Vincenzo   +10 more
core   +1 more source

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

LYG1 exerts antitumor function through promoting the activation, proliferation, and function of CD4+ T cells

OncoImmunology, 2017
Identification of novel stimulatory cytokines with antitumor function would have great value in tumor immunotherapy investigations. Here, we report LYG1 (Lysozyme G-like 1) identified through the strategy of Immunogenomics as a novel classical secretory ...
Huihui Liu, Yanfei Zhang, Zhengyang Liu, Pingzhang Wang, Xiaoning Mo, Weiwei Fu, Wanchang Liu, Yingying Cheng, Wenling Han   +8 more
doaj   +1 more source

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

Purification technology design, biochemical and immunological characteristics of the recombinant chimeric antigen for evaluation of T cell immunity against coronavirus infection

Медицинская иммунология
Diagnosis of specific T cell immunity to the antigenic determinants of SARS-CoV-2 in patients seems to be an increasingly important task due to accumulation of data about the role of T cell immune response in course of coronavirus infection and clearance
V. V. Kopat, A. A. Riabchenkova, E. L. Chirak, E. R. Chirak, A. I. Saenko, I. V. Kudryavtsev, A. S. Trulioff, T. V. Savin, E. V. Zueva, A. S. Simbirtsev, A. A. Totolyan, I. V. Dukhovlinov   +11 more
doaj   +1 more source

Tumor PD-L1 expression is correlated with increased TILs and poor prognosis in penile squamous cell carcinoma

OncoImmunology, 2017
Despite its rare incidence worldwide, penile squamous cell carcinoma (PeSCC) still presents with significant morbidity and mortality due to the limited treatment options for advanced patients, especially those in developing countries. The program death-1
Chuangzhong Deng, Zaishang Li, Shengjie Guo, Peng Chen, Xiaofeng Chen, Qianghua Zhou, Jieping Chen, Xingsu Yu, Xiaoliang Wu, Wenjuan Ma, Qiankun Xie, Yunlin Ye, Yonghong Li, Zike Qin, Zhuowei Liu, Ranyi Liu, Zhenfeng Zhang, Kai Yao, Hui Han, Fangjian Zhou   +19 more
doaj   +1 more source

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade [PDF]

, 2019
Melanoma is one of the most deadly and therapy-resistant cancers. Here we show that N6-methyladenosine (m6A) mRNA demethylation by fat mass and obesity-associated protein (FTO) increases melanoma growth and decreases response to anti-PD-1 blockade ...
Aplin, Andrew E., Cui, Yan-Hong, Deng, Yu, He, Chuan, He, Yu-Ying, Hwang, Seungmin, Lu, Zhike, Park, Gayoung, Shah, Palak, Wei, Jiangbo, Yang, Seungwon   +10 more
core   +1 more source

Immune-mediated loss of transgene expression from virally transduced brain cells is irreversible, mediated by IFNγ, perforin, and TNFα, and due to the elimination of transduced cells [PDF]

, 2012
The adaptive immune response to viral vectors reduces vector-mediated transgene expression from the brain. It is unknown, however, whether this loss is caused by functional downregulation of transgene expression or death of transduced cells.
Ahmed, Ali, Asadi-Moghaddam, Bantug, Barcia, Barcia, Barcia, Barcia, Barcia, Barcia, Bergmann, Byrnes, Byrnes, Carlos Barcia, Chen, Chiocca, Chunyan Liu, Conrady, Dewey, Diamond, Glass, Griffin, Griffin, Hausmann, Huse, Jeffrey M Zirger, Jiang, Jiang, Jiang, Josee Bergeron, Kanegae, Kurt M Kroeger, Lang, Lowenstein, Lowenstein, Maria G Castro, Mariana Puntel, McGavern, Mia Wibowo, Määttä, Niyati Bondale, O'Keefe, Parra, Paxinos, Pedro R Lowenstein, Pulkkanen, Puntel, Rall, Rameen Moridzadeh, Shi, Smith-Arica, Southgate, Southgate, Thomas, Thomas, Wang, Wilkinson, Williamson, Wirth, Yang, Zambrowicz   +60 more
core   +1 more source

Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes

Advanced Healthcare Materials, EarlyView.
A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu, Xi Rui Qiang Lu, Seoyoung Jeong, Douglas H. Wu, Rodrigo A. Somoza, Parameswaran Ramakrishnan, Samuel E. Senyo   +6 more
wiley   +1 more source

Evaluation of the pharmacokinetics of an experimental combined form of IFNα and IFNγ for intranasal use

Медицинская иммунология
Polypous rhinosinusitis is a chronic inflammatory disease of the nasal mucosa and paranasal sinuses. Recombinant interferon has antiproliferative activity and corrects the deficiency of endogenous regulatory molecules, which allows us to consider this ...
E. V. Kravchenko, E. V. Bezrukova, E. V. Vorobeychikov, N. V. Skvortsov   +3 more
doaj   +1 more source