Results 71 to 80 of about 140,805 (301)

CD4+ Th1 to the rescue in HER-2+ breast cancer

OncoImmunology, 2019
HER2 overexpression leads to downregulation of MHC class-I. CD4+ Th1 cytokines, IFNγ and TNFα, and monoclonal antibodies, trastuzumab and pertuzumab, restore MHC class-I expression, and enable CD8+ recognition and cytolysis.
Lea Lowenfeld, Shuwen Xu, Brian J. Czerniecki   +2 more
doaj   +1 more source

IL‐2 Free Expansion of T Cells with Immunofilaments

Advanced Healthcare Materials, EarlyView.
Ratio and density of stimulatory αCD3 and αCD28 mAb on immunofilaments (IF) influence T cell expansion, cytokine production, and effector phenotype. Moreover, IL‐2 supplementation is not necessary with optimal performing IFs, which leads to simpler culture conditions, and negative side effects of IL‐2 supplementation are reduced.
Marjolein Schluck, Lea Weiss, René Classens, Carl G. Figdor, Roel Hammink   +4 more
wiley   +1 more source

Cytokine profile in the liver during its diffuse damage and Heptor introduction

Медицинская иммунология
Chronic diffuse liver diseases are among urgent problems in the modern world. Exposure to tobacco smoke was used as a model to reproduce liver pathology.
O. V. Alpidovskaya
doaj   +1 more source

Local cytokine transcription in naïve and previously infected sheep and lambs following challenge with Teladorsagia circumcincta [PDF]

, 2014
<b>Background</b><p></p> The abomasal helminth Teladorsagia circumcincta is one of the most economically important parasites affecting sheep in temperate regions.
Craig, Nicola M, Knight, Pamela A, Morrison, Ivan W, Pate, Judith A, Smith, David W   +4 more
core   +3 more sources

Automating Vascular Biology: An End‐to‐End Automated Workflow for High‐Throughput Blood Vessel‐on‐a‐Chip Production and Multi‐Site Validation

Advanced Healthcare Materials, EarlyView.
AngioPlate384 is a 384‐well open‐top platform that automates production of more than 100 miniaturized, perfusable blood vessels embedded in hydrogel and supported by stromal cells. Stromal‐endothelial co‐culture strengthens blood vessel barrier function and yields responses useful for translational planning. Scalable and automation‐ready, it suits drug
Dawn S. Y. Lin, Hanieh Mohammad Hashemi, Kimia Asadi Jozani, Anushree Chakravarty, Sonya Kouthouridis, Jessica Bonanno, Nicky Anvari, Shravanthi Rajasekar, Feng Zhang, Richard Y. Cheng, Narendra Kumar Singh, Luis Miguel Medina, Marc Durante, Yufang He, Boyang Zhang   +14 more
wiley   +1 more source

Determination of t cell immune response to SARS-CoV-2 coronavirus based on induced γ-interferon production by specific T cells upon their stimulation by viral antigen

Медицинская иммунология
The aim of this work was to study the capacity of human T cells immune for SARS-CoV-2, to produce IFNγ, a marker of T cell immunity, in response to stimulation by a peptide pool in whole blood.
B. S. Cherepovich, A. M. Kudryashova, L. L. Pankratieva, A. V. Bogolyubova, V. A. Manuilov, V. A. Gushchin, A. A. Pochtovyi, O. V. Borisova, O. A. Svitich   +8 more
doaj   +1 more source

Supplementary Figure S7 from HLA Class II Loss and JAK1/2 Deficiency Coevolve in Melanoma Leading to CD4 T-cell and IFNγ Cross-Resistance [PDF]

, 2023
Simone Stupia, Christina Heeke, Alicia Brüggemann, Anne Zaremba, Beatrice Thier, Julia Kretz, Antje Sucker, Manuel Philip, Gennadiy Zelinskyy, Soldano Ferrone, Alexander Roesch, Susanne Horn, Eva Hadaschik, Dirk Schadendorf, Mirko Trilling, Ulf Dittmer, Klaus Griewank, Fang Zhao, Annette Paschen   +18 more
openalex   +1 more source

In Situ Synthesis of Covalent Organic Frameworks Inside Cells for Triggering Ferroptosis and Immunotherapy

Advanced Materials, EarlyView.
We have developed an intracellular crystalline polymerization strategy involving acid‐catalyzed imine condensation to synthesize COFs in lysosomes. The generation of COFs in lysosomes damages their integrity, activates iron species, and induces immunogenic ferroptosis, thereby enhancing antitumor immunotherapy.
Qun Guan, Le‐Le Zhou, Zhiqing Yang, Yan‐An Li, Leyong Wang, Ruibing Wang   +5 more
wiley   +1 more source

NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance [PDF]

, 2019
Lack of proper innate sensing inside tumor microenvironment (TME) limits T cell-targeted immunotherapy. NAD(P)H:quinone oxidoreductase 1 (NQO1) is highly enriched in multiple tumor types and has emerged as a promising target for direct tumor-killing ...
Boothman, David A., Fu, Yang-Xin, Han, Chuanhui, Huang, Xiumei, Jiang, Lingxiang, Li, Xiaoguang, Liu, Zhida, Qiao, Jian, Shen, Aijun, Wang, Yang, Zhang, Anli   +10 more
core   +1 more source

Remote‐Controllable Immune‐Priming Spot Formation Via Nanocomplexed Hydrogel‐Assisted Histotripsy: Immunoasis

Advanced Materials, EarlyView.
A novel immunotherapeutic strategy combines injectable, adjuvant‐loaded hydrogels with externally controlled histotripsy to create immune‐priming sites within tumors. This approach generates millimeter‐sized immune‐activated lesions with flexible, patient‐tailored treatment scheduling, enabling precise immune activation through tumor ablation‐mediated ...
Sung Hoon Kim, Wonseok Choi, Yurim Kim, Hyeongmin Kim, Gu Won Jeong, Hyewon Park, Inchan Youn, Yoon Park, Sungmin Han, Young‐Min Kim   +9 more
wiley   +1 more source