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Journal of Cell Science, 2021
ABSTRACT Flagellar assembly depends on intraflagellar transport (IFT), a bidirectional motility of protein carriers, the IFT trains. The trains are periodic assemblies of IFT-A and IFT-B subcomplexes and the motors kinesin-2 and IFT dynein.
Jenna L. Wingfield +7 more
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ABSTRACT Flagellar assembly depends on intraflagellar transport (IFT), a bidirectional motility of protein carriers, the IFT trains. The trains are periodic assemblies of IFT-A and IFT-B subcomplexes and the motors kinesin-2 and IFT dynein.
Jenna L. Wingfield +7 more
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IFT cargo and motors associate sequentially with IFT trains to enter cilia
2023Summary Intraflagellar transport (IFT) orchestrates entry of proteins into primary cilia. At the ciliary base, assembled IFT trains, driven by kinesin-2 motors, can transport cargo proteins into the cilium, across the crowded transition zone (TZ). How trains assemble at the base and how proteins associate with them is
Aniruddha Mitra +2 more
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Electron Tomography of IFT Particles
2013Cilia and flagella play very important roles in eukaryotic cells, ranging from cell motility to chemo- and mechanosensation with active involvement in embryonic development and control of cell division. Cilia and flagella are highly dynamic organelles undergoing constant turnover at their tip, where multiprotein precursors synthesized in the cell ...
Pigino, G. +5 more
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Trends in Cell Biology, 2000
We see the world through cilia. The outer segments of rods and cones are highly specialized sensory cilia, and the entire photosensing machinery including opsin is located in the outer segment and must be transported through a narrow connecting cilium that separates the outer segment from the cell body. But what motors drive this transport?
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We see the world through cilia. The outer segments of rods and cones are highly specialized sensory cilia, and the entire photosensing machinery including opsin is located in the outer segment and must be transported through a narrow connecting cilium that separates the outer segment from the cell body. But what motors drive this transport?
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Protoplasma, 2011
Mediating the transport of flagellar precursors and removal of turnover products, intraflagellar transport (IFT) is required for flagella assembly and maintenance. The IFT apparatus is composed of the anterograde IFT motor kinesin II, the retrograde IFT motor IFT-dynein, and IFT particles containing two complexes, A and B.
Hongmin Qin
exaly +3 more sources
Mediating the transport of flagellar precursors and removal of turnover products, intraflagellar transport (IFT) is required for flagella assembly and maintenance. The IFT apparatus is composed of the anterograde IFT motor kinesin II, the retrograde IFT motor IFT-dynein, and IFT particles containing two complexes, A and B.
Hongmin Qin
exaly +3 more sources
Science Signaling, 2015
The intraflagellar transport complex A (IFT-A) functions in the cytosol to promote Wnt–β-catenin signaling.
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The intraflagellar transport complex A (IFT-A) functions in the cytosol to promote Wnt–β-catenin signaling.
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Sorting at ciliary base and ciliary entry of BBSome, IFT-B and IFT-A
Summary/Abstract Anterograde intraflagellar transport (IFT) trains, composed of IFT-B, IFT-A and BBSome subcomplexes, are responsible for transporting ciliary proteins into the cilium. How IFT subcomplexes reach the ciliary base and assemble into IFT trains is poorly understood.Aniruddha Mitra +3 more
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