Academic competition-based learning cultivates scientific literacy to promote professional competitiveness in medical undergraduates [PDF]
Frontiers in Public HealthBackgroundContemporary healthcare requires medical professionals with advanced scientific literacy. Current undergraduate medical curricula may not consistently develop this critical skillset.
Yan Ruan +12 more
doaj +2 more sources
An integrated engineering worldview of synthetic biology education through the lens of webinar based pedagogy [PDF]
Frontiers in Bioengineering and BiotechnologySynthetic biology is an interdisciplinary field that brings together engineering and biology concepts alongside the arts and social sciences to develop solutions to pressing problems in our world.
Iain George +9 more
doaj +2 more sources
A synthetic biology toolkit for rationally designing genetic circuits in Acinetobacter baumannii [PDF]
Frontiers in Systems BiologyIntroductionAntimicrobial resistance (AMR) poses a severe global health threat, with Acinetobacter baumannii among the critical AMR priorities highlighted by World Health Organization (WHO).
Sara Letrari +36 more
doaj +2 more sources
Protein engineering in the computational age: An open source framework for exploring mutational landscapes in silico [PDF]
Engineering Biology, 2023 The field of protein engineering has seen tremendous expansion in the last decade, with researchers developing novel proteins with specialised functionalities for a range of uses, from drug discovery to industrial biotechnology.
Shirin Bamezai +6 more
doaj +2 more sources
Towards effective cystic fibrosis gene therapy by optimizing prime editing and pulmonary-targeted LNPs [PDF]
Frontiers in Systems BiologyCystic fibrosis (CF) is the most prevalent inherited disease. Inactivating mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene lead to the accumulation of viscous mucus and subsequent respiratory complications.
Kaya Sophie Lange +24 more
doaj +2 more sources
Systematic Metabolic Engineering and Model‐Guided Optimization for High‐Level Production of L‐Theanine from Xylose in Escherichia coli [PDF]
Advanced Science, Volume 13, Issue 17, 23 March 2026.This study is pioneering in constructing the shortest known synthetic pathway for L‐theanine production from xylose within E coli. Through comprehensive metabolic engineering strategies, our engineered strain achieved the highest reported L‐theanine titer from xylose, with a titer of 95.42 g/L, and a yield of 0.55 g/g.
Haolin Han +5 more
wiley +2 more sources
Synthetic biology in Mexico: Brief history, current landscape, and perspectives towards a bio‐based economy [PDF]
Engineering BiologySynthetic biology (SynBio) makes biology easier by leveraging engineering principles and other disciplines to design and construct biological systems with novel or enhanced functions. SynBio has led to the development of more sustainable biotechnological
Uriel E. Barboza‐Pérez +2 more
doaj +2 more sources
Engineering of High‐Yield Recombinant Adeno‐Associated Virus Producer Plasmids [PDF]
Biotechnology Journal, Volume 21, Issue 1, January 2026.Graphical Abstract and Lay Summary Recombinant adeno‐associated viruses (AAV) are important in gene therapy but their production may be impaired by non‐optimized gene design. In this study, the authors demonstrate that production was best when the AAV replicase gene was in a wild‐type configuration while the complexity of other genetic elements could ...
Marco T. Radukic +10 more
wiley +2 more sources
Identification of Opportunistic Pathogens on the Skin of Salamanders for Use as Molecular Targets of a De Novo Design of Multitarget Anti‐Bd Proteins [PDF]
International Journal of Microbiology, Volume 2026, Issue 1, 2026.Objectives Chytridiomycosis, caused by Batrachochytrium dendrobatidis (Bd), is one of the most devastating fungal diseases affecting amphibians worldwide. This study aimed to design an in silico protein‐based treatment targeting Bd and pathogenic bacteria associated with the skin microbiota of four Bd‐infected salamander species. Methods Pathogenic and
Jimena Ramírez-Villarreal +2 more
wiley +2 more sources
Toehold switch based biosensors for sensing the highly trafficked rosewood Dalbergia maritima
Synthetic and Systems Biotechnology, 2022 Nucleic acid sensing is a 3 decades old but still challenging area of application for different biological sub-domains, from pathogen detection to single cell transcriptomics analysis.
Paul Soudier +15 more
doaj +1 more source