Results 131 to 140 of about 18,629 (186)

Disorders of IGFs and IGF-1R signaling pathways

Molecular and Cellular Endocrinology, 2020
The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that regulate multiple physiological processes, including mammalian development, metabolism and growth, through the type 1 IGF receptor (IGF-1R). The growth hormone (GH)-IGF-I axis is the major regulator of longitudinal growth.
Jan M Wit, Briony Forbes
exaly   +4 more sources

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Transactivation of the IGF-1R by aldosterone

American Journal of Physiology-Renal Physiology, 2007
Activation of epithelial sodium channels (ENaC) by aldosterone, insulin, or insulin-like growth factor-1 (IGF-1) in renal epithelial cells (including the Xenopus laevis renal cell line A6) appears to share some common signaling elements subsequent to the initial insulin or IGF-1 receptor activation.
Jennifer L, Holzman, Lian, Liu, Billie Jeanne, Duke, Alexandra E, Kemendy, Douglas C, Eaton   +4 more
openaire   +2 more sources

IGF-1R tyrosine kinase expression and dependency in clones of IGF-1R knockout cells (R−)

Biochemical and Biophysical Research Communications, 2006
Insulin-like growth factor 1 receptor (IGF-1R) plays many crucial roles in cancer, like anti-apoptotic activity and necessity for transformation. IGF-1R knockout cells (R-) represent a useful tool for molecular mapping of biological properties of the receptor.
Linda, Rosengren, Daiana, Vasilcanu, Radu, Vasilcanu, Sandra, Fickenscher, Bita, Sehat, Nathalia, Natalishvili, Sean, Naughton, Shucheng, Yin, Ada, Girnita, Leonard, Girnita, Magnus, Axelson, Olle, Larsson   +11 more
openaire   +2 more sources

Abstract 1631: Tumorigenicity of IGF-1R and IR: Rationale for co-targeting IGF-1R and IR in cancer

Cancer Research, 2011
Abstract The Type 1 insulin-like growth factor receptor (IGF-1R) is a well established mediator of tumor cell proliferation and survival. IGF-1R is required for cellular transformation by a number of oncogenes including Ras, and expression of IGF-1R can promote tumor formation in vivo.
Lorena Lerner, Qing Liu, Nianjun Tao, John Yang, Eric Brown, Susan Koujak, Brian Krieger, Lu Huang, Maryland Rosenfeld-Franklin, Mark Miglarese, Jonathan Pachter, Murray O. Robinson, M. Isabel Chiu, David Epstein, Elizabeth Buck   +14 more
openaire   +1 more source

IGF-1R mRNA expression is increased in obese children

Growth Hormone & IGF Research, 2018
Obese children are often taller than age-matched subjects. Reports on GH and IGF-I levels in obese individuals are controversial, with normal and reduced GH-IGF-I levels having been reported in this group of patients. Thus, the aim of this study was to analyse insulin-like growth factor type 1 receptor (IGF-IR) mRNA expression in obese children.Forty ...
Rafaela Cristina, Ricco, Rubens Garcia, Ricco, Mariangela Carletti, Queluz, Mariana Teresa Sarti, de Paula, Patricia Volpon, Atique, Rodrigo José, Custódio, Hugo, Tourinho Filho, Raphael, Del Roio Liberatori, Carlos Eduardo, Martinelli   +8 more
openaire   +2 more sources

Advances of IGF-1R inhibitors in Graves’ ophthalmopathy

International Ophthalmology
Graves' ophthalmopathy is the most common extra-thyroidal organ manifestation of Graves' disease. The mainstay of clinical treatment is glucocorticoids; however, side effects and relapse are common problems, and current treatment options cannot alter the disease progression.
Meilan, Wang, Lian, Liu
openaire   +2 more sources