Therapeutic Targeting of the IGF Axis
Cells, 2019 The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and development, and when deregulated makes an important contribution to disease.
Valentine Macaulay
exaly +3 more sources
Regulation of human fibroblast insulin-like growth factor (IGF)-binding proteins by IGF-1 and cytokines, mechanisms of action and effects upon IGF bioactivity [PDF]
, 1995 PhDThe insulin-like growth factors, IGF-I and IGF-II, are ubiquitous polypeptide molecules that have mitogenic and metabolic actions in a wide variety of cell types, and consequently play a major role in mammalian growth and development.
Yateman, Martin Edward
core +4 more sources
Un viaggio nella Gestalt: come cambia il benessere durante il percorso gestaltico
Phenomena Journal, 2023 Questo lavoro riporta alcuni risultati preliminari di un progetto di ricerca volto a indagare il rapporto tra il benessere percepito e il lavoro personale in psicoterapia della Gestalt.
Stefano Roti 1 , Francesca Berti 1 , Nino Geniola2 , Susanna Zajotti 1 , Giulia Calvaresi 1 , Matteo Defraia1 , Alessandro Cini 1
doaj +1 more source
Cumulative mutagenesis of the basic residues in the 201-218 region of insulin-like growth factor (IGF)-binding protein-5 results in progressive loss of both IGF-I binding and inhibition of IGF-I biological action [PDF]
, 2005 We have reported previously that mutation of two conserved nonbasic amino acids (G203 and Q209) within the highly basic 201–218 region in the C-terminal domain of IGF-binding protein-5 (IGFBP-5) decreases binding to IGFs.
Clegg, R.A. +9 more
core +4 more sources
The GH-IGF-I axis and breast cancer [PDF]
, 2012 MD (Res)Breast cancer remains one of the most common causes of death amongst women today. Worldwide approximately 1.3 million women are diagnosed as having breast cancer every year.
Laban, Christiana
core +4 more sources
Research progress of IGF‐1 and cerebral ischemia
Ibrain, 2021 Cerebral ischemic disease is a group of diseases that cause insufficient blood supply to the cerebrum, cerebellum or brain stem for different reasons, resulting in corresponding nervous system symptoms.
Shun‐Lian Li +3 more
doaj +1 more source
The IGF-1 Signaling Pathway in Viral Infections
Viruses, 2021 Insulin-like growth factor-1 (IGF-1) and the IGF-1 receptor (IGF-1R) belong to the insulin-like growth factor family, and IGF-1 activates intracellular signaling pathways by binding specifically to IGF-1R.
Agata Józefiak +3 more
doaj +1 more source
New insights on the cardiovascular effects of IGF-1
Frontiers in Endocrinology, 2023 IntroductionCardiovascular (CV) disorders are steadily increasing, making them the world’s most prevalent health issue. New research highlights the importance of insulin-like growth factor 1 (IGF-1) for maintaining CV healthMethodsWe searched PubMed and ...
Mirjana Macvanin +7 more
doaj +1 more source
Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets
Frontiers in Oncology, 2021 AimInsulin-like growth factor-1 receptor (IGF-1R) is one of the main members of the tyrosine protein kinase receptor family. This receptor binds insulin-like growth factor-1 (IGF-1) with a high affinity. IGF-1 is a member of a family of proteins involved
Yinqi Zhang +17 more
doaj +1 more source
Elevated serum concentrations of IGF-1 and IGF-1R in patients with thyroid cancers
Biomedical Papers, 2020 Background: The rising incidence of thyroid cancer observed in the last few decades requires an improvement in diagnostic tools and management techniques for patients with thyroid nodules. Aims: The aim of this study was to assess serum concentrations of
Hanna Lawnicka +7 more
doaj +1 more source