Results 1 to 10 of about 107,691,036 (255)

Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody

Haematologica, 2010
Background Alterations in the PI3K/Akt pathway are found in a wide range of cancers and the development of PI3K inhibitors represents a promising approach to cancer therapy.
Nicolas Chapuis, Jérôme Tamburini, Pascale Cornillet-Lefebvre, Lucile Gillot, Valérie Bardet, Lise Willems, Sophie Park, Alexa S Green, Norbert Ifrah, François Dreyfus, Patrick Mayeux, Catherine Lacombe, Didier Bouscary   +12 more
doaj   +1 more source

Insulin-like growth factor family and prostate cancer: new insights and emerging opportunities

Frontiers in Endocrinology
Prostate cancer is the second most commonly diagnosed cancer in men. The mammalian insulin-like growth factor (IGF) family is made up of three ligands (IGF-I, IGF-II, and insulin), three receptors (IGF-I receptor (IGF-1R), insulin receptor (IR), and IGF ...
Noha M. Elemam, Noha M. Elemam, Hassan Youssef Hotait, Mohamed A. Saleh, Mohamed A. Saleh, Mohamed A. Saleh, Waseem El-Huneidi, Waseem El-Huneidi, Iman M. Talaat, Iman M. Talaat, Iman M. Talaat   +10 more
doaj   +1 more source

IGF-binding protein 2 (IGFBP2) – oncogene or tumour suppressor?

Frontiers in Endocrinology, 2015
The role of Insulin-like growth factor binding protein 2 (IGFBP2) in cancer is unclear. In general IGFBP2 is considered to be oncogenic and its expression is often observed to be elevated in cancer.
Adam ePickard, Dennis J McCance, Dennis J McCance   +2 more
doaj   +1 more source

Serum insulin-like growth factor-1 as a potential marker for MDD diagnosis, its clinical characteristics, and treatment efficacy validation: data from an open-label vortioxetine study

BMC Psychiatry, 2020
Background IGF-1 is an essential neurotrophin produced peripherally and in the brain. Impairments in the brain IGF-1 concentrations might be responsible for some aspects of major depressive disorder (MDD) pathogenesis, whereas peripheral IGF-1 could have
Oleg A. Levada, Alexandra S. Troyan, Irina Y. Pinchuk   +2 more
doaj   +1 more source

Neuroprotection of IGF-1 in neonatal hypoxic-ischemic brain injury through downregulation of FoXO3a-PUMA pathway

Frontiers in Cellular Neuroscience
Insulin-like growth factor-1 (IGF-1) is a single chain polypeptide hormone that plays an essential role in intrauterine and postnatal growth. Recent studies suggest that IGF-1 and its receptor IGF-1R are involved in the pathogenesis of neurological ...
Yanli Tang, Rui Zhong, Jiayi Liang, Shuang Liu, Wanxia Liu, Tao Liu, Baohong Yuan, Baohong Yuan, Mengya Jiao, Mengya Jiao, Mengya Jiao, Hui Yin, Hui Yin   +12 more
doaj   +1 more source

Anabolic effects of IGF-1 signaling on the skeleton

Frontiers in Endocrinology, 2013
This review focuses on the anabolic effects of IGF-1 signaling on the skeleton, emphasizing the requirement for IGF-1 signaling in normal bone formation and remodeling.
Candice G. T Tahimic, Candice G. T Tahimic, Yongmei eWang, Yongmei eWang, Daniel D. Bikle, Daniel D. Bikle   +5 more
doaj   +1 more source

IGF-IR internalizes with Caveolin-1 and PTRF/Cavin in HaCat cells. [PDF]

PLoS ONE, 2010
BACKGROUND:Insulin-like growth factor-I receptor (IGF-IR) is a tyrosine kinase receptor (RTK) associated with caveolae, invaginations of the plasma membrane that regulate vesicular transport, endocytosis and intracellular signaling.
Barbara Salani, Mario Passalacqua, Sara Maffioli, Lucia Briatore, Meriem Hamoudane, Paola Contini, Renzo Cordera, Davide Maggi   +7 more
doaj   +1 more source

IGF-1 impacts neocortical interneuron connectivity in epileptic spasm generation and resolution

Neurotherapeutics
Little is known about the mechanisms that generate epileptic spasms following perinatal brain injury. Recent studies have implicated reduced levels of Insulin-like Growth Factor 1 (IGF-1) in these patients’ brains.
Carlos J. Ballester-Rosado, John T. Le, Trang T. Lam, Anne E. Anderson, James D. Frost, Jr., John W. Swann   +5 more
doaj   +1 more source

Avaliação plasmática de igf-1 no prolactinoma IGF-1 plasma levels evaluation in prolactinoma

Arquivos de Neuro-Psiquiatria, 2006
Prolactinomas são os tumores hipofisários mais comuns, podendo co-secretar GH (hormônio do crescimento). IGF-1 (fator de crescimento insulina-símile-1) é o principal responsável pelas ações do GH e parâmetro diagnóstico de acromegalia.
Daniela Zylberberg, Erika C.O. Naliato, Alair Sarmet, Eduardo Sato, Fernando S.R. Costa, Alice H.D. Violante   +5 more
doaj   +1 more source

Insulin-like Growth Factor 1 gene polymorphism and breast cancer risk

Anais da Academia Brasileira de Ciências
Insulin-like Growth Factor-1 (IGF-1) gene polymorphism has been associated with an increased risk for breast cancer. IGF-1 is a key regulator of proliferation, cell differentiation and apoptosis.
DANYLO R. COSTA-SILVA, MARIA DA CONCEIÇÃO BARROS-OLIVEIRA, RAFAEL S. BORGES, CLÉCITON B. TAVARES, UMBELINA S. BORGES, FRANCISCO A. ALVES-RIBEIRO, VLADIMIR C. SILVA, BENEDITO B. DA SILVA   +7 more
doaj   +1 more source