Results 1 to 10 of about 145,691 (215)
IGF-1 and Survival in ESRD [PDF]
Clinical Journal of the American Society of Nephrology, 2014 Summary Background and objectives IGF-1 deficiency links to malnutrition in CKD patients; however, it is not clear to what extent it associates with survival among these patients. Design, setting, participants, & measurements Serum IGF-1 and other biochemical, clinical
Ting, Jia +6 more
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Gut Microbiota and IGF-1 [PDF]
Calcified Tissue International, 2018 Microbiota and their hosts have coevolved for millions of years. Microbiota are not only critical for optimal development of the host under normal physiological growth, but also important to ensure proper host development during nutrient scarcity or disease conditions.
Jing Yan, Julia F. Charles
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Aging, Atherosclerosis, and IGF-1 [PDF]
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2012 Insulin-like growth factor 1 (IGF-1) is an endocrine and autocrine/paracrine growth factor that circulates at high levels in the plasma and is expressed in most cell types. IGF-1 has major effects on development, cell growth and differentiation, and tissue repair. Recent evidence indicates that IGF-1 reduces atherosclerosis burden and improves features
Yusuke, Higashi +4 more
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IGF-1 and cardiovascular disease [PDF]
Growth Hormone & IGF Research, 2019 Atherosclerosis is an inflammatory arterial pathogenic condition, which leads to ischemic cardiovascular diseases, such as coronary artery disease and myocardial infarction, stroke, and peripheral arterial disease. Atherosclerosis is a multifactorial disorder and its pathophysiology is highly complex.
Yusuke, Higashi +3 more
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Regulation of IGF -1 signaling by microRNAs [PDF]
Frontiers in Genetics, 2015 The insulin-like growth factor 1 (IGF-1) signaling pathway regulates critical biological processes including development, homeostasis, and aging. Dysregulation of this pathway has been implicated in a myriad of diseases such as cancers, neurodegenerative diseases, and metabolic disorders, making the IGF-1 signaling pathway a prime target to develop ...
Hwa Jin eJung +3 more
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IGF-1 receptor cleavage in hypertension [PDF]
Hypertension Research, 2018 Increased protease activity causes receptor dysfunction due to extracellular cleavage of different membrane receptors in hypertension. The vasodilatory effects of insulin-like growth factor-1 (IGF-1) are decreased in hypertension. Therefore, in the present study the association of an enhanced protease activity and IGF-1 receptor cleavage was ...
Cirrik, Selma +1 more
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The GH-IGF-1 Axis in Circadian Rhythm [PDF]
Frontiers in Molecular Neuroscience, 2021 Organisms have developed common behavioral and physiological adaptations to the influence of the day/night cycle. The CLOCK system forms an internal circadian rhythm in the suprachiasmatic nucleus (SCN) during light/dark input. The SCN may synchronize the growth hormone (GH) secretion rhythm with the dimming cycle through somatostatin neurons, and the ...
Wang, W +5 more
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Studies on Insulin/IGF‐1 Hybrid and IGF‐1 Growth‐Promoting Functional Region [PDF]
IUBMB Life, 2000 AbstractSingle‐chain insulin/IGF‐1 hybrid‐[Ins/IGF‐1(C)], single‐chain porcine insulin precursor‐(PIP), and B10Asp PIP were prepared by protein engineering. Their growth‐promoting activities in mouse breast cancer cell line GR2H6 are 10, 0.2, and 2 times that of insulin, respectively, and 29%, 0.6%, and 6% of that of IGF‐1, indicating that the C domain
P, Wang, R R, Cai, Y M, Feng, Y S, Zhang
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Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth [PDF]
Diabetes, 2008 OBJECTIVE—IGF-1 and the IGF-1 receptor (IGF-1R) have been implicated in the regulation of adipocyte differentiation and lipid accumulation in vitro. RESEARCH DESIGN AND METHODS—To investigate the role of IGF-1 receptor in vivo, we have inactivated the Igf-1r gene in adipose tissue (IGF-1RaP2Cre mice) using conditional gene targeting ...
Klöting, Nora +7 more
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IGF-1, oxidative stress and atheroprotection [PDF]
Trends in Endocrinology & Metabolism, 2010 Atherosclerosis is a chronic inflammatory disease in which early endothelial dysfunction and subintimal modified lipoprotein deposition progress to complex, advanced lesions that are predisposed to erosion, rupture and thrombosis. Oxidative stress plays a crucial role not only in initial lesion formation but also in lesion progression and ...
Yusuke, Higashi +4 more
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