Scientific Reports, 2022 Insulin like growth factor-1 (IGF-1) plays important roles in metabolic functions, especially in adulthood. Additionally, obese subjects are reportedly predisposed to having low absolute IGF-1 levels.
Haremaru Kubo +11 more
doaj +1 more source
IGF-1 Regulates the extracellular level of active MMP-2 and promotes Müller glial cell motility [PDF]
, 2015 In ischemic proliferative retinopathies, Müller glial cells (MGCs) acquire migratory abilities. However, the mechanisms that regulate this migration remain poorly understood.
Chiabrando, Gustavo Alberto +4 more
core +1 more source
Defects in mitophagy promote redox‐driven metabolic syndrome in the absence of TP53INP1
EMBO Molecular Medicine, 2015 The metabolic syndrome covers metabolic abnormalities including obesity and type 2 diabetes (T2D). T2D is characterized by insulin resistance resulting from both environmental and genetic factors.
Marion Seillier +21 more
doaj +1 more source
Effects of In Ovo Vitamin D3 Injection on Subsequent Growth of Broilers
The Journal of Poultry Science, 2019 This study was conducted to investigate the influence of in ovo vitamin D3 (Vit D3) administration on growth of broiler chickens when Vit D3 was dissolved in soybean oil.
Takehiko Hayakawa +2 more
doaj +1 more source
IGF-1 receptor cleavage in hypertension [PDF]
Hypertension Research, 2018 Increased protease activity causes receptor dysfunction due to extracellular cleavage of different membrane receptors in hypertension. The vasodilatory effects of insulin-like growth factor-1 (IGF-1) are decreased in hypertension. Therefore, in the present study the association of an enhanced protease activity and IGF-1 receptor cleavage was ...
Cirrik, Selma +1 more
openaire +5 more sources
The relationship between the insulin-like growth factor-1 axis, weight loss, an inflammation-based score and survival in patients with inoperable non-small cell lung cancer [PDF]
, 2010 <b>Background & aims:</b> The involvement of a systemic inflammatory response, as evidenced by the Glasgow Prognostic Score (GPS), is associated with weight loss and poor outcome in patients with non-small cell lung cancer.
Forrest, L.M. +3 more
core +1 more source
Insulin-like Growth Factor-1 (IGF-1) Related Drugs in Pain Management
Pharmaceuticals, 2023 Objective. The aim of this review is to explore the role of IGF-1 and IGF-1R inhibitors in pain-related conditions and assess the effectiveness of IGF-1-related drugs in pain management.
Seokhyun Jin, Jianguo Cheng
doaj +1 more source
Poultry Science, 2022 : We investigated the expression of insulin-like growth factor 1 (IGF-1) and IGF-1 type 1 receptor (IGF-1R) in skeletal muscle fiber types in chickens with hepatic fibrosis induced by bile duct ligation (BDL).
J. Nagasao +11 more
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Studies on Insulin/IGF‐1 Hybrid and IGF‐1 Growth‐Promoting Functional Region [PDF]
IUBMB Life, 2000 AbstractSingle‐chain insulin/IGF‐1 hybrid‐[Ins/IGF‐1(C)], single‐chain porcine insulin precursor‐(PIP), and B10Asp PIP were prepared by protein engineering. Their growth‐promoting activities in mouse breast cancer cell line GR2H6 are 10, 0.2, and 2 times that of insulin, respectively, and 29%, 0.6%, and 6% of that of IGF‐1, indicating that the C domain
P, Wang, R R, Cai, Y M, Feng, Y S, Zhang
openaire +2 more sources
Doxorubicin impairs the insulin-like growth factor-1 system and causes insulin-like growth factor-1 resistance in cardiomyocytes. [PDF]
PLoS ONE, 2015 Insulin-like growth factor-1 (IGF-1) promotes the survival of cardiomyocytes by activating type 1 IGF receptor (IGF-1R). Within the myocardium, IGF-1 action is modulated by IGF binding protein-3 (IGFBP-3), which sequesters IGF-1 away from IGF-1R.
Patrizia Fabbi +11 more
doaj +1 more source