Results 1 to 10 of about 18,579 (139)

Loss of IGF-1R impairs DNA-PKcs recruitment to chromatin leading to defective end-joining. [PDF]

Mol Oncol
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Ellis MO, Mills JV, Niedzwiedz W, Macaulay VM.   +3 more
europepmc   +2 more sources

Drugging IGF-1R in cancer: New insights and emerging opportunities

Genes and Diseases, 2023
The insulin-like growth factor (IGF) axis plays important roles in cancer development and metastasis. The type 1 IGF receptor (IGF-1R) is a key member in the IGF axis and has long been recognized for its oncogenic role in multiple cancer lineages.
Lydia Wai Ting Cheung, Víctor Chun Yin Mak   +1 more
exaly   +3 more sources

IGF1/IGF-1R promotes hepatocellular carcinoma progression by activating the Akt/GSK-3β pathway. [PDF]

PLoS ONE
The incidence of hepatocellular carcinoma (HCC) is increasing each year, with challenges such as increasing drug resistance and a high post-treatment recurrence rate. Therefore, investigating the novel pathogenic mechanisms is warranted.
Jiaojiao Liang, Xueyi Song, Yang Liu, Guoyu Yang, Bairu Zhu, Xiaolong Tang   +5 more
doaj   +2 more sources

Detection of Genome‐Wide IGF‐1R Recruitment to Enhancer and Promoter Regions of Chromatin in Clinical Prostate Cancers [PDF]

Cancer Medicine
Introduction Nuclear insulin‐like growth factor‐1 receptor (IGF‐1R) undergoes IGF‐induced recruitment to cancer cell chromatin in vitro and associates with advanced prostate cancer (PCa) stage in clinical tissue, prompting this investigation of IGF‐1R ...
Jack V. Mills, Avigail Taylor, Reema Singh, Jinseon Kim, Simon Engledow, Richard Colling, Clare Verrill, Ian G. Mills, Valentine M. Macaulay   +8 more
doaj   +2 more sources

Investigating Serum and Placental Levels of IGF-1 and IGF-1R in Preeclampsia Patients and Their Clinical Implications [PDF]

International Journal of Women's Health
Junyou Su,1,* Xiaoting Huang,1,* Shengping Meng,2 Sumei Wang2 1Department of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, People’s Republic of China; 2Department of Obstetrics, The First ...
Su J, Huang X, Meng S, Wang S
doaj   +2 more sources

IGF-1R targeting in cancer – does sub-cellular localization matter? [PDF]

Journal of Experimental & Clinical Cancer Research, 2023
The insulin-like growth factor receptor (IGF-1R) was among the most intensively pursued kinase targets in oncology. However, even after a slew of small-molecule and antibody therapeutics reached clinical trials for a range of solid tumors, the initial ...
Upendra K. Soni, Liam Jenny, Rashmi S. Hegde   +2 more
doaj   +2 more sources

IGF-1R promotes pain-like behavior in rats with myofascial pain syndrome via the PI3K/AKT pathway [PDF]

Scientific Reports
Myofascial pain syndrome (MPS) is a common chronic pain condition characterized primarily by the presence of myofascial trigger points (MTrPs). While the insulin-like growth factor-1 receptor (IGF-1R) is known to be upregulated in injured muscles and ...
Lingwei Zhou, Miao Pei, Tian Qi, Yu Liu, Xiaoyue Li, Xuan Li, Qinghe Chen, Feihong Jin, Shaozhong Yang, Feng Qi   +9 more
doaj   +2 more sources

Linsitinib inhibits proliferation and induces apoptosis of both IGF-1R and TSH-R expressing cells [PDF]

Frontiers in Immunology
BackgroundThe insulin-like growth factor 1 receptor (IGF-1R) and the thyrotropin receptor (TSH-R) are expressed on orbital cells and thyrocytes. These receptors are targeted in autoimmune-induced thyroid eye disease (TED). Effective therapeutic treatment
Maximilian Luffy, Anna-Lena Ganz, Stefanie Wagner, Jan Wolf, Julian Ropertz, Ryan Zeidan, Jeffrey D. Kent, Raymond S. Douglas, George J. Kahaly   +8 more
doaj   +2 more sources

Preclinical Evaluation of a New Format of ⁶⁸Ga- and ¹¹¹In-Labeled Affibody Molecule Z_IGF-1R:4551 for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT

Pharmaceutics, 2022
The Insulin-like growth factor-1 receptor (IGF-1R) is a molecular target for several monoclonal antibodies undergoing clinical evaluation as anticancer therapeutics. The non-invasive detection of IGF-1R expression in tumors might enable stratification of
Yongsheng Liu, Shengze Yu, Tianqi Xu, Vitalina Bodenko, Anna Orlova, Maryam Oroujeni, Sara S. Rinne, Vladimir Tolmachev, Anzhelika Vorobyeva, Torbjörn Gräslund   +9 more
doaj   +1 more source

Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets

Frontiers in Oncology, 2021
AimInsulin-like growth factor-1 receptor (IGF-1R) is one of the main members of the tyrosine protein kinase receptor family. This receptor binds insulin-like growth factor-1 (IGF-1) with a high affinity. IGF-1 is a member of a family of proteins involved
Yinqi Zhang, Yinqi Zhang, Chengqi Gao, Fei Cao, Fei Cao, Ying Wu, Ying Wu, Shuanggang Chen, Xue Han, Xue Han, Jingqin Mo, Zhiyu Qiu, Zhiyu Qiu, Weijun Fan, Weijun Fan, Penghui Zhou, Lujun Shen, Lujun Shen   +17 more
doaj   +1 more source