Drugging IGF-1R in cancer: New insights and emerging opportunities
Genes and Diseases, 2023 The insulin-like growth factor (IGF) axis plays important roles in cancer development and metastasis. The type 1 IGF receptor (IGF-1R) is a key member in the IGF axis and has long been recognized for its oncogenic role in multiple cancer lineages.
Lydia W T Cheung, Victor Chun Yin Mak
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IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells [PDF]
Cells, 2020 Triple-negative breast cancer (TNBC) is an aggressive breast tumor subtype that currently lacks targeted treatment options. The role played by the insulin-like growth factor-1 (IGF-1) and its cognate receptor IGF-1R in TNBC has been reported ...
Jorge Silvio Gutkind +2 more
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Pharmaceutics, 2022 The Insulin-like growth factor-1 receptor (IGF-1R) is a molecular target for several monoclonal antibodies undergoing clinical evaluation as anticancer therapeutics. The non-invasive detection of IGF-1R expression in tumors might enable stratification of
Yongsheng Liu +9 more
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Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets
Frontiers in Oncology, 2021 AimInsulin-like growth factor-1 receptor (IGF-1R) is one of the main members of the tyrosine protein kinase receptor family. This receptor binds insulin-like growth factor-1 (IGF-1) with a high affinity. IGF-1 is a member of a family of proteins involved
Yinqi Zhang +17 more
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Nuclear targeting of IGF-1 receptor in orbital fibroblasts from Graves' disease: apparent role of ADAM17. [PDF]
PLoS ONE, 2012 Insulin-like growth factor-1 receptor (IGF-1R) comprises two subunits, including a ligand binding domain on extra- cellular IGF-1Rα and a tyrosine phosphorylation site located on IGF-1Rβ.
Neil Hoa +6 more
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Knockout of insulin-like growth factor-1 receptor impairs distal lung morphogenesis. [PDF]
PLoS ONE, 2012 BACKGROUND: Insulin-like growth factors (IGF-I and -II) are pleiotropic regulators of somatic growth and development in vertebrate species. Endocrine and paracrine effects of both hormones are mediated by a common IGF type 1 receptor (IGF-1R).
Ralph Epaud +13 more
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Role of ubiquitination in IGF-1 receptor signaling and degradation. [PDF]
PLoS ONE, 2007 BACKGROUND: The insulin-like growth factor 1 receptor (IGF-1R) plays numerous crucial roles in cancer biology. The majority of knowledge on IGF-1R signaling is concerned with its role in the activation of the canonical phosphatidyl inositol-3 kinase ...
Bita Sehat +4 more
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Novel nuclear localization and potential function of insulin-like growth factor-1 receptor/insulin receptor hybrid in corneal epithelial cells. [PDF]
PLoS ONE, 2012 Type I insulin-like growth factor receptor (IGF-1R) and insulin receptor (INSR) are highly homologous molecules, which can heterodimerize to form an IGF-1R/INSR hybrid (Hybrid-R).
Yu-Chieh Wu +2 more
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Frontiers in Endocrinology, 2021 Ligand-induced activation of the IGF-1 receptor triggers plasma-membrane-derived signal transduction but also triggers receptor endocytosis, which was previously thought to limit signaling.
Leonie Rieger, Rosemary O’Connor
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Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma. [PDF]
PLoS ONE, 2014 The interaction between the tumor cells in classical Hodgkin lymphoma (cHL) and the microenvironment includes aberrant activity of receptor tyrosine kinases.
Zheng Liang +6 more
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