Results 21 to 30 of about 18,629 (186)
Targeting the IGF-1R: The Tale of the Tortoise and the Hare [PDF]
Frontiers in Endocrinology, 2015 The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development and maintenance of cancer. Since the first links between growth factor receptors and oncogenes were noted over three decades ago, targeting the IGF-1R has been of great interest.
Caitrin eCrudden +3 more
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Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma. [PDF]
PLoS ONE, 2014 The interaction between the tumor cells in classical Hodgkin lymphoma (cHL) and the microenvironment includes aberrant activity of receptor tyrosine kinases.
Zheng Liang +6 more
doaj +1 more source
Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection
Cell Death and Disease, 2022 Insulin-like growth factor I (IGF-1) is a neurotrophic factor and is the ligand for insulin-like growth factor 1 receptor (IGF-1R). Reduced expression of IGF-1 has been reported to cause deafness, mental retardation, postnatal growth failure, and ...
Ammaji Rajala +6 more
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The interplay between IGF-1R signaling and Hippo-YAP in breast cancer stem cells
Cell Communication and Signaling, 2023 Background Both IGF-1R/PI3K/AKT/mTOR and Hippo pathways are crucial for breast cancer stem cells (BCSCs). However, their interplay remains unclear. Methods Four triple negative breast cancer cell lines derived from CSC of two patient-derived xenografts ...
Yu-Tzu Chan +7 more
doaj +1 more source
Deficiency of insulin-like growth factor-1 receptor confers resistance to oxidative stress in C2C12 myoblasts. [PDF]
PLoS ONE, 2013 IGF-1 receptor (IGF-1R) signaling regulates cell growth, transformation and survival. Haploinsufficiency of the IGF-1R is reported to paradoxically confer resistance to oxidative stress in vivo and in cells cultured from Igf1r(+/-) mice.
Sachin Thakur, Neha Garg, Martin L Adamo
doaj +1 more source
Revisiting the IGF-1R as a breast cancer target [PDF]
npj Precision Oncology, 2017 AbstractThe type I insulin-like growth factor-1 receptor is a well-described target in breast cancer and multiple clinical trials examining insulin-like growth factor-1 receptor have been completed. Unfortunately, monoclonal antibodies and tyrosine kinase inhibitors targeting insulin-like growth factor-1 receptor failed in phase III breast clinical ...
Roudy Chiminch Ekyalongo, Douglas Yee
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Haematologica, 2010 Background Alterations in the PI3K/Akt pathway are found in a wide range of cancers and the development of PI3K inhibitors represents a promising approach to cancer therapy.
Nicolas Chapuis +12 more
doaj +1 more source
Respiratory Research, 2005 Background Cellular responses to aging and oxidative stress are regulated by type 1 insulin-like growth factor receptor (IGF-1R). Oxidant injury, which is implicated in the pathophysiology of a number of respiratory diseases, acutely upregulates IGF-1R ...
Flejou Jean-François +7 more
doaj +1 more source
Upregulation of IGF-1R expression during neoadjuvant therapy predicts poor outcome in breast cancer patients. [PDF]
PLoS ONE, 2015 The insulin-like growth factor 1 receptor (IGF-1R) may be involved in the development of resistance against conventional cancer treatment. The aim of this study was to assess whether IGF-1R expression of breast tumors changes during neoadjuvant therapy ...
Sandra Heskamp +9 more
doaj +1 more source
IGF-1R as an anti-cancer target--trials and tribulations [PDF]
Chinese Journal of Cancer, 2013 Type I insulin-like growth factor receptor (IGF-1R) has long been recognized for its role in tumorigenesis and growth, but only recently have the tools for targeting the IGF pathway become available. More than 10 IGF/IGF-1R inhibitors have entered clinical trials, and these belong to three main classes: (1) monoclonal antibodies against IGF-1R, (2 ...
Chen, Helen X., Sharon, Elad
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