Results 21 to 30 of about 124,813 (135)

Upregulation of IGF-1R expression during neoadjuvant therapy predicts poor outcome in breast cancer patients. [PDF]

PLoS ONE, 2015
The insulin-like growth factor 1 receptor (IGF-1R) may be involved in the development of resistance against conventional cancer treatment. The aim of this study was to assess whether IGF-1R expression of breast tumors changes during neoadjuvant therapy ...
Sandra Heskamp, Otto C Boerman, Janneke D M Molkenboer-Kuenen, Carla A Wauters, Luc J A Strobbe, Caroline M P W Mandigers, Peter Bult, Wim J G Oyen, Winette T A van der Graaf, Hanneke W M van Laarhoven   +9 more
doaj   +1 more source

PC1 regulates IGF-1-dependent IGF-1R activation.

, 2021
Cardiomyocytes were transfected with scrambled (Scr) or PC1 siRNA (siPC1), incubated for 24 h, and then stimulated with IGF-1 (10 nM) or vehicle for 5 min.
César Vásquez-Trincado (11292276), Camila López-Crisosto (2179768), Francisco Altamirano (494644), Natalia Torrealba (11292270), Zully Pedrozo (2967186), Carolina Fernández (5994746), Raúl Flores-Vergara (11292279), Sergio Lavandero (159188), María Paz Ocaranza (11292282), Valeria Garrido-Moreno (11292273), Mario Chiong (2179764)   +10 more
core   +1 more source

IGF-1R down regulates the sensitivity of hepatocellular carcinoma to sorafenib through the PI3K / akt and RAS / raf / ERK signaling pathways

BMC Cancer, 2023
Background Insulin-like growth factor-1 receptor (IGF-1R) promotes cell proliferation and migration and inhibitsapoptosis, all of which can contribute to the development of cancers.
Wenpeng Cai, Yongfang Ma, Li Song, Niandie Cao, Jiafeng Gao, Shuping Zhou, Xiaolong Tang   +6 more
doaj   +1 more source

High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507). [PDF]

PLoS ONE, 2009
The IGF receptor type 1 (IGF-1R) pathway is frequently deregulated in human tumors and has become a target of interest for anti-cancer therapy.We used a panel of 22 non-small cell lung cancer (NSCLC) cell lines to investigate predictive biomarkers of ...
Yixuan Gong, Evelyn Yao, Ronglai Shen, Aviva Goel, Maria Arcila, Julie Teruya-Feldstein, Maureen F Zakowski, Stanley Frankel, Martin Peifer, Roman K Thomas, Marc Ladanyi, William Pao   +11 more
doaj   +1 more source

IGF-1R and PTH1R RT-PCR Primers.

, 2016
IGF-1R and PTH1R RT-PCR Primers.
Guohong Du (3366695), Huijie Leng (494783), Chunli Song (2023402), Bao Hai (3366692), Hong Wang (13528), Wen Zhang (7555), Yingsheng Xu (3366698), Can Liu (205007)   +7 more
core   +1 more source

IGF-1R/mTOR Targeted Therapy for Ewing Sarcoma: A Meta-Analysis of Five IGF-1R-Related Trials Matched to Proteomic and Radiologic Predictive Biomarkers [PDF]

, 2020
Background : Ten to fourteen percent of Ewing sarcoma (ES) study participants treated nationwide with IGF-1 receptor (IGF-1R)-targeted antibodies achieved tumor regression.
Song, Juhee, Joseph A. Ludwig, Deeksha Vishwamitra, Eric R. Molina, Amin, Hesham M, Ludwig, Joseph A, Ravin Ratan, John A. Livingston, Razelle Kurzrock, Ajaykumar C. Morani, Subbiah, Vivek, Wang, Wei-Lien, Wei-Lien Wang, Naing, Aung, Bhawana George, Amin, Hesham M,; Morani, Ajaykumar C,; Daw, Najat C,; Lamhamedi-Cherradi, Salah-Eddine,; Subbiah, Vivek,; Menegaz, Brian A,; Vishwamitra, Deeksha,; Eskandari, Ghazaleh,; George, Bhawana,; Benjamin, Robert S,; Patel, Shreyaskumar,; Song, Juhee,; Lazar, Alexander J,; Wang, Wei-Lien,; Kurzrock, Razelle,; Pappo, Alberto,; Anderson, Peter M,; Schwartz, Gary K,; Araujo, Dejka,; Cuglievan, Branko,; Ratan, Ravin,; McCall, David,; Mohiuddin, Sana,; Livingston, John A,; Molina, Eric R,; Naing, Aung,; Ludwig, Joseph A,, Cuglievan, Branko, Salah-Eddine Lamhamedi-Cherradi, Branko Cuglievan, Ratan, Ravin, Gary K. Schwartz, George, Bhawana, Alexander J. Lazar, Juhee Song, Araujo, Dejka, Patel, Shreyaskumar, Pappo, Alberto, Sana Mohiuddin, Livingston, John A, Brian A. Menegaz, Aung Naing, Najat C. Daw, Benjamin, Robert S, Ghazaleh Eskandari, Lazar, Alexander J, Daw, Najat C, Kurzrock, Razelle, Molina, Eric R, Peter M. Anderson, Robert S. Benjamin, Anderson, Peter M, Morani, Ajaykumar C, Vishwamitra, Deeksha, Hesham M. Amin, McCall, David, Dejka Araujo, Menegaz, Brian A, Vivek Subbiah, Schwartz, Gary K, Shreyaskumar Patel, Mohiuddin, Sana, Lamhamedi-Cherradi, Salah-Eddine, David McCall, Eskandari, Ghazaleh, Alberto Pappo   +54 more
core   +1 more source

Subcellular localization of IGF-1R/IGF-1R and IGF-1R/INSR hybrid.

, 2012
(A) Presence of IGF-1R/INSR hybrid in the nucleus. Cytosolic (Cyto) and nuclear (Nuclear) fractions of hTCEpi cells were immunoprecipitated with anti-IGF-1Rβ (CST#3027) or anti-INSRβ (C-19) and then immunoblotted with the same antibodies.
Danielle M. Robertson (145361), Yu-Chieh Wu (145354), Meifang Zhu (145357)   +2 more
core   +1 more source

Fluorescent-Antibody Targeting of Insulin-Like Growth Factor-1 Receptor Visualizes Metastatic Human Colon Cancer in Orthotopic Mouse Models. [PDF]

PLoS ONE, 2016
Fluorescent-antibody targeting of metastatic cancer has been demonstrated by our laboratory to enable tumor visualization and effective fluorescence-guided surgery.
Jeong Youp Park, Takashi Murakami, Jin Young Lee, Yong Zhang, Robert M Hoffman, Michael Bouvet   +5 more
doaj   +1 more source

Insulin-Like Growth Factor-1 Receptor Targeted Fluorescent Imaging for Gallbladder Cancer in Orthotopic Mouse Models

Gut and Liver, 2022
Background/Aims: Gallbladder cancer is fatal, but fluorescent imaging technology can facilitate timely diagnosis and improve patient outcomes. Fluorophore-conjugated insulin-like growth factor-1 receptor (IGF-1R) targeted antibodies were used to ...
Jung Ha Choi, Jeong Youp Park
doaj   +1 more source

IGF-1R expression is mostly from CD34⁺ and CD33⁺cell population.

, 2016
Four PV patients with elevated IGF-1R were studied. Flow cytometry analysis was done to investigate which cell populations produce IGF-1R. Setting IGF-1R (MFI) of mononuclear cell population values as 100%, CD33-CD34- cells were found to be 58±14%; CD33 ...
Jen C. Wang (244439), Ching Wong (707603), Hemant Sindhu (707600), Vladimir Gotlieb (3331515), Maryna Yarotska (3331521), Hui Chen (28597), Madhumati Kalavar (3331518), Andrei Bandarchuk (3331509), Stacey Baptiste (3331524), Guanfang Shi (3331512)   +9 more
core   +1 more source