Results 11 to 20 of about 18,629 (186)
Molecular Imaging of IGF-1R in Cancer [PDF]
Molecular Imaging, 2017 The important role of insulin-like growth factor 1 receptor (IGF-1R) in malignant tumors has been well established. Increased IGF-1R activity promotes cancer cell proliferation, migration, and invasion and is associated with tumor metastasis, treatment ...
Yingying Sun PhD +2 more
doaj +3 more sources
Lactoferrin Induces Osteoblast Growth through IGF-1R [PDF]
International Journal of Endocrinology, 2015 Objectives. To investigate the role of the IGF-1R by which lactoferrin induces osteoblast growth. Methods. Osteoblast received 5 d lactoferrin intervention at a concentration of 0.1, 1, 10, 100, and 1000 μg/mL, and the IGF-1 and IGF-1R were detected ...
Jian-Ming Hou +6 more
doaj +3 more sources
Nuclear targeting of IGF-1 receptor in orbital fibroblasts from Graves' disease: apparent role of ADAM17. [PDF]
PLoS ONE, 2012 Insulin-like growth factor-1 receptor (IGF-1R) comprises two subunits, including a ligand binding domain on extra- cellular IGF-1Rα and a tyrosine phosphorylation site located on IGF-1Rβ.
Neil Hoa +6 more
doaj +1 more source
Allosteric IGF-1R Inhibitors [PDF]
ACS Medicinal Chemistry Letters, 2010 Targeting allosteric protein sites is a promising approach to interfere selectively with cellular signaling cascades. We have discovered a novel class of allosteric insulin-like growth factor-I receptor (IGF-1R) inhibitors. 3-Cyano-1H-indole-7-carboxylic acid {1-[4-(5-cyano-1H-indol-3-yl)butyl]piperidin-4-yl}amide (10) was found with nanomolar ...
Heinrich, Timo +4 more
openaire +3 more sources
Knockout of insulin-like growth factor-1 receptor impairs distal lung morphogenesis. [PDF]
PLoS ONE, 2012 BACKGROUND: Insulin-like growth factors (IGF-I and -II) are pleiotropic regulators of somatic growth and development in vertebrate species. Endocrine and paracrine effects of both hormones are mediated by a common IGF type 1 receptor (IGF-1R).
Ralph Epaud +13 more
doaj +1 more source
Role of ubiquitination in IGF-1 receptor signaling and degradation. [PDF]
PLoS ONE, 2007 BACKGROUND: The insulin-like growth factor 1 receptor (IGF-1R) plays numerous crucial roles in cancer biology. The majority of knowledge on IGF-1R signaling is concerned with its role in the activation of the canonical phosphatidyl inositol-3 kinase ...
Bita Sehat +4 more
doaj +1 more source
CXCL14 Maintains hESC Self-Renewal through Binding to IGF-1R and Activation of the IGF-1R Pathway [PDF]
Cells, 2020 Human embryonic stem cells (hESCs) have important roles in regenerative medicine, but only a few studies have investigated the cytokines secreted by hESCs. We screened and identified chemokine (C-X-C motif) ligand 14 (CXCL14), which plays crucial roles in hESC renewal.
Chih-Lun Cheng +11 more
openaire +3 more sources
The Role of IGF-1R in Pediatric Malignancies [PDF]
The Oncologist, 2009 Learning Objectives Evaluate the components that make up the insulin-like growth factor family. Differentiate between different strategies to modulate IGF-1R. Determine when to utilize the rationale for therapeutic targeting of IGF-1R in childhood malignancies.
Su Young, Kim +3 more
openaire +2 more sources
Novel nuclear localization and potential function of insulin-like growth factor-1 receptor/insulin receptor hybrid in corneal epithelial cells. [PDF]
PLoS ONE, 2012 Type I insulin-like growth factor receptor (IGF-1R) and insulin receptor (INSR) are highly homologous molecules, which can heterodimerize to form an IGF-1R/INSR hybrid (Hybrid-R).
Yu-Chieh Wu +2 more
doaj +1 more source
Frontiers in Endocrinology, 2021 Ligand-induced activation of the IGF-1 receptor triggers plasma-membrane-derived signal transduction but also triggers receptor endocytosis, which was previously thought to limit signaling.
Leonie Rieger, Rosemary O’Connor
doaj +1 more source