Results 11 to 20 of about 124,813 (135)

Lactoferrin Induces Osteoblast Growth through IGF-1R [PDF]

International Journal of Endocrinology, 2015
Objectives. To investigate the role of the IGF-1R by which lactoferrin induces osteoblast growth. Methods. Osteoblast received 5 d lactoferrin intervention at a concentration of 0.1, 1, 10, 100, and 1000 μg/mL, and the IGF-1 and IGF-1R were detected ...
Jian-Ming Hou, En-Yu Chen, Fan Lin, Qing-Ming Lin, Ying Xue, Xu-Hua Lan, Man Wu   +6 more
doaj   +2 more sources

IGF-1R Inhibition Activates a YES/SFK Bypass Resistance Pathway: Rational Basis for Co-Targeting IGF-1R and Yes/SFK Kinase in Rhabdomyosarcoma

Neoplasia: An International Journal for Oncology Research, 2015
The insulin-like growth factor 1 receptor (IGF-1R) has surfaced as a significant target in multiple solid cancers due to its fundamental roles in pro-survival and anti-apoptotic signaling.
Xiaolin Wan, Choh Yeung, Christine Heske, Arnulfo Mendoza, Lee J. Helman   +4 more
doaj   +2 more sources

Molecular Imaging of IGF-1R in Cancer

Molecular Imaging, 2017
The important role of insulin-like growth factor 1 receptor (IGF-1R) in malignant tumors has been well established. Increased IGF-1R activity promotes cancer cell proliferation, migration, and invasion and is associated with tumor metastasis, treatment ...
Yingying Sun PhD, Xilin Sun PhD, Baozhong Shen MD, PhD   +2 more
doaj   +2 more sources

The interplay between IGF-1R signaling and Hippo-YAP in breast cancer stem cells [PDF]

Cell Communication and Signaling, 2023
Background Both IGF-1R/PI3K/AKT/mTOR and Hippo pathways are crucial for breast cancer stem cells (BCSCs). However, their interplay remains unclear. Methods Four triple negative breast cancer cell lines derived from CSC of two patient-derived xenografts ...
Yu-Tzu Chan, Ruey-Jen Lin, Ya-Hui Wang, Tsai-Hsien Hung, Yenlin Huang, John Yu, Jyh-Cherng Yu, Alice L. Yu   +7 more
doaj   +2 more sources

R1507, an anti-insulin-like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axis. [PDF]

PLoS ONE, 2011
A subset of patients with Ewing's sarcoma responds to anti-insulin-like growth factor-1 receptor (IGF-1R) antibodies. Mechanisms of sensitivity and resistance are unknown. We investigated whether an anti-IGF-1R antibody acts via a pathway that could also
Helen J Huang, Laura S Angelo, Jordi Rodon, Michael Sun, Klaus-Peter Kuenkele, Henrique A Parsons, Jonathan C Trent, Razelle Kurzrock   +7 more
doaj   +3 more sources

Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection

Cell Death and Disease, 2022
Insulin-like growth factor I (IGF-1) is a neurotrophic factor and is the ligand for insulin-like growth factor 1 receptor (IGF-1R). Reduced expression of IGF-1 has been reported to cause deafness, mental retardation, postnatal growth failure, and ...
Ammaji Rajala, Kenneth Teel, Mohd A. Bhat, Albert Batushansky, Timothy M. Griffin, Lindsey Purcell, Raju V. S. Rajala   +6 more
doaj   +1 more source

Deficiency of insulin-like growth factor-1 receptor confers resistance to oxidative stress in C2C12 myoblasts. [PDF]

PLoS ONE, 2013
IGF-1 receptor (IGF-1R) signaling regulates cell growth, transformation and survival. Haploinsufficiency of the IGF-1R is reported to paradoxically confer resistance to oxidative stress in vivo and in cells cultured from Igf1r(+/-) mice.
Sachin Thakur, Neha Garg, Martin L Adamo
doaj   +1 more source

Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody

Haematologica, 2010
Background Alterations in the PI3K/Akt pathway are found in a wide range of cancers and the development of PI3K inhibitors represents a promising approach to cancer therapy.
Nicolas Chapuis, Jérôme Tamburini, Pascale Cornillet-Lefebvre, Lucile Gillot, Valérie Bardet, Lise Willems, Sophie Park, Alexa S Green, Norbert Ifrah, François Dreyfus, Patrick Mayeux, Catherine Lacombe, Didier Bouscary   +12 more
doaj   +1 more source

Deficiency in type 1 insulin-like growth factor receptor in mice protects against oxygen-induced lung injury

Respiratory Research, 2005
Background Cellular responses to aging and oxidative stress are regulated by type 1 insulin-like growth factor receptor (IGF-1R). Oxidant injury, which is implicated in the pathophysiology of a number of respiratory diseases, acutely upregulates IGF-1R ...
Flejou Jean-François, Bonora Monique, Holzenberger Martin, Epaud Ralph, Ahamed Karmene, Puard Julien, Clement Annick, Henrion-Caude Alexandra   +7 more
doaj   +1 more source

Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment

Breast Cancer Research, 2018
Background Early analyses of human breast cancer identified high expression of the insulin-like growth factor type 1 receptor (IGF-1R) correlated with hormone receptor positive breast cancer and associated with a favorable prognosis, whereas low ...
Alison E. Obr, Sushil Kumar, Yun-Juan Chang, Joseph J. Bulatowicz, Betsy J. Barnes, Raymond B. Birge, Deborah A. Lazzarino, Emily Gallagher, Derek LeRoith, Teresa L. Wood   +9 more
doaj   +1 more source